Biomedical subjects
Publications and source records attributed to A Lundström.
Pieces of plantar stratum corneum were incubated with trypsin. This resulted in cell dissociation. The only observable ultrastructural change caused by trypsin was a degradation of desmosomal plates between dissociating cells. This suggests that desmosomes are of primary importance in plantar stratum corneum cell adhesion.
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The purpose of this article is to test the hypothesis that the establishment of nasal respiration in children with severe nasopharyngeal obstruction can be eliminated as a factor in determining mandibular growth direction. The article describes the changes in mandibular growth direction (MGD) in a 5-year period after adenoidectomies and the establishment of nasal breathing in a population of Swedish children. Measurements of mandibular growth directions were obtained from serial cephalometric radiographs after adenoidectomies in 38 Swedish children aged 7 to 12 years with previous nasopharyngeal obstructions. These were compared with the growth directions in a control sample of 37 Swedish children with clear airways and matched for age and sex. The adenoidectomy sample initially showed significantly longer lower face heights, steeper mandibular plane angles, and more retrognathic mandibles than the matched controls. Analysis showed that during the 5 years after adenoidectomies, the girls had a more horizontal MGD (P less than 0.02) than did the female controls. A corresponding but not significant trend was found for the boys. The individual growth directions that were obtained following adenoidectomies were more variable than those found in the controls.
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The aim of the present study was to analyze the effect of systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease. 9 patients volunteered for the combined therapy. At a baseline examination they were randomly distributed into 2 groups, one given tetracycline therapy for 2 weeks and the other metronidazole therapy for 1 week. A mechanical plaque control program comprising oral hygiene training, professional cleaning of all teeth and subgingival debridement at diseased sites was carried out at the baseline examination and at all recall visits, i.e. once every month during the first 6 months and then after 9, 12, and 18 months. The results demonstrated clinically and microbiologically that a combination of an initial antimicrobial and a continuous systematic mechanical plaque control program may be a valuable therapeutic approach in a strictly selected group of refractory patients. Recurrent periodontal lesions which still displayed severe inflammation despite renewed conventional therapy showed a marked reduction in probing depths, bleeding and suppuration from the pockets, and further, a reduced presence of spirochetes and motile rods during the trial. The results indicate that the level and longevity of success is also related to whether or not self-performed oral hygiene measures are sufficiently carried out. No superior effect of the combined program could be observed in cooperating patients receiving tetracycline as compared with those given metronidazole.
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The aim of the study was, due to two recent reports about gingival and mucosal lesions, to survey the frequency of intraoral side effects in connection with sodium valproate treatment in epileptics. All patients on this drug treatment available at the University Hospital in Linköping, Sweden - in all 10 children, aged 8-14 - with absence seizures (simple petit mal), and treated for 1 to 4 yr, constituted a treatment group. Untreated age-matched, newly diagnosed epileptics constituted a comparison group. In each individual the oral hygiene state, gingival and periodontal condition, mucosal condition, caries prevalence, saliva secretion rate, salivary buffer capacity and lactobacillus count were estimated. The results revealed no divergences in the treated as compared with the untreated individuals which could be regarded as intraoral side effects deriving from the drug treatment.
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A new model for ranking of the combined mortality-effect of systolic and diastolic blood pressure in relation to age is described. The ranking allows continuous comparison of arbitrary blood pressures and making a percentile distribution of the risk according to the distribution of the population with respect to blood pressure and age. The model suggests new ways of attacking the problems of hypertension in man which are briefly introduced. It is suggested that systolic (Ps) and diastolic (Pd) blood pressure are converted to the biological effective blood pressure (Pe) by: Pe = 0.45Ps + 0.55Pd.
Oral conditions were studied in 48 children and adolescents who, during short or long periods, had been assigned to anti-epileptic drug treatment with carbamazepine or phenytoin. The individuals were diagnosed as suffering from partial seizures or generalized tonic-clonic seizures and were distributed between three test groups according to the drug selected for treatment; patients on active carbamazepine (I) or phenytoin (II) medication, and patients previously treated with phenytoin (III). Untreated, newly diagnosed epileptics served as controls. The results showed that individuals treated with carbamazepine for an average of 3 years displayed no intra-oral side-effects from the drug treatment. Compared with those on carbamazepine medication the subjects treated with phenytoin demonstrated a significantly greater number of gingival units with increased probing depths, lower saliva secretion rates and lower salivary buffer capacities. In all groups a majority of the individuals showed unsatisfactory plaque control. As a consequence of the results of the investigation it appears justified, from a dental point of view, to support carbamazepine as the first drug of choice for treatment of the types of seizures mentioned.
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