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Biomedical subjects

A M Alexander

Publications and source records attributed to A M Alexander.

14 recordsLinked to original sources
PubMed1985

Anti-rheumatic and analgesic drug usage and acute gastro-intestinal bleeding in elderly patients.

The records of 1878 general medical in-patients (aged 75 years and over) at Hereford have been examined for associations between the commonly used antirheumatic and analgesic drugs and acute gastro-intestinal bleeding. One third of 93 in-patients admitted because of acute bleeding had been taking ibuprofen, indomethacin or aspirin. The usage of these drugs was significantly greater than in the control population who comprised the remaining 1785 elderly medical in-patients. It is suggested that very elderly patients taking any of these three drugs form a vulnerable high risk group who are liable to develop acute gastro-intestinal bleeding.

Acute Disease↗
PubMed1979

Interaction of aminoglycoside antibiotics with phospholipid liposomes studies by microelectrophoresis.

Microelectrophoresis was found to be a rapid method for studying the interaction between aminoglycoside antibiotics and liposomes prepared from acid phospholipids. The ability to cause charge reversal of liposomes prepared from phosphatidyl inositol was ranked in the order neomycin greater than gentamicin greater than tobramycin greater than amikacin greater than kanamycin greater than ribostamycin greater than streptomycin greater than dihydrostreptomycin greater than Ca2+. Similar results were obtained with liposomes prepared from a mixture (8: 2) of phosphatidyl choline and phosphatidic acid, but no effect was detectable with neutral liposomes made from phosphatidyl choline only. The results support the view that the attraction between positively charged nitrogen groups on the antibiotics and the negatively charged groups of acidic phospholipids are predominantly responsible for the interaction. Extension of the studies to ionic strengths and calcium concentrations similar to those found in vivo showed a reduction, but not elimination, of the observed effects.

Aminoglycosides↗
PubMed1979

Molluscum contagiosum: the volcano phenomenon.

Molluscum contagiosum, a common cutaneous viral infection, responds to a variety of therapeutic modalities, but patient cooperation often limits the practitioner's choice. In an effort to provide minimally traumatic treatment for a four year old boy with this dermatosis, an interesting phenomenon was chanced upon, which greatly facilitated therapy.

Anesthesia, Local↗