A M Kafy | PubMed Health

PubMed1988

Antioxidant effects of exogenous polyamines in damage of lysosomes inflicted by xanthine oxidase or stimulated polymorphonuclear leucocytes.

Active oxygen species produced by the action of xanthine oxidase or stimulated guinea-pig polymorphonuclear leucocytes have a lytic action of lysosomes possibly due to lipid peroxidation. Polyamines give some protection against lysis with putrescine being the most effective polyamine. The possible relevance to inflammatory disease is discussed.

Acid Phosphatase↗

PubMed1986

In vitro interactions between endogenous polyamines and superoxide anion.

Endogenous polyamines with anti-inflammatory activity scavenge superoxide and possibly other oxy-radicals produced by xanthine oxidase or from stimulated polymorphonuclear leucocytes. Polyamines incubated with stimulated cells are in part metabolised. Putrescine is converted to metabolites tentatively identified as gamma-aminobutyraldehyde, delta'-pyrolline and gamma-aminobutyric acid. The metabolism of spermidine, spermine and cadaverine was not as extensively studied but metabolites were formed that gave positive reaction to Schiffs reagent on tlc plates. The possible relevance of the results to the anti-inflammatory action of polyamines is discussed.

Animals↗