Biomedical subjects
Publications and source records attributed to A Lupovitch.
A rare and possibly unique benign polypoid tumour of the palatine tonsil is described. It contained the two basic tissue types of the tonsil--lymphoid and epithelial--in the characteristic close anatomical relationship of tonsillar tissue. The features of this rare lesion lend support to the hypothesis that benign tumours of the tonsil may be hamartomas of tonsil or branchiogenic remnants rather than true neoplasms.
A 65-yr-old man presented with upper abdominal pain and fever due to a primary abscess of the omentum. The finding of microscopic-size foreign particles within the abscess raised the possibility of antecedent clinically silent perforation of the bowel or appendix. Surgical resection and antibiotic therapy were curative.
We report a case of cholesteatoma of the renal pelvis with a 56-year followup. Quiescence of the disease with remission of symptoms, stabilization of the lesion and absence of further anatomical change was related temporally to treatment with vitamin A. The disease in our patient was idiopathic and no causative or predisposing factors were demonstrated.
Fine-needle aspiration biopsy (FNAB) was employed in the management of 66 patients with suspected pulmonary neoplasms. The most frequent indication for FNAB in this series occurred in 35 (53.0%) patients in whom the results of lesser procedures had been normal. Coexisting pulmonary disease, bilateral pulmonary lesions, distant metastases, and refusal to undergo surgical procedures accounted for the remaining patients. The results indicated a sensitivity (true-positive rate) of 95% and a specificity (true-negative rate) of 100%. Pneumothoraces followed aspiration biopsy in 8 patients (13.6% of the entire group), and a thoracostomy tube was required in 7 patients (10.6% of the entire group). The use of FNAB in patients suspected of harboring lung tumors furnished prompt and accurate results without serious complications. Increased experience by thoracic surgeons with this simple diagnostic tool is recommended.
In creating a computerized system to process its ever-increasing amounts of patient information, Holy Cross Hospital, Detroit, considered physicians' needs. It used three sets of observations to determine medical staff priorities: review of information flow in the diagnostic, patient care, and medical records departments; medical staff interviews; and experience with a physician-oriented computerized laboratory reporting system. These observations revealed mutual departmental needs; physicians' need for a clear, accurate summary of new patient data, with ready access via terminals; and the need for several report formats, including ward, summary, cumulative, and interpretative reports. Physicians input is essential to prioritize daily reports. A keyboard option that allows data processing staff to change formats easily is also important. All patient data must be computerized and the resulting computer reports have three basic parts: patient demographic data; the body, which contains basic information and observations; and the conclusion or summary. In developing reports, the staff must consider technological differences between departments and changing demands as physicians become familiar with the potential of computerized data.
We have investigated glycosylation of lens proteins in diabetic and non-diabetic senile cataract patients. Our study reveals that glycosylation of lens cortical proteins, but not of nuclear proteins, is significantly higher in diabetic patients with senile cataract. This finding serves to clarify the confusion over glycosylation of lens proteins as it relates to diabetes mellitus and further contributes to an understanding of glycosylation of lens tissues as a distinct posttranslational modification.
Glycosylation represents a nonenzymatic posttranslational modification of some proteins in vivo. We have investigated possible glycosylation, in vivo, of human lens capsule (basement membrane of lens epithelium) using a colorimetric method. Our study reveals, for the first time, in vivo glycosylation of human lens capsule. Furthermore, the glycosylation of the lens capsule in the diabetics (57.30 +/- 11.26 n moles/mg. protein) is found to be significantly greater than that in their nondiabetic counterparts (29.11 +/- 4.90 n moles/mg. protein) (p less than 0.0005). The present observation represents the first example of increased glycosylation of a basement membrane in the diabetic patients as compared to the nondiabetic controls.
Automation can be applied to the repetitive and mechanical handling, mixing, and dispensing of formaldehyde, the most common tissue fixative in routine clinical laboratory use. A closed automated system is described that aspirates 37% formaldehyde from large, commercial sized 490 pound drums at a remote location, and delivers 10% formalin in ready-to-use form at a special faucet in the histology laboratory without human intervention. In addition to economy from a decrease in personnel handling time and from purchasing formaldehyde in bulk, it decreases the exposure of laboratory personnel to formaldehyde fumes.
For cases of myocardial infarction, the laboratory must provide data to help clarify diagnosis, determine prognosis, follow the course of healing, and even quantitate the injury. An interpretive report of sequential enzyme studies performed on samples obtained during the first 48 hours after the admission of patients who had myocardial infarctions is described. The report is composed by using a modest data processing apparatus, incorporates comments based on the results of preprogrammed correlative studies, and calculates the extent of the injury in gram-equivalents of myocardium. Using this approach, analysts and clinicians should be able to design a biochemical profile of a myocardial infarct suitable for use in their own institution.
The reporting of gastric analysis data requires clearly formatted and documented analytic results, accurately calculated secretory rates, appropriate normal values based on age, sex and weight of the patient, and interpretive review of the data based on well-documented personal experience or comprehensive studies reported in the medical literature. We report here a technique using inexpensive and flexible data processing equipment suitable to most community hospital laboratories.
A manual and a computerized system that produce cumulative updated reports from the clinical microbiology laboratory are described. Each system gives the physician a report that is clearly formatted, cumulative, readily updated, and written in conversational terms with minimal abbreviations. The report formats and updating sequences are nearly identical, so that one system can easily replace or back up the other. The cost and complexity of the hardware and software for the computerized system are modest, so that these are suitable for the moderate-sized hospital laboratory processing fewer than 10,000 specimens per year. Also, the laboratory personnel in our community-based nonteaching hospital were able to develop, set up, and support these systems without external consultation or purchased services. Therefore, the improved quality of reporting based on these types of systems can now be available to all laboratories without regard to size or workload.
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Using a programmable calculator able to control an output printing device, the Laboratory can issue a comprehensive Schilling test report describing the test, calculating the resulting excretion, interpreting its significance, and cautioning against possible inaccuracies.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.