Biomedical subjects

A M Leshansky

Publications and source records attributed to A M Leshansky.

3 recordsLinked to original sources

PubMed2006

Actin-based propulsion of a microswimmer.

A simple hydrodynamic model of actin-based propulsion of microparticles in dilute cell-free cytoplasmic extracts is presented. Under the basic assumption that actin polymerization at the particle surface acts as a force dipole, pushing apart the load and the free (nonanchored) actin tail, the propulsive velocity of the microparticle is determined as a function of the tail length, porosity, and particle shape. The anticipated velocities of the cargo displacement and the rearward motion of the tail are in good agreement with recently reported results of biomimetic experiments. A more detailed analysis of the particle-tail hydrodynamic interaction is presented and compared to the prediction of the simplified model.

Actins↗

PubMed2005

Chaos and threshold for irreversibility in sheared suspensions.

Systems governed by time reversible equations of motion often give rise to irreversible behaviour. The transition from reversible to irreversible behaviour is fundamental to statistical physics, but has not been observed experimentally in many-body systems. The flow of a newtonian fluid at low Reynolds number can be reversible: for example, if the fluid between concentric cylinders is sheared by boundary motion that is subsequently reversed, then all fluid elements return to their starting positions. Similarly, slowly sheared suspensions of solid particles, which occur widely in nature and science, are governed by time reversible equations of motion. Here we report an experiment showing precisely how time reversibility fails for slowly sheared suspensions. We find that there is a concentration dependent threshold for the deformation or strain beyond which particles do not return to their starting configurations after one or more cycles. Instead, their displacements follow the statistics of an anisotropic random walk. By comparing the experimental results with numerical simulations, we demonstrate that the threshold strain is associated with a pronounced growth in the Lyapunov exponent (a measure of the strength of chaotic particle interactions). The comparison illuminates the connections between chaos, reversibility and predictability.

Journal Article↗

PubMed2005

Nonlinear rupture of thin liquid films on solid surfaces.

In this letter we investigate the rupture instability of thin liquid films by means of a bifurcation analysis in the vicinity of the short-scale instability threshold. The rupture time estimate obtained in closed form as a function of the relevant dimensionless groups is in striking agreement with the results of the numerical simulations of the original nonlinear evolution equations. This suggests that the weakly nonlinear theory adequately captures the underlying physics of the instability. When antagonistic (attractive/repulsive) molecular forces are considered, nonlinear saturation of the instability becomes possible. We show that the stability boundaries are determined by the van der Waals potential alone.

Journal Article↗