The effect of cathepsin inhibitor on rat embryos grown in vitro.
Explore the source record for details and available documents.
Amino Acids↗
Biomedical subjects
A Lowy
Publications and source records attributed to A Lowy.
Genetically restricted antigen presentation for immunological tolerance and suppression.
The activation of some subsets of T cells requires the recognition of antigen in association with self Ia determinants. It is not clear, however, whether this is also necessary for the induction of unresponsiveness and the active suppression of hapten-specific T cells. We have studied the regulation of the delayed-type hypersensitivity (DTH) response in mice. Subcutaneous (s.c.) injection of haptenated syngeneic cells primarily activates T helper cells, while intravenous (i.v.) injection results in unresponsiveness and the activation of T suppressor cells. Presentation of antigen by an I-A-positive antigen-presenting cell (APC) seems to be critical for T helper cell activation. We now show that the activation of first-order T suppressor cells requires the presentation of hapten on an I-J-positive APC. However, i.v. injection of I-J-depleted haptenated cells also results in hepten-specific unresponsiveness. This non-transferable T-cell tolerance requires the presence of an I-A-positive APC and is genetically restricted. These results suggest that distinct modes of antigen presentation and administration are required for immunity, suppression and non-transferable tolerance.
Animals↗
Sinus tarsi syndrome: a postoperative analysis.
A more thorough understanding of sinus tarsi syndrome has been attempted by a postoperative survey of patients who have undergone sinus tarsi decompression. An analysis of 22 cases of sinus tarsi syndrome that were operated on between 1980 and 1984 at Kern Hospital was made. In each case a surgical procedure similar to that described by O'Connor and Brown was utilized. It was concluded that sinus tarsi syndrome is a distinct clinical entity--a sequela of ankle injury that is easily diagnosed. It responds well to surgical intervention and offers little chance of postoperative complication.
Adolescent↗