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Biomedical subjects

A M MANN

Publications and source records attributed to A M MANN.

6 recordsLinked to original sources
PubMed1963

TRANYLCYPROMINE CEPHALGIA.

Tranylcypromine, a useful antidepressant agent, has been linked with a clinical syndrome of undetermined incidence characterized by exceedingly severe and prolonged headache. Associated phenomena may include paroxysmal hypertension, pallor, chest pain and collapse. This violent reaction does not seem to be related to age, sex, duration of treatment, or pre-existing cardiovascular disease; nor is it possible to predict in whom it will occur. The clinical picture may sometimes be quite similar to that produced by subarachnoid hemorrhage or by pheochromocytoma. The mechanism of action is not known, although it is possible that the syndrome may be due to an amphetamine-like effect; i.e., that tranylcypromine influences the adrenergic component of the reticular activating system. The occurrence of severe headache in the course of tranylcypromine therapy is an indication for immediate withdrawal of the drug. Tranylcypromine cephalgia should be considered as part of the differential diagnosis of sudden, violent and prostrating headache.

Amphetamine↗
PubMed1963

THE PATHOPHYSIOLOGY OF DEPRESSION.

The conceptual difficulties in the diagnosis of depression, and the study of affect generally, hinder a clear approach to the "organic" side of depressive illness. While autonomic, biochemical and electrophysiological disturbances follow a general pattern in severe retarded depressions, correlation of these with the variable somatic symptomatology is only partial and demarcation from other psychiatric syndromes vague. Various attempts have been made to relate the patterns of autonomic reaction to thought content on the one hand and to central nervous system activity and organization on the other. In recent years, fragments of knowledge about physiological changes accompanying affective experiences in infancy have appeared. Isolated descriptions of what appears to have been the replacement of depression by somatic symptoms with or without somatic pathology have not yet been organized into a coherent whole. In this article the various studies and opinions relevant to the above conclusions have been reviewed and the findings discussed.

Depression↗