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Biomedical subjects

A M Greco

Publications and source records attributed to A M Greco.

At least 37 records · Page 2Linked to original sources
PubMed1984

Effects of a purified diet enriched with animal protein on female rats. Preliminary report.

On account of many epidemiological data showing a definite correlation between mortality from heart disease and animal protein content in the diet, the effect of a 60 days purified diet enriched with casein and lactalbumin has been studied in rats. Although the experimental time was rather short, histological study of the organs has shown morphological alterations of liver, adrenal glands, heart, gastrocnemius muscle and kidney. Determination of some haematic parameters have revealed that from 15th day of diet glucose and triglycerides begin to increase moderately but significantly while azotemia is definitely high only after the 60th day. No changes vice versa were observed of cholesterol, creatinine and electrolytes level.

Adrenal Glands↗
PubMed1982

Correlation between chronic hypovitaminosis C in old age and plasma levels of cholesterol and triglycerides.

The possible interrelations between ascorbic acid, cholesterol and plasma triglycerides were studied in the residents of an old people's home. The study lasted about five months, from autumn to spring, and concerned 100 people in good health, both males and females, whose age varied from 70 to 84. Old people's diets proved well balanced and varied to such an extent as to supply them with a satisfying amount of calories and vitamin C. The results of this study showed that the average plasma levels of ascorbic acid [1] approached the lower level of normal values (587 +/- 34 micrograms %), [2] depended on sex (in fact it was significantly lower in males) (p less than 0.01), and [3] depended on diets which varied according to the different seasons when drawings were made (p less than 0.01). Moreover, in all cases there was a significantly negative correlation between ascorbic acid and cholesterol (p less than 0.05), whereas no significant correlation seemed to exist between ascorbic acid and triglycerides. On the contrary, a significant positive correlation between cholesterol and triglycerides was observed (p less than 0.01). The above-mentioned correlations seem to be valid only for males. This study confirmed by partial 3 variant correlations, produced results that point out the risk of hypercholesterolemia connected with chronic hypovitaminosis C, a characteristic feature of old age.

Aged↗
PubMed1982

[Evaluation of aldosterone, corticosterone, glucose and triglyceride blood levels in pregnant rats fed a high protein diet].

Pregnant rats, Wistar strain, fed a rich protein diet (row casein 40%, milk-albumin 20%) from the beginning or from the eighth day of pregnancy. The comparison with control rats, receiving an usual diet, showed that the high protein intake produced an expressive increase of haematic glucose and triglycerides and a very significant diminution of serum aldosterone and corticosterone, particularly when the experimental diet was begun from the first day of pregnancy. The Authors suppose a damage of adrenal cortex and intend to clarify in a next work this possibility by an histologic study.

Aldosterone↗
PubMed1982

Study of blood vitamin C in lung and bladder cancer patients before and after treatment with ascorbic acid. A preliminary report.

A systematic study of vitamin C blood levels in patients with cancer and an evaluation of their modifications when the patients were orally treated with daily large doses of ascorbic acid (5g/day) have been carried out. For excluding any interference on intestinal vitamin C absorption, all patients with digestive tract cancer have been excluded. Our first results concern 24 lung cancer and 35 bladder cancer patients, operable or not, of different sex and age. The study has shown hypovitaminosis C subclinic conditions for the greater part of subjects: in fact the average haematic rate of ascorbic acid approaches to lower level of physiologic range, appearing very low particularly for the younger patients. Periodic haematic dosages of vitamin C of unoperable and operated patients treated with large doses of ascorbic acid, have shown a rapid increase of its blood concentration which frequently has been very over 1500 micrograms%, the higher level of normal range. These high vitamin haematic levels, generally constant during the time, appear usefull in increasing the defence reactions of the cancerous patient.

Adenocarcinoma↗
PubMed1980

[Assay of brain and liver DNA, determination of body growth and of some blood parameters in rats subjected to protein malnutrition during fetal and post-natal development].

The Authors studied the effects of proteinic malnutrition when it occurred at various periods in the life of rats: the last 10 days of fetal life; nursing (the first 3 weeks of life); after weaning (up to 42 day). The results show that:--the growth in weight of the animals was severely restrained when protein deficiency occurred in post-natal life;--in any case, the blood levels of hematocrit, hemoglobin and proteins were significantly lowered;--organ functions and development were greatly compromised if malnutrition occurred during the period of their cell division. In fact, a brain damage, estimated by protein and DNA modifications, is the result of protein deficiency in pre-natal and, particularly, in nursing period. The hepatic damage, instead, becomes more evident in post-natal life and specially after weaning since the cell division in the liver continues for a much longer period of time.

Aging↗
PubMed1980

Relationship between hemorrhagic ocular diseases and vitamin C deficiency: clinical and experimental data.

The hematic level of ascorbic acid was significantly lower with respect to that of healthy subjects in 55 patients with hemorrhagic ocular diseases. Experiments on albino guinea pigs showed that an induced hypovitaminosis C (2 weeks of scorbutigenic diet followed by a maintenance dose of 0,5 mg of ascorbic acid) caused the appearance of widespread retina hemorrhages and a significant decrease of the blood ascorbate levels with respect to the control groups. The present results suggest that a prolonged insufficient dietary intake of ascorbic acid may give rise to hemorrhagic ocular pathologies in humans.

Adult↗
PubMed1979

[Effect of diet with different protein content on rats during gestation: repercussion on pregnancy development and litter size. Preliminary note].

Pregnant rats, Wistar strain, were treated from day 11 of gestation with synthetic diets containing different amounts of protein. The Group of rats fed a severely deficient protein diet (4% of casein, 2% of lactalbumin) showed reduced hematocrit, hemoglobin, total protein and an expressive increase of gamma globulins compared with rats treated with normal or elevated protein levels. Weight gain during pregnancy was higher for rats which received a larger amount of protein; on the contrary those that were subjected to malnutrition had no weight gain and bore prematurely with high percent of foetal mortality.

Animals↗
PubMed1979

[Thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient Nath diet].

The administration of drinking-water, added with LiCl (20mg Li+/l) to rats fed on "atherogenic" diet without cholesterol (casein 20% hydrogenated coconut oil 25%, sucrose 49.1%) for 90 days, elicits an expressive diminution of haematic lipids (triglycerides, free fatty acids, total cholesterol) and hepatic cholesterol. The serum dosages of thyroid hormones T3 and T4 show that the Li+ concentration used in the experiment do not inhibit the glandular functions.

Animals↗
PubMed1978

[Modification in lipoproteins and hepatic and fecal cholesterol levels induced by exogenous lithium in rats on an atherogenic diet].

Rats fed atherogenetic diet and drinking-water containing a well known Li+ concentration show, in comparation to atherogenetic rats which do not receive lithium, an expressive reduction of haematic lipids and hepatic cholesterol with a contemporaneous cholesterol increase in stools. Lipoprotidogram examinations prove that exogenous Li+ is able to prevent the haematic lipoproteins alterations produces by atherogenetic nourishment; electrophoretic pattern of these animals is indeed the same of the one obtained for rats fed usual basal diet and drinking-water.

Animals↗
PubMed1975

Preliminary purification and dosages of the erythropoietic factor from ox-spleen.

The administration of ox-spleen homogenate, whether in rats made polycythemic by blood transfusion or in mice polycythemic by hypoxia, elicited a significant stimulatory effect on the rate of erythropoiesis. This activity remained unchanged even if the spleen, before being homogenized, was exhaustively washed with isotonic buffer pH 7.4 up to the total blood elimination.

Animals↗