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Biomedical subjects

A Linssen

Publications and source records attributed to A Linssen.

22 records · Page 2Linked to original sources
PubMed1983

Possible ankylosing spondylitis in acute anterior uveitis.

HLA-B27 typing of 103 acute anterior uveitis (AAU) patients showed that 49 (48%) were positive for this antigen. Of these HLA-B27 positive AAU patients, 27 (55%) had ankylosing spondylitis (AS) according to the New York criteria. The 22 HLA-B27 positive AAU patients without AS, however, also showed symptoms and signs of AS. Seventeen (77%) of these 22 HLA-B27 positive AS negative AAU patients fulfilled a set of criteria for classification as possible AS. In the group of 54 HLA-B27 negative AAU patients, only two patients (4%) had AS. Of the remaining 52 patients only seven (13%) had possible AS. Of the 21 patients having posterior uveitis (PU) none was HLA-B27 positive nor met the criteria for AS or possible AS. These findings indicate a strong relationship between AAU, AS or possible AS and HLA-B27 and suggest that HLA-B27 typing in AAU patients is important for early diagnosis of AS.

Acute Disease↗
PubMed1983

Acute anterior uveitis (AAU) and HLA-B27.

A group of 30 consecutive HLA-B27 positive acute anterior uveitis (AAU) patients was compared to 30 consecutive HLA-B27 negative AAU patients. The B27 positive group was characterized by male preponderance, earlier age of onset, unilateral uveitis and favourable outcome with therapy. It is concluded that HLA-B27 typing is a useful diagnostic discriminant in AAU.

Acute Disease↗
PubMed1982

Fulminant onset of Crohn's disease of the colon (CDC). An observation of six cases.

Six female patients are described with a fulminant onset of Crohn's's disease involving the whole of the colon. The initial picture resembled that of an acute infectious diarrhea, but rapid clinical deterioration with pronounced weight loss, major anal complications, toxic megacolon, and erythema nodosum necessitated reappraisal of the diagnosis. Extensive endoscopy and multiple biopsies confirmed the diagnosis of pancolitis in all patients. Only one patient needed resection. Recognition of such fulminant onset as a distinct clinical modality in Crohn disease of the colon and starting treatment immediately upon diagnosis is probably important in preventing the development of a critical clinical situation.

Adult↗