The placenta as a possible source of gut peptide hormones.
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Adult↗
Biomedical subjects
A M Ebeid
Publications and source records attributed to A M Ebeid.
The effect of normalization of plasma amino acids on hepatic encephalopathy in man.
Previous work from this laboratory has suggested that the plasma amino acid pattern, known to be deranged in hepatic encephalopathy, may be related causally. In order to test this hypothesis, 23% dextrose and a special amino acid solution whose components were calculated to normalize the plasma amino acid pattern were infused in 11 patients, eight with chronic cirrhosis and acute exacerbation (Group 1) and three patients with fulminant hepatitis (Group 2), in amounts of up to 120 Gm. of protein equivalent per 24 hours. Plasma amino acids were abnormal but different in both groups. In Group 1 (cirrhosis) changes in plasma amino acid pattern including elevated phenylalanine, tyrosine, glutamate, aspartate, and methionine and decreased valine, leucine, and isoleucine. In Group 2 all amino acids were elevated, with the exception of the branched chains which were normal. Hepatic encephalopathy improved in all patients in Group 1 and in one of three patients in Group 2 following the infusion. The ratio (see article) showed an excellent correlation with a grade of encephalopathy. When this ratio, previously 1.0 in the presence of encephalopathy, returned to the normal value near 3.0 to 3.5, encephalopathy improved. An excellent correlation was obtained between the ratio and the grade of encephalopathy and was dose related as well. The results suggest that different amino acid patterns in hepatic encephalopathy of differing etiologies require treatment modalities which may differ for the two types of encephalopathy. Whereas amino acid infusion appears to be a valuable, efficacious way of providing nutrition in treating hepatic encephalopathy in patients with cirrhosis and acute deterioration and coma, other means of therapy such as plasms "laundering" appear to be necessary in patients with fulminant hepatitis.
Adult↗
A simple comprehensive anaesthetic record sheet.
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Anesthesia↗
A maneuver to improve the shutter mechanism in inguinal hernias.
A technique for improving the shutter mechanism in the treatment of inguinal hernias is presented. The lateral leaf of the external oblique is fashioned to accommodate the emerging spermatic cord and is brought to a more posterior plane by suturing it to the inguinal ligament. This supporting flap is anchored to the internal oblique aponeurosis and anterior rectus sheath, keeping the sutures deep to the internal oblique, but superficial to the transverse plane.
Adult↗