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Biomedical subjects

A M Baru

Publications and source records attributed to A M Baru.

14 recordsLinked to original sources
PubMed1977

[Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect].

Experiments on male-rats with a chronic administration of lithium show that it exerts a dose-dependence ambivalent action on the biochemical and behavioural characterisics of "reseprine depressions". In this way changes in the catecholeamine excretion and disturbances of conditioned reactions of advoidance are prevented (in dosages 10 mg/kg , and increasing them to 50 mg/kg). An opposite influence of different doses of lithium was also seen in a study of the hypothalamic resources of noradrenalin in the remote period of an after action of reserpine. The use of lithium exerts an expressed preventive effect in experimental emotional stress, preventing the development of suprarenal reactions and disorders of conditioned reflexes of avoidance. The authors discuss some neurochemical mechanisms of ambivalent and emotiotropic effect of lithium and the exedience of an enlargement of its prophylactic use.

Adrenal Glands↗
PubMed1975

[Changes in the noradrenaline level and synthesis of nuclear RNA in the brain of rats with disturbances of the emotions and conditioned-defense behavior].

Brain noradrenaline (Na) exhaustion in reserpine-, disulfiram-or diethyldithio carbamate-treated rats was followed by a fall of the nRNA synthesis, emotional and conditioned behaviour disturbances. In accumulation of cerebral NA (ipraside and imipramine injections) there is an increase in the rate of synthesis, of the nuclear RNA. Prevention of the exhausting effect of reserpine by a preliminary injection of ipraside also prevented disturbances of the nuclear RNA synthesis.

Affective Symptoms↗
PubMed1975

[Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)].

By a combination of biochemical and pharmacodynamical analyses the author conducted a differentiated study of the role of separate neurohormones (adrenalin, noradrenalin, dopamine, serotonine) and their interconnection with other regulating systems (corticosteroids, nucleic acids) in the neurochemical structure of experimental models in depressive behaviour (reserpine depressions, depressions due to inhibitors of dopamine-beta-oxydase). In the aspect of the author's concept concerning reciprocity of relationships between the central and peripheral catecholamine mechanisms on the basis of the obtained experimental data, their comparison with the previous clinico-biochemical investigations and literary data is considered to be the pathochemical basis of depression. This is considered to be a multicomponent structure of pathologically fixed changes of the central noradrenergic activity, relationships in the catecholaminergic system (hypothalamus--medullau substance of the adrenal glands) and processes of reswitching catecholamine influences on the state of other neurochemical regulatory systems.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[RNA synthesis in rat brain during pharmacological modification of norepinephrine metabolism].

Norepinephrine metabolism and nuclear RNA (nRNA) synthesis in the rat brain are found to be conjugated. Under the effect of preparations inducing a disturbance in the norepinephrine (sodium diethyldithiocarbamate and reserpine) its content in the brain tissue lowers and the nRNA synthesis intensity decreases. Accumulation on total resources of norepinephrine in the brain under the effect of ipraside or its synaptic form (melipramine, Lu-5) intensifies the nRNA synthesis.

Animals↗
PubMedDate not supplied

[Catecholamine storage in schizophrenia].

After administration of isadrine excretion of noradrenaline was increased in schizophrenic patients with symptoms of depression or anxiety. This phenomenon was not observed in healthy persons and in patients with circular depression. Data on liberation of noradrenaline by other amines in schizophrenia and displacement of noradrenaline in schizophrenia by isadrine, which does not accumulate in normal storage sites, suggest that storage of noradrenaline is impaired in schizophrenia.

Anxiety↗