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Biomedical subjects

A M Manganaro

Publications and source records attributed to A M Manganaro.

At least 19 recordsLinked to original sources
PubMed1998

Benign keratotic squamous epithelial neoplasm of the palate: a unique lesion.

BACKGROUND: This case report describes a unique palatal tumor with features of a dermal neoplasm. Microscopically, the lesion appeared similar to a trichoepithelioma and trichoadenoma. METHODS: Light microscopic and immunohistochemical studies were performed to arrive at the final diagnosis. RESULTS: The lesion arose from the surface epithelium and had features of a dermal tumor. CONCLUSIONS: The case report describes a unique benign palatal neoplasm.

Adenoma, Pleomorphic↗
PubMed1997

Carcinoma arising in a dentigerous cyst with neck metastasis.

BACKGROUND: Squamous cell carcinoma arising in a dentigerous cyst is extremely uncommon. The diagnosis of carcinoma arising in a dentigerous cyst requires microscopically that an area of benign cystic epithelium is observed to transition into squamous cell carcinoma. In the present case, the patient was diagnosed with squamous cell carcinoma of the neck with an unknown primary. The primary site was found to be the follicular space associated with the right mandibular third molar. METHODS: Light microscopic studies were performed to arrive at the final diagnosis. RESULTS: Transition of the epithelial lining of the dentigerous cyst to squamous cell carcinoma was observed in multiple fields. CONCLUSIONS: The present case demonstrates that odontogenic cysts have to be considered a possible source of metastatic disease.

Aged↗
PubMed1997

Speech aid prosthesis for a patient with Wegener's granulomatosis: a clinical report.

A speech aid prosthesis was fabricated to correct the hypernasality of the speech of a patient. The hypernasality was caused by velopharyngeal insufficiency related to Wegener's granulomatosis. Speech aids have been used for cleft palate patients for whom surgical treatment was not indicated, surgical treatment was declined, or before surgical treatment as an evaluation for possible speech improvement. A speech aid prosthesis can be an important treatment modality when surgical correction of a velopharyngeal defect is not indicated.

Acrylic Resins↗
PubMed1997

Review of the transmucosal drug delivery.

The epithelial barriers limits the quantity of drug that can be delivered by a topical route for either local or systemic treatment. Any chemical that can help to reversibly minimize the epithelial barriers would improve drug uptake. Permeabilizers are such chemicals, and their mode of action generally involves fluidization of the intracellular lipid in the epithelial barrier. The vehicle in which the permeabilizers is delivered is equally important and needs to be specifically tailored to the solubility properties of the drug. Therefore, the selection of the appropriate permeabilizer and vehicle can make the delivery of medication across the oral mucosa a feasible option.

Absorption↗
PubMed1997

Review of the idiopathic bone cavity of the jaws.

The IBC is a lesion that favors the anterior portions of the jaws and occurs principally in young patients. The lesion radiographically tends to scallop up between the roots of the affected teeth and result in cortical expansion. The cause of the IBC has not been determined, but trauma seems least likely as the cause. The IBC is best treated by curettage, and follow-up is mandated. A biopsy is required to establish a definitive diagnosis and to rule out aggressive lesions that can appear radiographically similar to the IBC, such as the ameloblastoma and the parakeratinizing odontogenic keratocyst.

Adolescent↗
PubMed1996

The effects of permeabilizers on the in vitro penetration of propranolol through porcine buccal epithelium.

The purpose of the present study is to test the possibility that oleic acid might increase the permeability of buccal mucosa and thereby facilitate transmucosal drug delivery. Propranolol, a commonly used beta-blocking agent, was chosen as the model drug, and propylene glycol was chosen as a vehicle in which both propranolol and oleic acid are soluble. The flux of propranolol through porcine tissue mounted in perfusion chambers is monitored by ultraviolet spectroscopy. It is found that oleic acid in propylene glycol increases both the initial flux and the flux at steady state. With oleic acid concentrations in the range of 1 through 10%, there was a 3- to 4-fold increase in permeability to propranolol as judged by changes in permeability constant (KP) values. Oleic acid and propranolol also led to a virtual elimination of the lag time and a maximum drug flux exceeding that at steady state within 2 hours. Similar results were obtained with methyl oleate. Oleic acid has a cis double bond between carbons 9 and 10 in an 18-carbon chain, and it is thought that this double bond fluidizes membranes in the outer portion of the epithelium. This effect on membrane fluidity can account for the increase in KP. The effect of oleic acid in propylene glycol on the initial drug flux is mechanistically more complex and is though to be related to changing thermodynamic activity of the drug as water is displaced by propylene glycol in the tissue. Taken together, the present results indicate that permeability enhancement for the purpose of drug delivery through oral mucosa is feasible.

Animals↗
PubMed1995

Oral melanoma: case reports and review of the literature.

Oral melanomas occur most often on the palate and gingiva with the maxillary arch affected 80% of the time. Melanosis may exist many years before a definitive biopsy. Long-standing lesions may ulcerate but lack rolled borders or induration, features commonly associated with squamous cell carcinoma. Melanoma that involves oral mucosa is rare with an extremely poor prognosis. Surgical management remains the preferred treatment in combination with chemotherapy. Irradiation therapy is used occasionally as a primary modality in the elderly and medically compromised patients. Lymph node dissection is not routinely practiced. The poor prognosis of oral melanomas requires that pigmented lesions of undetermined origin be routinely biopsied.

Aged↗
PubMedDate not supplied

Erythema multiforme.

The diagnosis of erythema multiforme was established on the basis of physical examination, biopsy specimen evaluation, and the patient's medication history. Use of a triamcinolone mouthrinse and discontinuation of Triphasil-28 contraceptive led to resolution of the lesions.

Adult↗
PubMedDate not supplied

Periapical cemental dysplasia.

This case report shows the evolution of periapical cemental dysplasia (PCD) lesions over a 13-year period, and demonstrates that PCD lesions mature over time from purely radiolucent to radiopaque.

Adult↗
PubMedDate not supplied

Lingual osseous choristoma.

Osseous choristoma represents normal bony tissue in an abnormal location. A case report of a lingual osseous choristoma and a literature review are presented.

Child↗