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Biomedical subjects

A M Mangoud

Publications and source records attributed to A M Mangoud.

At least 19 recordsLinked to original sources
PubMed2000

Effect of parasite screening on refugee health.

Intestinal parasitic infections among refugees have been perceived as a public health problem for decades. A control program strategy to reduce morbidity and eventually transmission of intestinal parasites was initiated in 1993 by Mercy International (MI) for a group of Somalia refugee and has been implemented successfully. The management of the program operating within a comprehensive health care project and the control activities has been performed through the existing health facilities. This project was based on the "Comprehensive Health Care Approach" concept and applied to a collection of 10,000 Somali refugees. A project, which could be further, developed and modified for other similar situations. The strategy adopted was based on periodic chemotherapy of schoolchildren, intense health education in close collaboration with the local community leaders. An overall reduction in prevalence of intestinal parasitic infections of 53% was one of the targets achieved through this effort after three years of activities. 92% and 62% reduced the intensity of Ascaris lumbricoides and Trichuris trichiura infection, respectively. This approach in concert with the political commitment and limited operational costs is a warranty for the future sustainability of the control activities. Future control strategies are tailored to the results of evaluation surveys and are targeted to the identified high-risk areas. This project can be seen as a model in other refugee situation with the use of limited local resources.

Adult↗
PubMed1998

Modeling and forecasting monthly patient volume at a primary health care clinic using univariate time-series analysis.

Two univariate time-series analysis methods have been used to model and forecast the monthly patient volume at the family and community medicine primary health care clinic of King Faisal University, Al-Khobar, Saudi Arabia. Models were based on nine years of data and forecasts made for 2 years. The optimum ARIMA model selected is an autoregressive model of the fourth order operating on the data after differencing twice at the nonseasonal level and once at the seasonal level. It gives mean and maximum absolute percentage errors of 1.86 and 4.23%, respectively, over the forecasting interval. A much simpler method based on extrapolating the growth curve of the annual means of the patient volume using a polynomial fit gives the better figures of 0.55 and 1.17%, respectively. This is due to the fairly regular nature of the data and the lack of strong random components that require ARIMA processes for modeling.

Ambulatory Care↗
PubMed1998

The histopathological picture of the liver of hamsters experimentally infected with Leishmania D. infantum on top of Schistosoma mansoni infection.

No doubt, double and triple infection in a patient is not an uncommon phenomenon in the Old World. Consequently, the histopathological picture of the liver of Syrian golden hamsters experimentally infected with Leishmania. d. infantum on top of pre-infection with S. mansoni was studied. The results showed that the liver was markedly affected by the concomitant infection than infection with either parasite alone. The superadded Leishmania infection caused the early appearance of cell necrosis and fatty changes. The schistosomal granulomas were rounded in shape and well circumscribed. However, they were smaller in size and less in number when compared with schistosomal control. Also, there was a comparative decrease in the number of their cellular constitutions but without changing in the cell types. The schistosomal granulomas were surrounded with a rim of amastigotes laden macrophages. On the other hand, the leishmanial granulomas, were irregular in shape but comparatively increased in size and in number on the behalf of the schistosomal granulomas. Their cellular constitutions comparatively increased as well. So, it is concluded that the L.d. infantum infection on the top of S. mansoni infection suppressed the schistosomal pathological picture in the liver of hamsters.

Animals↗
PubMed1998

Renal changes in golden hamsters experimentally infected with Leishmania D. infantum on top of Schistosoma mansoni infection.

In Egypt, Schistosomiasis mansoni is one of the most important parasitic disease of man. Besides, in the last two decades, indigenous cases of infantile visceral leishmaniasis have been reported. These two parasites affect the kidney causing renal histopathological changes. Thus, it was aimed to study the concomitant infection of L. d. infantum on top of S. mansoni infection in Syrian golden hamsters, the model animal for both parasites. The results showed that the renal changes were more or less the same as infection with either parasite alone. Both parasites produce mesangial cell proliferation and mesangial matrix increase. Some glomeruli showed complete replacement of the capillary tuft with structureless homogenous material. In one S. mansoni positive control hamster Schistosoma eggs were seen within granulomas and atrophic glomeruli. However, the lesihmanial infection, more or less suppressed the schistosomal infection. The leishmanial infection itself became more prominent and the renal changes it caused appeared earlier and were more obvious.

Animals↗
PubMed1998

The histopathology of the intestine in hamsters infected with Leishmania D. infantum on top of pre-existing schistosomiasis mansoni.

In general, both Schistosoma mansoni and Leishmania, d. infantum affect more or less the same human organs. While the liver is the main organ affected, the intestine follows in importance. In the present study, L.d. infantum on tip of pre-existing S. mansoni in Syrian golden hamsters had delayed the appearance of both schistosomal and leishmanial granulomas in the intestine the positive control with either parasite alone. However, the leishmanial infection suppressed the schistosomal infection. Nevertheless, both types of granulomas caused shortening and broadening of the intestinal villi. The concomitant infection with leishmaniasis infantum and schistosomiasis mansoni promote the development of many pathological changes (liver, kidneys, intestine, blood picture etc.). No doubt, these changes lead to marked changes in the typical clinical picture of both parasites. Consequently, parasitological diagnosis of visceral leishmaniasis in concomitant infection is a must as in a case of VL. and HIV.

Animals↗
PubMed1998

The pathology of the heart and lung in Syrian golden hamsters experimentally infected with Leishmania d. infantum on top of pre-existing Schistosoma mansoni infection.

No doubt, double and triple infections are not uncommon features in some of the developing countries. In this paper, the effect of leishmanial infantum and schistosomal mansoni infection on the heart and lung of hamsters promoted many changes not seen in positive control with either parasite alone. Of these important changes, were the presence of leishmanial cardiac granulomas and earlier pulmonary granulomas in the lung were more or less the same as in positive schistosomal control. No doubt, with pulmonary schistosomiasis mansoni dangerous disease. Moreover, additional infection with pulmonary leishmaniasis increases the dramatic clinico-pathological picture.

Animals↗
PubMed1997

Modeling obesity using abductive networks.

This paper investigates the use of abductive-network machine learning for modeling and predicting outcome parameters in terms of input parameters in medical survey data. Here we consider modeling obesity as represented by the waist-to-hip ratio (WHR) risk factor to investigate the influence of various parameters. The same approach would be useful in predicting values of clinical parameters that are difficult or expensive to measure from others that are more readily available. The AIM abductive network machine learning tool was used to model the WHR from 13 other health parameters. Survey data were collected for a randomly selected sample of 1100 persons aged 20 yr and over attending nine primary health care centers at Al-Khobar, Saudi Arabia. Models were synthesized by training on a randomly selected set of 800 cases, using both continuous and categorical representations of the parameters, and evaluated by predicting the WHR value for the remaining 300 cases. Models for WHR as a continuous variable predict the actual values within an error of 7.5% at the 90% confidence limits. Categorical models predict the correct logical value of WHR with an error in only 2 of the 300 evaluation cases. Analytical relationships derived from simple categorical models explain global observations on the total survey population to an accuracy as high as 99%. Simple continuous models represented as analytical functions highlight global relationships and trends. Results confirm the strong correlation between WHR and diastolic blood pressure, cholesterol level, and family history of obesity. Compared to other statistical and neural network approaches, AIM abductive networks provide faster and more automated model synthesis. A review is given of other areas where the proposed modeling approach can be useful in clinical practice.

Adult↗
PubMed1997

Immunological pattern in Syrian golden hamsters experimentally infected with Schistosoma mansoni and Leishmania d. infantum.

The immunoglobulins (IgG, IgM, IgE, & IgA) and the complements (C3 & C4) were studied in hamsters as result of a single infection (S. mansoni or L.d. infantum) and as concomitant infection (L.d. infantum on top of S. mansoni). The immunological pattern showed profound IgG and IgA increase in the concomitant group than either infection alone. Also, concomitant infection induced more IgE increase than either infection alone. On the other hand, C3 and C4 showed more decrease in concomitant infection. The whole results were discussed.

Animals↗
PubMed1997

Histopathological studies on detrusor muscle in schistosomiasis haematobium patients with poor bladder contractility.

The electron microscopic structure of the detrusor muscle in schistosomiasis patients with poor bladder contractility as evaluated by urodynamic measures had been compared with normal detrusor muscle from non-schistosomiasis patients. In the patients with poor bladder contractility the detrusor was formed of muscle fibers which were smaller in size, widely separated by collagen and showed degenerative changes and hyalinosis. No evidence of smooth muscle hyperplasia, mitosis or fibroblastic proliferation was seen. This pathological changes in the bladder of schistosomiasis patients may explain the cause of poor contractility.

Animals↗
PubMed1997

Histopathological studies of Syrian golden hamsters experimentally infected with Leishmania D. infantum.

In the 1980s, infantile visceral leishmaniasis was documented in Al Agamy (Alexandria). The causative agent is Leishmania d. infantum and the insect vector is Phlebotomus langeroni. In this paper, Syrian golden hamsters were chosen as a model animal for histopathological studies of L. d. infantum. Twenty four male hamsters were experimentally infected with L.d. infantum. Every week, two hamsters were sacrificed and parts from the liver, heart, lung, spleen, small intestine and kidney were paraffin sectioned and stained with haematoxylin and eosin or with Giemsa stain. The leishmanial granuloma was the main histopathological changes and the liver was the main organ affected. Leishmanial granulomas were common in the liver, but few in lung and small intestine. The hepatic granulomas increased in surface areas and in number in the late stage of the infection (< 6 weeks). They were formed mainly of histiocytes, less lymphocytes and very few eosinophils with necrosis inside and bridging in between granulomas mainly occurred in the late stage of infection. Neither fibrosis nor peripheral delimitation was seen. Kupffer cell hyperplasia was seen throughout the experimental period (12 weeks). The spleen showed expansion of the red pulp and atrophy of the white pulp. The kidney showed mesangial cell proliferation and the mesangial matrix increased accompanied with amyloid deposition. All the tissue sections were photographed and the results were discussed.

Animals↗
PubMed1996

A village seizes the reins of health care.

The setting-based approach to health promotion and education has been adopted in an Albanian village. The project requires a high degree of self-determination and self-help. External support comes from the International Islamic Relief Organization. Encouraging progress is being made as villagers acquire a wide range of skills, connected not only with the provision of care but also with such matters as fund-raising, health education and relations with public and private bodies.

Albania↗
PubMed1996

P 53 suppressor gene and cathepsin D expression in correlation with cellular and humoral immunity in cutaneous leishmaniasis.

A total of fifteen clinically and parasitologically proven adult cases of cutaneous leishmaniasis were studied for the demonstration of premalignant factor(s). The levels of antibodies against Leishmania parasite were measured with the indirect haemagglutination test (IHAT) and evaluated with the results of lymphoblast transformation test (LTT), a tumour suppressor gene (P53) and an asportic proteinase enzyme (Cathepsin D). Three patients (females) refused to be biopsied. The results showed a direct correlation between elevation of IHAT in 7/12 patients (Titers 1/128 to 1/512) and elevation of LTT in 7/12 patients (82 to 90%). On the other hand, two males with low (?) seropositive IHAT (1/64) and low LTT (20 & 40%) gave positive P53 antibody and moderate (1) and marked (1) degrees Cathepsin D. So, it is concluded that cutaneous leishmaniasis infection particularly chronic one favours the premalignant changes in the granulomatous lesions.

Animals↗
PubMed1996

Abductive machine learning for modeling and predicting the educational score in school health surveys.

The use of modern abductive machine learning techniques is described for modeling and predicting outcome parameters in terms of input parameters in medical survey data. The AIM (Abductory Induction Mechanism) abductive network machine-learning tool is used to model the educational score in a health survey of 2,720 Albanian primary school children. Data included the child's age, gender, vision, nourishment, parasite infection, family size, parents' education, and educational score. Models synthesized by training on just 100 cases predict the educational score output for the remaining 2,620 cases with 100% accuracy. Simple models represented as analytical functions highlight global relationships and trends in the survey population. Models generated are quite robust, with no change in the basic model structure for a 10-fold increase in the size of the training set. Compared to other statistical and neural network approaches, AIM provides faster and highly automated model synthesis, requiring little or no user intervention.

Achievement↗
PubMed1993

Hydrocele in filarial and non filarial patients. Histopathological, histochemical and ultrastructural studies.

Twenty biopsied material of the testicular tissue were obtained from patients with unilateral hydrocele (eight due to lymphatic filariasis and twelve of idiopathic causes). Twenty biopsies lymphatic were also obtained from the normal unaffected testes and were used as control. The data obtained from histopathological, histochemical and ultrastructural studies revealed alternation in the testicular tissue with hydrocele than in the normal control testis. In the filarial hydrocele 37.5% of the cases showed thickening of the basement membrane and fibrosis with arrest of the spermatogenesis at the level of secondary spermatocytes. In addition, 12.5% showed thickening with interstitial fibrosis. Microfilariae were seen in hydrocele fluid of 3/8 cases (37.5%). In the idiopathic hydrocele 50% of the testicular tissue showed marked collagen deposits and testicular atrophy with fibrosis and thickening of basement membrane. The second 50% of cases showed variable degree of maturation arrests. Explanation for these variations in the pathological and anatomical pictures in both types of hydrocele is suggested. In the filariasis hydrocele it is due to the inflammatory response that may subside and recurrent. In the idiopathic hydrocele, it is due to the irreversible hypoxia caused by the continuous mechanical pressure due to huge amount of hydrocele fluid resulting in irreversible degenerative process with marked fibrosis.

Adult↗
PubMed1992

Tumor necrosis factor (TNF alpha) in lymphadenopathy and bone marrow involvement: histopathological and serological study.

Serum samples were collected from 40 patients with enlarged lymph nodes. Lymph node and bone marrow biopsies were performed and processed as usual. Tumor necrosis factor-alpha (TNF alpha) was determined in the sera by factor test human TNF alpha ELISA kit. Histopathological studies of lymph node and bone marrow biopsies were evaluated. The data obtained from this study showed that bone marrow was involved in only 5 patients and their TNF showed the lowest level in this study with a mean level 50 pg/ml. The highest level of TNF occurred in cases with granulomatous lymphadenitis (124 pg/ml) followed by reactive lymphadenitis (105 pg/ml). It can be considered that TNF reflects the immune status of the patient and its study in the serum can be of help in evaluating the progress of the disease. An extended study is need to evaluate the role of TNF-alpha as a prognostic marker in malignancy.

Adolescent↗
PubMed1992

An acute case of infantile visceral leishmaniasis histopathological and histochemical studies.

Some histopathological and histochemical studies were carried out on the intestines of an acute case of infantile visceral leishmaniasis. Macrophages-carrying amastigotes were seen mainly in the villous tips, mucin secretion inside the mucosal cells was mild, deposits of collagen and fibrin in the lamina propria were marked and the argentaffin cells were partially lost. The whole results were discussed.

Acute Disease↗
PubMed1992

Histopathological and histochemical studies on the sigmoidal and rectal tissues of hepatosplenic children with gastro-intestinal troubles.

Hepatosplenomegaly accompanied with different intestinal troubles is more or less a marked clinical manifestations in children. The histopathological and histochemical changes were studied in biopsied materials taken from the sigmoidal and rectal tissues of 49 children. These children had schistosomiasis mansoni (26), schistosomiasis and amoebiasis (4), schistosomiasis and tuberculosis (TB.) (2), amoebiasis (4), thalassemia (6), acute myeloid leukaemia (AML) (1), mucopolysaccharidosis (1) and bacillary dysentery (5). The pathological changes were erosion ulceration hyperplasia, atrophy, crypt-abscess and fibrosis (mucosa) and oedema, congestion, cellular infiltration (Lamina propria). The chemical changes were the mucin secretion, deposition of collagen and fibrin and activity of the argentaffin cells. Not all the disease agent had the same effect, but changes were marked mainly in children with S. mansoni and/or E. histolytica.

Child↗