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Biomedical subjects

A M Cirla

Publications and source records attributed to A M Cirla.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Occupational exposure to volatile anesthetics and reproductive effects: a bibliographic review of epidemiological studies].

Up to the early eighties, a variety of epidemiological studies suggest that chronic exposure to low doses of anesthetic gases, as occurs in operating rooms, is an occupational risk factor for spontaneous abortion and congenital defects. Numerous and more recent epidemiologic studies are reviewed; currently it is suggested that there is inadequate evidence to conclude that occupational exposure to anesthetic gases causes increased rates of spontaneous abortion or congenital anomalies. The improvement of environmental conditions, that has reduced airborne levels of anesthetic gases in operating rooms, has been critical in reducing the risk of abortion and congenital defects. In agreement with recent epidemiological reports, we believe that the health surveillance of exposed workers must include the study of pregnancy outcome.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

[Evaluation of the risk of anesthetic gases to exposed subjects with different tasks in operating rooms].

A research was carried out on risk evaluation of workers with different tasks in operating theatre. The airborne concentrations were determined by an IR analyzer with two distinct sampling lines: the first was placed in surgical zone and the second one in anesthesiological zone. The anesthetists resulted more at risk than surgical team. Nevertheless when the evaluation was based on N2O urinary concentration and data were stratified according to task a prevalent inhalation absorption resulted for non medical staff (instrumentist and professional nurse). Our data concerning N2O ranged between 95-764 ppm indoor and between 3-92 mcg/l in the urines of exposed subjects.

Anesthesia, Inhalation↗
PubMedDate not supplied

[Risk of infectious hepatitis and risk of anesthetic gases in operating rooms: considerations on 3 cases of chronic hepatic pathology].

Three subject with professional activity in operating theatre and with a diagnosis of chronic viral "C" hepatitis are considered. All cases (Two surgeons and an anesthetist) had been continuously exposed to low level of airborne anesthetic compounds (Nitrous oxide and halogenated compounds). According to possible, but not proved, synergic effects, two cases with a clinical picture of active chronic hepatitis were classified as unqualified to specific work. The third case, affected by a persistent chronic hepatitis, was admitted to operating activities only for four hours a week, i.e. only an operating session a week. Hepatitis B and C markers must be always monitored during the medical surveillance in exposed people of operating theatre.

Air Pollutants, Occupational↗
PubMedDate not supplied

Epidemiological study on workers exposed to low dimethylformamide concentrations.

Reviewing medical and epidemiological reports, no definite clinical picture could be expected as a result of a low DMF exposure and experimental research on long term toxicity has always demonstrated some adverse effects but has not been sufficient to define a no-effect level in animals. This study was designed to assess the specificity of symptoms and the relevance of adverse effects as consequence of an exposure to airborne DMF concentration in the range of the present TLV (30 mg/m3 - 10 ppm). For this purpose 100 DMF-exposed workers, with homogeneous characteristics, were compared with 100 matched controls. Both groups were selected by a careful pair-matching. Mean DMF exposure was 22 mg/m3 (range 8-58 mg/m3). Exposed subjects and their matched controls were evaluated clinically and a questionnaire was used for the registration and the comparison of subjective complaints. A laboratory assessment was performed, including transaminase and gamma-glutamyl transpeptidase. Statistical analysis was based on McNemar Test procedure. The problem of dietary alcohol intake was particularly investigated. Among symptoms studied, headache, dyspepsia and digestive impairment of hepatic type could be specifically associated with chronic DMF exposure and increased levels of gamma-GT demonstrated minimal hepato-cellular damage, even without ethanol dietary intake. No chronic sickness was diagnosed and the disturbances observed are better considered as indicators of malaise and discomfort due to a toxic effect of DMF, whose consequences are discussed.

Adult↗
PubMedDate not supplied

[Specific bronchostimulation tests in occupational medicine].

A review of the literature about specific bronchial provocation tests in occupational asthma was made. The Authors focus on some problems related to the methods of exposure; furthermore, in separate chapters the bissynosis and the relationship between specific and aspecific hyperresponsivity are dealt with. The Authors conclude that it is necessary a standardization of the methods for the reproducibility of the tests, and, as in aspecific hyperresponsivity, so also the specific responsivity may be quantified in dose-response curves.

Allergens↗