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Biomedical subjects

A M Macarthur

Publications and source records attributed to A M Macarthur.

8 recordsLinked to original sources
PubMed1977

Quinacrine in the management of malignant pleural effusion.

Twenty-five patients with malignant pleural effusion were treated with a single intrapleural dose of Quinacrine. Eighteen patients (72 per cent) had a significant response, with no reaccumulation of fluid for at least 2 months following treatment up to a maximum of 18 months in 2 patients. Seven patients (28 per cent) survived for longer than 1 year without evidence of recurrent effusion.

Breast Neoplasms↗
PubMed1977

Intracavity suction and drainage in the treatment of emphysematous bullae.

Patients with large intrapulmonary emphysematous bullae present a considerable therapeutic problem, particularly if their respiratory reserve is low, because of the risks of open operation. The method of draining intrapulmonary cavities, pioneered by Monaldi for the treatment of tuberculosis, is here described as applied to emphysematous bullae. Thirty-one patients were treated by intracavity suction and drainage. There were two operative deaths (6.5%). Apart from infection, no other significant postoperative complications ensued. Radiographic improvement occurred in all patients but one (96.7%). Where forced expiratory volume in one second and vital capacity were measured improvement was obtained in five out of six patients. Symptomatic improvement, which generally corresponded well to improvement in respiratory function tests, occurred in 28 patients (90.3%), all but one of whom survived.

Catheterization↗
PubMed1972

Distinction between infection and rejection in lung transplantation.

In distinguishing between infection and rejection after human lung transplantation clinical and radiological features were unhelpful, and even confusing. However, incipient rejection could be predicted and distinguished from infection by monitoring alterations in lymphocyte activity by the rosette inhibition test. Earlier prediction seems possible by detecting circulating lung-binding antibody. The ability to detect changes in the immunological status of a patient, even before clinical deterioration, has fundamental implications for the management of patients after transplantation.

Antigen-Antibody Reactions↗
PubMed1971

Lung transplantation in a patient with fibrosing alveolitis.

The transplantation of the right lung into a man aged 40 who was suffering from cryptogenic fibrosing alveolitis is described. Before transplantation he had been dependent on oxygen, even at rest, for 24 hours a day for almost two years. The donor was a boy of 16 years who had had a fatal cerebral haemorrhage. The transplanted lung functioned perfectly from the time of operation until the patient's sudden death two months later from an overwhelming haemoptysis apparently from a small peribronchial abscess rupturing into the pulmonary artery. By the third postoperative week the patient had been able to walk unaided and without distress outdoors. The problem of differentiating infection from incipient rejection is discussed. We conclude that clinically successful lung transplantation can be achieved, but only if the problems of lung function, infection, and immunosuppression can all be overcome.

Adult↗