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Biomedical subjects

A M Bennett

Publications and source records attributed to A M Bennett.

46 records · Page 3Linked to original sources

Natural and experimental pox virus infection in the domestic cat.

Three naturally occurring cases of cowpox virus infection in the domestic cat are described. Isolate L97 was identified as cowpox virus on the basis of morphology, serology and characteristic cytopathic effect in tissue culture and on the chorioallantoic membrane of embryonated eggs. All three cases showed multiple skin lesions, slight conjunctivitis or purulent ocular discharge but there were no respiratory signs. Two animals recovered, the third was put down as a stray. The disease was reproduced in experimental cats. Isolate L97 was inoculated into two cats intravenously and two cats by skin scarification. All four developed skin lesions at the site or sites of inoculation, and in one cat multiple lesions developed. The two intravenously inoculated animals also developed severe oedema of the neck and brisket around the site of inoculation into the jugular vein, and one cat died. Serological and pathological findings on both the natural and experimental infections are described. Serum neutralising antibody titres in both natural and experimental early convalescent cases were significantly enhanced by the addition of complement.

Animals↗

Lobular dissecting hepatitis in the dog.

Ascites and acquired portosystemic shunts were consistent findings in six dogs with a chronic hepatitis of unusual morphology and unknown etiology. The hepatitis was characterized by a mixed inflammatory infiltrate and dissection of the lobular parenchyma by reticulin and fine collagen fibers. While limiting plates were disrupted by this process, portal inflammation was inconstant and seldom marked. Biopsy samples generally had very small, sublobular regenerative nodules, but larger nodules sometimes were present postmortem. Dilated vascular channels, representing sinusoids and portal venous radicles were a prominent feature of most affected livers. The lesions differ from previously documented chronic hepatitis in the dog, and from the chronic hepatitides in man.

Animals↗

An outbreak of hepatitis in marmosets in a zoological collection.

12 marmosets of 3 different species died of hepatitis during a period of 5 months. The lesions closely resembled those of virus hepatitis in man but material from these animals and from in-contact marmosets failed to reveal the presence of hepatitis A. This together with certain aspects of the epidemiology of the disease suggests that the outbreak was not caused by a virus of human origin but possibly by a virus indigenous to the marmoset or tamarin.

Animals↗

Large intestinal biopsies from normal dogs.

Proctoscopic examination and rectal and colonic biopsies were performed in 10 clinically normal dogs. There was some variation between individuals in the gross and light microscopic appearance of normal canine large intestine but the findings were distinct from those in disease.

Animals↗

Placental lesions in habitually aborting cats.

An ovariohysterectomy was done on five female cats with a history of habitual abortion in the 3rd to 4th week of pregnancy and the foetuses and placentas examined. Histologic and electron microscopic examination showed multifocal placental necrosis which was deduced to begin in the syncytial trophoblastic cells and to extend to all the cells of the labyrinth. This lesion was followed by foetal autolysis. No bacterial, viral or mycoplasmal agents could be incriminated in the disease.

Abortion, Habitual↗