A M Artale | PubMed Health

PubMed1993

Intraoperative histopathologic nerve examination in brachial plexus injury.

A new method of indirect intraoperative evaluation of axonal quality in a proximal nerve stump by immediate observation of the myelin sheath is presented. Using this method in 18 cases of brachial plexus injuries, the proximal stumps of particular roots or trunks were classified as unfavorable, favorable, or fair. This histologic grading was compared to the clinical result obtained after surgical repair of these nerves in the corresponding territory. In three cases, the proximal stump of the brachial plexus root was sacrificed because of an unfavorable grade, and a nerve transfer was performed: the results were useful in two cases and "academic" in one case. Among 12 cases with favorable histologic grades, nine were associated with useful function and three were "academic". Among three cases with a fair histologic grade, two were associated with an "academic" result and one was useful in a nine-year-old child. Retrospective comparison with classic examination after axon staining showed that intraoperative histopathologic grading was somewhat too optimistic in six cases and was relevant in 12 cases. This method may be helpful in choosing proper methods for brachial plexus repair. A normal or almost normal histopathologic condition in the proximal stump of the nerve is mandatory for obtaining a useful clinical result after repair.

Adolescent↗

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[Ozone therapy in lumbar sciatic pain].

INTRODUCTION: Medical ozone is a mixture of oxygen and ozone which can be used for several medical applications. Ozone was first applied clinically to the treatment of lumbar sciatic pain peridurally, while Pietrogrande was the first in Italy to report on its intradiscal administration to treat nucleus polposus herniation. On account of these considerations, we have decided to introduce this method in our Institute (I.C.O.T. Latina) as an alternative to surgery in the treatment of lumbar sciatic pain supported by an intradiscal hernia. MATERIAL AND METHODS: September, 1995, to April, 1997, we treated more than 1000 patients with intradiscal ozone infiltration. We prospectively analyzed the first 50 patients, with 6 months' follow-up at least; all of them were preliminarily submitted to clinical examination, electromyography, CT and MRI. After local anesthesia, we injected the disk, with 18-20 G needles and under CT or fluoroscopic guidance, with 12 ml of a mixture of oxygen and ozone at a concentration of 20-30 micrograms/ml. The treatment was repeated two or three more times at intervals of 3, 15 or, when necessary, 30 days. After each treatment, CT follow-ups were carried out and the final follow-up was made 3 months later. RESULTS: We divided our results into clinical and instrumental. As for clinical response, we had 68% positive results (40% excellent, 28% good) and 32% negative results (10% of patients underwent surgery and 22 are under medical and physical treatment). As for CT response, we had 82% positive results (36% excellent, 46% good), while no major changes between pre- and post-treatment CT findings in the remaining 18% of cases. CONCLUSIONS: Ozone therapy, thanks to its ease of execution and noninvasiveness, permits the successful outpatient treatment of lumbar sciatic pain. Moreover, the lack of major complications and the good results obtained compared to other methods, such as chemonucleolysis, percutaneous automated discectomy, microsurgery and conventional surgery, suggest that ozone therapy can be considered the treatment of choice for lumbar sciatic pain and a valid alternative to surgery in many cases.

Adult↗