Biomedical subjects

A M Holroyd

Publications and source records attributed to A M Holroyd.

10 recordsLinked to original sources

PubMed1987

A method for demonstrating subclinical inguinal herniae in patients undergoing peritoneal dialysis: the isotope 'peritoneoscrotogram'.

We report six patients who presented with genital oedema associated with continuous ambulatory peritoneal dialysis (CAPD) who had no clinically detectable inguinal hernia at the time of initial presentation. In the absence of conventional clinical signs of an inguinal hernia, isotope imaging of the pelviscrotal region after introducing technetium-labelled tin colloid through the dialysis tube has proved to be an accurate guide to localisation of the hernia, has avoided unnecessary bilateral explorations, and has facilitated early repair of the hernia, thus allowing reinstitution of CAPD.

Edema↗

PubMed1984

Is bile reflux at endoscopy a significant finding?

Postprandial duodenogastric reflux (DGR) was assessed scintigraphically in 10 patients with postprandial dyspepsia and endoscopic evidence of bile reflux (EBR) and in two control groups comprising seven patients with similar symptoms but normal endoscopic findings and 10 asymptomatic subjects without gastrointestinal pathology. DGR of iminodiacetic acid (IDA) after a liquid Lundh meal (250 ml) was assessed dynamically with 1 minute scintiscans and DGR expressed as the percentage of IDA secreted by the liver which appeared in the gastric region. DGR varied from 0-5% in asymptomatic controls and from 0-6% in dyspeptics without EBR. DGR in patients with EBR ranged from 0-16% but only two of 10 had values outside the normal range (0-5%).

Bile Reflux↗

PubMed1983

A single isotope method of post-prandial duodenogastric reflux assessment using 99Tcm-labelled IDA in patients with gallstones.

A technique for the quantitative assessment of post-prandial duodenogastric bile reflux is described using a single isotopes 99Tcm and a single-channel large-field gamma camera with a data processing system. The stomach is localised with pertechnetate prior to IDA administration and duodenogastric reflux is calculated as the percentage of hepatic IDA output reaching the stomach after correction for background activity and hepatic overlap. The technique has been validated, and used to study reflux in 25 patients with gallstones and in 10 control patients. Gall bladder function was assessed with an oral cholecystogram. Marked reflux (greater than 7%) occurred in 5 out 9 patients with a non-functioning gall bladder but in no controls and in none of 16 patients with gallstones in a functioning gall bladder. When patients were studied again after cholecystectomy, 2 patients with normal functioning gall bladders had developed marked reflux while those with preoperative reflux continued to reflux after cholecystectomy. Symptoms of gallstone dyspepsia before operation were more severe in those with marked reflux than those without. Surgery improved these symptoms even in those who continued to reflux after operation.

Adult↗

PubMed1980

The measurement of arterial perfusion of the liver in man using the radioisotope xenon-133.

The washout from the liver of xenon-133 injected into the thoracic aorta of human subjects undergoing cardiac investigation was monitored externally with a sodium iodide scintillation detector. The washout curve displayed an initial peak of activity, followed by a brief decline, and then a second, slower rise. The initial peak was thought to be due to isotope arriving in the liver via the hepatic artery, and the second rise due to isotope arriving via the portal vein. A method of analysis is presented which uses the height of this arterial peak to calculate arterial perfusion of the liver.

Hepatic Artery↗

PubMed1978

A preliminary study of the dynamics of resolution of experimental haematomas: radioisotope studies in animals.

A preliminary investigation was carried out in order to establish a method for the study of experimental haematomas. For this purpose haematomas were produced in rabbits by subcutaneous injection of rabbits' own blood after labelling the various blood components with appropriate radioisotopes. In addition, radioisotope labelled human serum albumin and fibrinogen were studied. The results show that there is considerable variation in the rate and pattern of dissipation of the various components of the experimentally produced haematoma. The significance of these findings is discussed.

Animals↗

PubMed1975