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Biomedical subjects

A M Bidabé

Publications and source records attributed to A M Bidabé.

At least 19 recordsLinked to original sources
PubMed1999

Bilateral decrease in interictal hippocampal blood flow in unilateral mesiotemporal epilepsy.

OBJECT: The goal of this study was to determine whether regional cerebral blood flow (rCBF) changes that were found contralaterally to a verified unilateral epileptic focus were associated with the spatiotemporal organization of epileptic abnormalities. METHODS: The CBF in both hippocampi was assessed using stable Xe-enhanced computerized tomography in a series of 19 patients with unilateral mesiotemporal epilepsy. Results were compared according to the distribution of interictal spiking and the spatiotemporal organization of the ictal discharges as determined by stereoelectroencephalography. Two groups were defined: in Group 1 (nine patients), the discharge remained unilateral; in Group 2 (10 patients), the discharge spread to contralateral mesiotemporal structures. For Group 1, the rates of ipsi- and contralateral hippocampal blood flow (HBF) were 32.88+/-15.53 and 45.88+/-17.19 ml/100 g/minute, respectively, whereas in Group 2 they were 36.7+/-11.54 and 36.4+/-11.27 ml/100 g/minute (mean+/-standard deviation). A two-way analysis of variance combining type of seizure (Group 1 compared with Group 2) and HBF (ipsi- compared with contralateral absolute values) demonstrated a main effect for HBF (F[1,17] = 5.051; p = 0.0382), a significant interaction between the two factors (F[1,17] = 6.188; p = 0.0235), and no main effect for type of seizure (F[1,17] = 0.258; p = 0.6178). CONCLUSIONS: In unilateral mesiotemporal epilepsy, asymmetrical interictal hippocampal perfusion was correlated with restricted unilateral ictal discharges, whereas bilateral hippocampal hypoperfusion was correlated with ictal discharges spreading to the contralateral mesiotemporal structures. The lack of correlation between the degree of hypoperfusion and the percentage of neuron cell loss indicated that the decrease in rCBF has both functional and lesional origins.

Adolescent↗
PubMed1996

Regional cerebral blood flow measurements with Xenon-CT in the prediction of delayed encephalopathy after carbon monoxide intoxication.

Reported evaluations of CBF with Xe/CT were performed in 11 patients during the lucid interval following CO intoxication. Results were compared with clinical and SPECT data. Two patients developed neuropsychiatric behavior (delayed encephalopathy) one month following the initial recovery. The symptoms persisted in one of them 15 months later. Their CBF values as well as those in most of the other patients, monitored at the basal ganglia and white matter areas, were in relation with the clinical outcome, However, further studies with a larger number of patients, are needed to confirm the predictive significance of Xe/CT measurements for the long term sequelae of CO poisoning.

Adult↗
PubMed1993

Effects of nimodipine on posttraumatic spinal cord ischemia in baboons.

Posttraumatic ischemia appears to be largely responsible for the extension of lesions in acute injury of the spinal cord. In the present study, we have evaluated the putative improvement of axonal function by the calcium channel blocker nimodipine after acute trauma of the spinal cord. Three techniques were used: (1) spinal cord blood flow (SCBF) using a scanographic technique with stable xenon, (2) somatosensory evoked potentials (SEPs), and (3) magnetic resonance imaging (MRI). Thirteen baboons were used in this study. Acute trauma was achieved by compression of the spinal cord at level L1 by applying pressure for 5 sec with an inflated balloon catheter injected with Ringer's solution. Following the injury, one group (n = 5) received a saline infusion (placebo) for seven days, and a second group (n = 8) received a nimodipine infusion (0.04 mg/kg/h) during the same period of time. SCBF and SEP were first recorded prior to trauma. SCBF, SEPs, and MRI were then recorded on the day of the injury and eight days prior to histologic examination of the spinal cord. In these studies nimodipine significantly improved SCBF. The decrease in SCBF observed at day one and day eight following trauma was significantly reduced in the treated group. Two baboons in the treated group also showed improvement of axonal function as assessed by SEP. No significant difference was observed with MRI, however, histologic study revealed that the lesions were significantly smaller in the treated group. Based on these observations we conclude that a week of nimodipine treatment following spinal cord injury enhances SCBF, limits the size of the spinal cord lesion, and perhaps improves functional recovery.

Animals↗
PubMed1992

[Methods for measuring spinal cord blood flow].

This study aimed to review the techniques used most currently for measuring spinal cord blood blow flow (SCBF) in animals, i.e. the hydrogen clearance, labelled microspheres, 133Xe clearance and 14C-antipyrine autoradiographic methods. All four techniques may only be used in animals, because of their invasiveness. Flow figures varied greatly with the method, the spinal level at which measurements were carried out, and the species of animal. However, results tend to suggest that SCBF is very similar to cerebral blood flow in that it is controlled by chemical, autoregulatory and metabolic factors. Approaches to measuring SCBF in man may be made using stable xenon-enhanced computed tomographic imaging (Xes-CT) in the same way as for measuring cerebral blood flow. The calculation of SCBF is based on Fick's principle transformed by Kety and Schmidt. After a reference CT section has been obtained, twelve 8 mm thick sections are carried out whilst the patient breathes a 30% xenon-70% air/oxygen mixture. This series of views enables the SCBF to be calculated in four steps. Quantitative analysis in eight human subjects gave a mean SCBF of 58.8 +/- 5.96 ml x 100 g-1 x min-1. However, this method has a low signal to noise ratio. Moreover, the qualitative analysis of the parametric views of flow demonstrate tissue heterogeneity, partly due to the patient's movements (breathing movements). However, the method is non invasive, safe, and reproducible. As it can measure very low values of blood flow, the study of ischaemic spinal lesions is made possible, although some technical and software improvements are still required.

Adult↗
PubMed1990

Measurement of cerebral blood flow by the stable xenon computerized tomography method.

Measurement of cerebral blood flow (CBF) by computerized tomography (CT) is a three-dimensional method with better spatial resolution than the two-dimensional methods. Its principle was first described by Drayer et al. in 1978, with stable xenon (Xes) as CBF indicator. CBF quantitation is based on Fick's principle transformed by Kety and Schmidt when the indicator is a diffusible inert gas. Xes concentrations in cerebral parenchyma and arterial blood are the initial parameters in Kety's equation; they are expressed as variations in attenuation coefficient. Examinations are performed with a Somatom DRH (Siemens) apparatus. Xes (35%) is inhaled from a closed circuit ventilation system which enables xenon to recirculate. From a console connected to the inhalator the operator can command gas preparation, start examination, acquire and transfer data. A reference ("native") section is cut at the site chosen on the topogram. Twelve sections, each 8 mm thick, are then performed while the patient inhales, during 6 minutes, the mixture: air-35% xenon + 65% oxygen. The series of images which enable the CBF parametric image to be calculated is treated in four stages: 1. Xenon concentrations in arterial blood are calculated from the Xes values measured in the air exhaled at the end of expiration. 2. All contrasted sections are visualized on the image monitor after subtraction of the background noise. 3. The CBF parametric image is calculated by Koeppe's optimization method (linear calculation of least squares), using a PDP 11/44 processor. 4. The CBF parametric image is treated to give the CBF value expressed as ml.100 g.min. The method has its limitations: it depends on the limited signal/noise ratio and on the patient's complete immobility; cerebral metabolic rates cannot be measured. But these limitations are largely outweighed by major advantages: the CT/Xes method is non-invasive, safe and reproducible. Owing to its excellent spatial resolution, it provides very accurate maps of superficial and deep regional blood flows. As it measures very low blood flows and can give partition coefficient values, it is of considerable help in the study of ischaemic and degenerative cerebral pathologies.

Adult↗
PubMed1990

[Protocol for preparation, anesthesia and monitoring in therapeutic angiography].

The procedures involved in cerebral and medullary embolization produce special problems for the anesthesiologist. Some imperatives must be followed in order to minimize the high neuroradiological risks associated with these long and repetitive procedures. The first of these imperatives is sedation, which throughout the procedure should be sufficient, although not narcotic enough to prevent neurological evaluations. The use of a benzodiazepine (Midazolam) in conjunction with an analgesic (Alfentanil) that is rapidly eliminated answers this need. The prescription of vasodilatator agents depends on the location of the embolization. Calcium channel blockers should be used following embolism of the internal carotid while nitrate derivatives are recommended after embolism of the external carotid. Reduction of the risk of thrombosis is accomplished by perfusion with anti-sludge or, with exception to therapeutic procedures involving hemostasis, by perfusion with acetylsalicylic acid. Following evaluation of 105 procedures in 75 patients it is concluded that this sedation produces reliable results and allows the procedure to be performed with maximal security.

Adolescent↗
PubMed1984

[Bilateral choanal atresia in the newborn infant. Role of the anesthesiologist].

Congenital bilateral atresia of the choana is a rare anomaly. It is a closure of the posterior nares by a membranous and/or osseous partition. It causes early respiratory distress in the neonate. The history and presenting symptoms seldom cannot simulate those of severe respiratory distress in the newborn. The anaesthesist can easily make the diagnosis when he observes a "cyclic pattern of respiratory distress": chest retraction and cyanosis which disappear with crying. The purpose of this present case is to emphasize both anaesthetic and surgical approaches to the management of this type of lesion.

Anesthesiology↗