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Biomedical subjects

A M Mancini

Publications and source records attributed to A M Mancini.

At least 73 records · Page 4Linked to original sources
PubMed1975

Acute and chronic effects of sulpride on serum prolactin and gonadotropin levels in castrated male rats (38581).

The effect of the acute or chronic administration of sulpiride on serum prolactin and gonadotropin levels was studied in castrated male rats. Sulpiride administered in acute intravenous injections induced a quick increase in serum prolactin levels and no significant changes in serum gonadotropins. The peak in serum prolactin was observed 30 min after the injection of sulpiride, with a decrease of serum prolactin levels at 60 and 120 min. The subcutaneous administration of sulpiride for 13 days induced a significant increase in serum prolactin levels at the end of the treatment, and no significant changes in serum FSH and LH levels.

Animals↗
PubMedDate not supplied

Progressive approach to the cytologic diagnosis of retroperitoneal spindle cell tumors.

OBJECTIVE: To assess the utility of fine needle aspiration biopsy (FNAB) in retroperitoneal spindle cell tumors with difficult tumor typing. STUDY DESIGN: Thirty-six cases of spindle cell tumors of the retroperitoneum were studied. Cytological diagnoses were set progressively: first exclusively by morphologic criteria on routinely stained slides, and then with the aid of immunocytochemistry (ICC), electron microscopy (EM) and clinical data. RESULTS: The morphologic diagnosis of benignity or malignancy was first made in double blind fashion by two researchers; it permitted an exact diagnosis in 31 cases (86%) by one examiner and 27 cases (75%) by the second. Using a progressive approach, benignity or malignancy was definitively determined in 35 cases (97%). As far as cytologic tumor typing is concerned, first it proved to be possible in 27 cases (75%) and then in 30 cases (83%) with the progressive approach. CONCLUSION: FNAB proved to be a useful tool in the diagnosis of retroperitoneal spindle cell tumors. A progressive approach to cytopathologic diagnosis, correlating morphology with ICC and EM results and matching them with clinical data, permitted a better differential diagnosis between benign and malignant spindle cell tumors and increased the possibility of correct tumor typing.

Adolescent↗