Biomedical subjects

A Lovisato

Publications and source records attributed to A Lovisato.

3 recordsLinked to original sources

PubMed1997

Postoperative cellular reaction on various intraocular lens materials.

PURPOSE: The presence of cellular deposits on the surface of intraocular lenses (IOLs) is a manifestation of: (1) the breakdown of the blood-aqueous barrier produced by surgery; and (2) foreign body reaction induced by lens implantation. The purpose of this study was to assess the presence of cellular deposits on the surfaces of various IOL materials. METHODS: Fifty patients scheduled for cataract surgery were randomized into five groups of ten patients each and received IOLs of the following materials: conventional polymethylmethacrylate (PMMA), surface-passivated PMMA, heparin-surface modified PMMA, poly-hydroxyethylmethacrylate (HEMA) hydrogel and silicone. Patients were examined at 7 days, 30 days, 90 days, and 180 days after surgery. All eyes were observed first via slit-lamp and then using a contact specular microscope for photographic documentation. RESULTS: Small, spindle-shaped cells were observed on all IOLs in the early postoperative period. Epithelioid cells appeared approximately 30 days after surgery on all PMMA IOLs, but most particularly on conventional PMMA IOLs. No cells were observed on poly-HEMA and silicone IOLs. CONCLUSIONS: The decreased number of epithelioid cells discovered in the early postoperative period may indicate a reduction in the inflammatory process induced by surgery. The permanence of epithelioid cells on IOL surfaces may be a sign of foreign body reaction. The results of this study indicated that poly-HEMA and silicone IOLs showed fewer cellular deposits than PMMA IOLs, suggesting that they may be better tolerated than PMMA IOLs.

Biofilms↗

PubMed1997

Corneal endothelial function after extracapsular cataract extraction and phacoemulsification.

PURPOSE: To compare the morphology and function of the corneal endothelium in the early postoperative period after extracapsular cataract extraction (ECCE) and phacoemulsification. SETTING: University Eye Clinic of Trieste, Italy. METHODS: In this prospective, randomized study of patients scheduled for cataract surgery, 40 patients were divided into two groups of 20 patients each. Group 1 had ECCE and Group 2, phacoemulsification; both had capsular bag intraocular lens (IOL) implantation. Preoperatively and 7 and 30 days postoperatively, a complete ophthalmological examination, endothelial specular microscopy, ultrasonic pachymetry, and anterior segment fluorophotometry were done. Visual acuity, endothelial cell density, cell size variation coefficient, corneal thickness, endothelial permeability coefficient, and endothelial pump function were studied. RESULTS: Visual acuity was better 7 days after phacoemulsification than after ECCE, but no differences were observed after 30 days. No significant differences in postoperative loss of endothelial cells were found between the two groups. Coefficient of variation in size, corneal thickness, and endothelial permeability significantly increased in both groups 7 days postoperatively, but only in the ECCE group 30 days postoperatively; the differences between the two groups were statistically significant. Endothelial pump function significantly increased after 7 days in only the phacoemulsification group. CONCLUSIONS: Functional endothelial failure occurred in the early period after ECCE. Phacoemulsification seemed to minimize postoperative functional damage to the endothelium.

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PubMed1997

Corneal endothelial protection by different viscoelastics during phacoemulsification.

PURPOSE: To evaluate corneal endothelium morphology and function after phacoemulsification using different viscoelastics. SETTING: Eye Clinic, University of Trieste, Italy. METHODS: This prospective, randomized study included results of preoperative and postoperative (7, 30, and 90 days) examinations of 66 patients scheduled for phacoemulsification without ocular pathology; 8 patients were excluded. Patients were randomly assigned to one of four groups based on type of viscoelastic used: 1% sodium hyaluronate (Healon); 1.4% sodium hyaluronate (Healon GV); 4% sodium chondroitin sulfate-3% sodium hyaluronate (Viscoat); 2% hydroxypropyl methylcellulose (Hymecel). Mean cell density and cell size variation coefficient were determined by specular microscopy; central corneal thickness, by ultrasonic pachymetry; and endothelial permeability coefficient and active pump function, by anterior segment fluorophotometry. RESULTS: There were no significant differences in postoperative mean cell loss among the groups. The cell size variation coefficient was altered in all groups 7 days after surgery and was still impaired at 30 days in the Hymecel group. A significant increase in mean corneal thickness, endothelial permeability, and active pump function occurred in the Healon and Hymecel groups 7 days after surgery. These parameters were still altered 30 days after surgery in the Hymecel group. Endothelial functional alterations did not occur in the Healon GV or Viscoat group. CONCLUSION: Viscoat and Healon GV are effective in minimizing functional damage of endothelial structure in the early medium-term postoperative period.

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