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Biomedical subjects

A Lopez-S

Publications and source records attributed to A Lopez-S.

9 recordsLinked to original sources

Nutrition and cancer: a curriculum and short student research experiences.

In 1988, Louisiana State University Health Sciences Center (LSUHSC) received an NCI/NIH R25 grant to strengthen nutrition-cancer education in the medical school and to provide short cancer-related research experiences for students. Support for the nutrition-cancer curriculum component of the grant was limited to the first five years, while renewal of the research component was possible on a competitive basis. After the initial five-year award ended, the administration of LSUHSC assumed the support of the nutrition-cancer curriculum. This curriculum, modified over time, continues to be taught in each year of medical school and culminates with a required clinical nutrition course in the fourth year. The teaching of nutrition continues to be very successful and is well received by students and faculty. The research component, renewed twice, has achieved its goals over the same period. As a consequence of the initial award and the commitment of the administration, nutrition education at LSUHSC remains strong and is well established.

Curriculum↗

Priorities for nutrition content in a medical school curriculum: a national consensus of medical educators.

The ASCN Committee on Medical/Dental School and Residency Nutrition Education conducted a series of activities to establish guidelines for nutrition core content in a medical school curriculum. These activities included mail surveys of medical-nutrition educators and a representative group of medical school curriculum administrators and a national consensus workshop of nutrition educators. Results indicated close agreement between the nutrition educators and curriculum administrators (r = 0.89, p less than 0.0001) on the importance ratings of 41 nutrition topics and on the number of hours of nutrition course work that medical schools should provide (44 vs 37 h, respectively, p = 0.14). There was consensus among the nutrition educators that 26 topics should be given priority ratings as essential for inclusion in medical course work. Further prioritization of these topics resulted in a listing of core content topics and subtopics to serve as a guide to administrators and educators for planning nutrition course work in a medical school curriculum.

Curriculum↗

Diet and exercise in middle-aged men.

Effects of an anaerobic exercise program on serum lipids and lipoproteins in sedentary male subjects were studied for 12 weeks. No dietary changes were made, and individuals were encouraged to maintain their body weight. Increase in lean body weight, decrease in percent body fat, and unchanged total body weight occurred in subjects participating in the resistive weight training program, while the men's serum cholesterol and low-density lipoprotein-cholesterol decreased and their high-density lipoprotein-cholesterol increased. Lipid profile improvements were attributed to exercise.

Adult↗

Total serum cholesterol and urinary dehydroepiandrosterone in humans.

The relationship between urinary excretion of dehydroepiandrosterone (DHEA) and total serum cholesterol was evaluated in an epidemiological study of coronary risk factors. The results of this study show statistically significant negative correlation (r = -0.238; P -0.014) between the urinary excretion of DHEA (mg/g creatinine) and total serum cholesterol. Total serum cholesterol (r = 0.278) and to a lesser extent. DHEA (R = 0.021) were found to be correlated with age. However, it was determined that the correlation between serum cholesterol and urinary DHEA was not attributable to the effect of age, since the partial correlation coefficient between serum cholesterol and urinary DHEA adjusted for age (r = 0.240) was found to be statistically significant (P less than 0.05). Negative but non-significant correlations were also found between urinary excretion of DHEA and many of the accepted risk factors for coronary heart disease.

Adolescent↗

Evaluation of an automated procedure for primary screening of hyperlipoproteinemias.

An automated procedure for the determination of beta-plus-pre-beta-lipoprotein cholesterol is described and evaluated for mass screening of hyperlipoproteinemias. It is shown that this method fulfills the requirements for an ideal method for primary screening: it can be used in non-fasting samples, is capable of detecting hyperlipoproteinemias characterized by both cholesterol and/or triglyceride abnormalities, is fast, accurate and extremely inexpensive. Evidence is shown that the method is extremely useful for primary screening and, when tested in a coronary screening detection program, gave only 4% false positive and 3.4% false negative results.

Autoanalysis↗

Effect of lipids on glucagon secretion in man.

Animal experiments have suggested a FFA control mechanism for glucagon secretion. In man, the potent effect of FFA on HGH secretion and the similarity of the secretory control mechanisms for HGH and IRG also support a role of FFA in IRG secretion. Our studies in man in which plasma FFA were elevated by either an oral lipid emulsion (Lipomul) or an intravenous lipid suspension (Intralipid)suggest only a minor role of lipids in control of IRG secretion. Plasma FFA and triglyceride elevations did not suppress arginine- or hypoglycemia-induced plasma IRG elevations, but an inhibitory effect of Intralipid on basal plasma IRG concentrations was observed. Although nicotinic acid administration, which caused a depression in plasma FFA, did elevate plasma IRG, the IRG elevation was considered more likely a consequence of stress induced by the drug. The failure of lipids to inhibit IRG secretion at FFA concentrations inhibiting HGH secretion indicates a dissociation in the secretory control mechanisms of the two hormones.

Administration, Oral↗