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Biomedical subjects

A Limoge

Publications and source records attributed to A Limoge.

35 records · Page 2Linked to original sources
PubMed1982

Transcutaneous cranial electrical stimulation increases the potency of nitrous oxide in humans.

The potency, amnesic, and postanesthetic analgesic effects of transcutaneous cranial electrical stimulation (TCES) were evaluated during N2O anesthesia in 120 unpremedicated patients, prior to urologic or general surgical operations. The patients were divided into six groups of 20 each with respect to what concentration of N2O in oxygen they were allowed to breathe (75, 62.5, and 50%), and whether they were or were not stimulated with TCES. Recordings of heart and respiratory rates, systolic arterial blood pressure, and minute ventilation were made prior to and after 20 min of N2O, and one minute later following application of a Kocker clamp to the upper inner thigh for one minute. The presence or absence of movement during the painful stimulus, memory of the painful stimulus, and postanesthetic pain at the clamp site (20 min after anesthesia) were also evaluated. Patients who received TCES had significantly lower incidences of movement, memory of the painful stimulus, and postanesthetic pain at the stimulation site at each N2O concentration than patients not getting TCES. TCES did not alter circulatory and respiratory dynamics prior to painful stimulation and prevented an increase in arterial blood pressure during painful stimulation in patients receiving 50% N2O. These data indicate that TCES significantly increases the analgesic potency of N2O and probably also the depth of anesthesia.

Analgesia↗
PubMed1982

Transcutaneous cranial electrical stimulation decreases narcotic requirements during neurolept anesthesia and operation in man.

The influence of transcutaneous cranial electrical stimulation (TCES) on fentanyl requirements was evaluated in 50 patients undergoing urologic operations with pure neuroleptanesthesia (droperidol, diazepam, fentanyl, and air oxygen) with (group I) or without (group II) simultaneous TCES. All patients had silver electrodes (three) applied between the eyebrows and behind each mastoid process and attached to a 167-kHz current generator. Current was delivered only to group I. The wave form was a complex nonsinusoidal, nonsquare wave pattern which was applied intermittently in a 3-msec-on 10-msec-off sequence. All patients had anesthesia induced with droperidol (0.20 mg/kg IV), diazepam (0.2 mg/kg IV), and pancuronium (0.08 mg/kg IV), and, after tracheal intubation, had anesthesia maintained with fentanyl in 100-microgram intravenous increments every 3 minutes whenever and as long as systolic arterial blood pressure and/or heart rate were greater than 20% of control (preanesthetic induction) values. Fentanyl requirements averaged 6.1 +/- 0.5 and 7.9 +/- 0.4 microgram/kg/min for a mean total dosage of 9.0 +/- 0.9 and 12.5 +/- 0.8 microgram/kg for the entire operation in groups I and II, respectively. These differences between groups were statistically significant (p less than 0.05). The data demonstrate that TCES augments the analgesic effects of fentanyl and thus reduces fentanyl requirements during urologic operations with neuroleptanesthesia.

Aged↗
PubMedDate not supplied

Use of the jaw opening reflex for assessing the effects of local anaesthetics in freely moving rats.

INTRODUCTION: In order to characterize a nonbehavioral model for assessing local anaesthetic (LA) activity, the effects of different LA agents (articaine, bupivacaine, procaine, and tetracaine) were measured in the conscious rat using the jaw-opening reflex (JOR). METHODS: One hundred sixty rats were chronically implanted with stimulating electrodes in the dental pulp of the low incisor. While animals were conscious and unrestrained, the JOR threshold was measured electrophysiologically via electrodes wrapped around the digastric muscle. Each LA was administered in the infratemporal area. The increase of the JOR threshold was assessed during a 3-h period following injection. RESULTS: Statistical analysis of the data showed a dose-dependent response to the four drugs tested. When the highest dose of each drug (articaine and procaine: 24 mg kg(-1), bupivacaine: 6 mg kg(-1), tetracaine: 3 mg kg(-1)) was administered (i) an immediate effect was observed for tetracaine and bupivacaine, whereas a 5-min delay was needed for articaine and procaine to act on the JOR threshold and (ii) an increase (>60%) of the JOR threshold was observed. The effects lasted 90 min for articaine, 45 min for procaine and bupivacaine, and 15 min for tetracaine before a return to baseline values. DISCUSSION: The rat JOR response combined with infratemporal injection of test drugs can be used for the pharmacological evaluation of LAs.

Anesthetics, Local↗
PubMedDate not supplied

[Electropuncture].

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Acupuncture Therapy↗