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Biomedical subjects

A M Geursen-Reitsma

Publications and source records attributed to A M Geursen-Reitsma.

8 recordsLinked to original sources
PubMed1992

Sensitization to azo dyes: negative patch tests to yellow and red azo dyes in printed paper.

An over 2 x fold increase in para-aminoazobenzene allergy was observed in patients with allergic contact dermatitis during the years 1990-1991. Presuming that an increase in colour-printed newspapers might be a new unrecognized source of clinical allergy to azo dyes, patch tests were performed in 32 patients with an established p-aminoazobenzene allergy using a series of important azo dyes used in offset printing ink (Pigment Yellow 12, Pigment Yellow 13, Pigment Red 53, Pigment Red 57), as well as with dye-containing inks and specimens of colour-printed newspaper containing these azo dyes. In 25 out of the 32 patients (78%), positive patch tests were seen to textile azo dyes, in particular to Disperse Orange 3 (24 patients). In none of the 32 patients were reactions observed to the azo dyes used in printing ink, to the inks used or to the colour-printed paper specimens, indicating that these products were apparently not a cause of contact dermatitis in our group of patients with azo dye sensitization.

Adult↗
PubMed1990

Sensitization to fragrance materials in Indonesian cosmetics.

2 different groups of patients were patch tested with 2 test series (A and B) containing extracts of fragrance raw materials, traditionally used in Indonesian cosmetics. Series A consisted of diluted extracts of commercially available Indonesian fragrances. Series B consisted of extracts prepared in our department from corresponding indigenous flowers and fruits. Group 1 consisted of 32 patients positive to fragrance-mix, of whom 8 (25%) had positive tests to 1 or more of the different extracts of fragrance raw materials. Reactions were observed to extracts of: Rosa hybrida Hort (7); Canangium odoratum Baill (5); Citrus aurantifolia Swingle (4); Jasminum sambac Ait (2). 6 of the 8 patients had reactions to 1 or more of the components of fragrance-mix: oakmoss (3); cinnamic alcohol (2), isoeugenol (1); cinnamic aldehyde (1) and geraniol (1). Group 2 consisted of 159 patients patch tested on suspicion of contact dermatitis, who were fragrance-mix negative. Only 2 (1.2%) had a positive patch test to the extracts of fragrance raw materials. Specimens taken (as is) from the flowers and citrus fruits (being the basis sources of the fragrance raw materials) were less antigenic. The use of additional test series in Indonesia to detect allergy to traditional cosmetics and perfumes merits further investigation.

Allergens↗
PubMed1989

Effects of topically applied glucocorticosteroids on patch test responses and recruitment of inflammatory cells in allergic contact dermatitis.

The effects of repeated topical application of a strong glucocorticosteroid (GCS) on patch test responses and the inflammatory infiltrate were studied in twenty nickel allergic patients. Patch test responses were strongly inhibited in 18 out of 20 patients. Immunohistochemical analysis revealed marked reductions in CD1+(T6+) Langerhans cells, activated inflammatory T cells and of mast cells in the skin. It is concluded that GCS suppress contact allergic responses by reduction, or functional inhibition of antigen presenting cells. The reduced number of mast cells release less vasoactive mediators, inhibiting recruitment of inflammatory cells.

Administration, Topical↗
PubMed1986

Sensitization to sodium hypochlorite causing hand dermatitis.

2 patients are reported with chronic hand dermatitis related to sensitization to sodium hypochlorite, as the active component in a bleaching product. To avoid irritant reactions in patch testing, a sodium hypochlorite concentration of 1.0% appeared to be useful. It is concluded that with regard to the frequent use of bleaching agents, allergy to sodium hypochlorite must be considered in certain cases of unidentified chronic allergic hand dermatitis.

Adult↗