[Chemical intoxication syndrome in children with diffuse alopecia].
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Biomedical subjects
Publications and source records attributed to A M Bukharovich.
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A patient with primary follicular mucinosis is described, who developed multiple foci of involvement on the skin of the trunk and limbs. Combined therapy including thyroidin and liver function-normalizing drugs was fairly effective.
Transmission of herpes zoster infection from one sister to the other is described, resultant from close everyday contacts. Clinical manifestations of the disease (severity, dissemination, course and type of involvement) were much more marked in the elder sister, suffering from disseminated Darier's dyskeratosis and marked debility. Herpes was complicated with vasculitis, necrosis, Pseudomonas aeruginosa infection, development of pneumonia and keratitis. Problems of treatment of such patients are discussed.
Carbohydrate metabolism has been examined in 301 patients with chronic pyoderma over the course of combined therapy including sugar-reducing drugs; biochemical methods (measurement of the blood sugar on an empty stomach, Staub-Traugott double carbohydrate load test, measurement of the blood serum seromucoid) and radioimmunoassay of the blood serum immunoreactive insulin have been employed. Diabetes mellitus has been first diagnosed in 2.9% of patients, latent diabetes in 18.8%, and in 4.7% of the examinees the parameters indicate the risk of this condition development. Combined therapy improves the examined parameters, providing good immediate and late results. These data favor the use of sugar-reducing agents in multiple-modality therapy of patients with chronic pyoderma.
Two patients with secondary new syphilis are described, abusing alcohol, developing early syphilitic hepatitis. The manifestations of this condition are similar to those of viral hepatitis. This necessitates a thorough examination of the skin integument, visible mucosae, genitals and perianal area, and of the peripheral lymph nodes in the patients with suspected viral hepatitis, in order to timely detect a possible liver involvement in Treponema infection. When such patients consult a doctor, specific serologic tests should be carried out and case history be carefully recorded.
Tomicide paste is a highly effective agent in combined therapy of patients with primary and secondary pyoderma. Tomicide is recommended for practical dermatology in the liquid form for sanitization++ of infection foci in nasopharyngeal organs and in paste with a 10% concentration of the agent. This paste is also advised for cases with secondary pyoderma complicating the course of neurodermatitis and chronic eczema not liable to weeping.
The authors give their comments on the paper by A. A. Kalamkarian and V. A. Samsonov on the taxonomy of diffuse neurodermatitis and atopic dermatitis. They consider that the term "atopic disease" is more validated; discussing the wording of a detailed diagnosis, they come to the conclusion that the term "diffuse" should be used only as a characteristic of the process dissemination in neurodermatitis.
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