Biomedical subjects

A Lundell

Publications and source records attributed to A Lundell.

22 records · Page 2Linked to original sources

PubMed1990

A stable prostacyclin analogue (iloprost) in the treatment of ischaemic ulcers of the lower limb. A Scandinavian-Polish placebo controlled, randomised multicenter study.

The clinical efficacy of the prostacyclin analogue iloprost was studied during a 2 week treatment and 6 month follow-up period in 103 patients with ischaemic ulcers who were randomised to receive active treatment or placebo. Responders were defined as those patients who achieved healing of at least one third of the ulcer area during the study period. The overall responder rate was 41.3%, compared with 25% for the control group (P = 0.086). Side effects including flushing and headache, were common. The study population had a mortality of 23% during the 6 month period, the amputation rate was 43.5% for iloprost and 50% for placebo treated patients. In this severely diseased population of patients a treatment period limited to 2 weeks did not sufficiently improve ulcer healing.

Adult↗

PubMed1987

Binding to galactose alpha 1----4galactose beta-containing receptors as potential diagnostic tool in urinary tract infection.

The diagnosis of urinary tract infection is based largely on quantitative urine cultures. The usefulness of qualitative information about the virulence of the infecting bacteria remains undefined. Ability to attach to human uroepithelial cells is one characteristic of the pyelonephritogenic clones, as well as a virulence factor per se. The identification of host cell receptors for attaching bacteria has permitted the construction of agglutination tests for simple detection of bacterial binding properties. In the present study, the reactivity with Gal alpha 1----4Gal beta-latex [galactose alpha (1----4)galactose beta-latex] and globotetraosylceramide-latex was analyzed for strains from patients with acute pyelonephritis (n = 135), acute cystitis (n = 121), and asymptomatic bacteriuria (n = 119) and from the fecal flora of healthy children (n = 120) and compared with agglutination of human blood group P1 and p, as well as guinea pig, erythrocytes. The reactivity by bioassay and the receptor-specific assays were significantly correlated. The frequency of positive reactions among the pyelonephritis isolates was 78.5% with the globotetraosylceramide-latex reagent, compared with 41% for the cystitis isolates, 25% for the asymptomatic bacteriuria isolates, and 13% for the fecal isolates. The combination of bioassays and receptor-specific assays increased the resolution of adhesins. Thus, adhesins reacting with human p erythrocytes frequently were coexpressed with Gal alpha 1----4Gal beta-specific adhesins. The receptor-specific assays provide a refined reagent to resolve bacterial binding specificities, as well as a potential tool for clinical diagnosis.

Adhesins, Escherichia coli↗

PubMed1983

An open dose finding study of melperone in treatment of agitation and irritability associated with dementia.

Seventeen older patients with a diagnosis of Organic Brain Syndrome were placed on a four-week trial of melperone for treatment of behavioural disturbances associated with dementia. Efficacy evaluation of the drug revealed improved ratings of the patients in the areas of agitation/irritability, anxiety, unsociability, and mental alertness. Thirteen of the fourteen patients who completed the trial were rated generally as showing at least minimal improvement while on the drug. There were no serious side effects noted, with drowsiness the most frequent finding. These favourable results are suggestive of the usefulness of this drug, and point to the need for double-blind, comparative studies.

Aged↗

PubMedDate not supplied

Patency of the plantar arch as a prognostic indicator in patients with critical leg ischaemia; a retrospective study.

OBJECTIVE: To find out if patency of the plantar arch on the preoperative angiogram was an accurate indicator of prognosis of vascular intervention, of leg salvage and of survival in patients with critical ischaemia of the leg. DESIGN: Retrospective study. SETTING: University Hospital. SUBJECTS: 302 patients who underwent femoral angiography for critical ischaemia of the leg in 1985-1986. INTERVENTIONS: Examination of aortofemoral angiograms and scoring of the radiological changes according to a suggested scoring system. MAIN OUTCOME MEASURES: Correlation of scores with outcome. RESULTS: Patients with patent plantar arches had a significantly higher cumulative patency after vascular intervention (logrank chi 2 4.2, p < 0.05), leg salvage (logrank chi 2 11.9, p < 0.01) and significantly longer survival (logrank chi 2 7.8 p < 0.01) than patients with partly or completely occluded plantar arches. CONCLUSION: It is important to see the plantar arch on the preoperative angiogram. The scoring system is valuable in predicting patency after vascular intervention, leg salvage and survival.

Adult↗