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Biomedical subjects

A M Marques

Publications and source records attributed to A M Marques.

15 recordsLinked to original sources
PubMed1998

[Adjuvant therapy with a glycoprotein IIb-IIa inhibitor (abciximab) in coronary angioplasties with a high thrombotic risk].

INTRODUCTION: We retrospectively studied our experience with adjunctive therapy with glycoprotein IIb-IIIa inhibitor (abciximab) on patients with a high risk of thrombotic complications during coronary angioplasty (PTCA). PATIENTS AND METHODS: From September 1996 to November 1997, we performed PTCA in 210 patients, and abciximab was given to 38 (18%) of them. The interventions were urgent (primary PTCA in acute myocardial infarction) in 55% of the cases. The mean age of patients was 68.6 +/- 12 years and 71% were male. The reasons for coronary intervention were: acute myocardial infarction in 21 patients (55.3%), unstable angina in 9 (23.7%) and stable angina in 8 (21%). Coronary stents were implanted in 13 patients (34%) and an intra aortic balloon pump was used in 4 (11%). The reasons for using abciximab were: thrombus containing lesion: 22 (57.9%); other type B2/C lesion characteristics: 6 (15.9%); acute closure post balloon PTCA: 9 (23.7%), sub-acute stent thrombosis: 1 (2.6%). Oral acetilsalicilic acid and intravenous heparin were given to all patients at the beginning of the intervention. The mean APTT was 124 +/- 32 seconds at the end of the procedure. RESULTS: The arterial sheaths (8 French) were removed six hours after procedure, according to the normalisation of APTT values. Angiographic success in this group of patients was 100%. One patient died during hospitalisation due to left ventricular failure. There was no need for repeated angioplasty or coronary bypass grafting during hospital stay. The main complications related to the use of abciximab were: bleeding (requiring transfusion) in four patients 10.5%); severe thrombocytopenia (< 50,000 platelets/mm3): 1 (2.6%): cardiac tamponade (requiring pericardiocentesis): 1 (2.6%) and pseudo-aneurysm of femoral artery (requiring vascular surgery): 1 (2.6%). CONCLUSIONS: The use of abciximab as adjunctive therapy in this small group of patients undergoing coronary interventions with high risk of thrombotic complications is associated with high procedural success, but at the expense of high rates of bleeding complications. Therefore, special care must be applied during and after the procedure to enhance the safety of the patients treated with this drug.

Abciximab↗
PubMed1996

[Traumatic aortic valve insufficiency].

The traumatic aortic valvular insufficiency (TAVI), through less frequent after a non-penetrating thoracic traumatism, is a serious entity with a very reserved prognosis. So it must be suspected in every patients with signs or symptoms of de novo heart failure post-traumatism. The transthoracic echocardiography and eventually transesophageal echocardiography have a fundamental role in the confirmation of the diagnosis. The clinical picture of traumatic aortic regurgitation is quickly evolutionary and the non efficacy of medical therapy has placed the valvular substitution surgery as the best succeeded treatment. With the advent of the aortic valve repairing surgery some TAVI cases has been submitted to this procedure. Nevertheless, the development of residual aortic regurgitation in these situations, usually requiring later valvular replacement surgery, make the aortic valvuloplasty a controversial surgical technique. The AA describe a recent clinical case of aortic regurgitation after a non-penetrant thoracic traumatism, discussing the aspects connected with physiopathology, diagnosis and therapy. The singularity of this case was based on the fact that the initial clinical diagnosis had been prejudiced by the context of a polytraumatism and there had been a time free of symptoms between the traumatism and the beginning of the symptomatology of left ventricular failure. Even though the identification of the problem allowed an intensive treatment of this serious situation that ended with the replacement of the aortic valve by mechanical aortic prosthesis, with the patient's total recovery.

Accidents, Traffic↗
PubMed1994

[Pacemaker implantation in a patient with persistent left superior vena cava and atresia of the right superior vena cava].

Persistent left superior vena cava with absence or atresia of right superior vena cava is a congenital abnormality of systemic venous return to the heart which may complicate the insertion of a pacemaker electrode. We present a case report of a patient with conduction system disturbances in whom this abnormality was diagnosed during pacemaker implantation, with the possibility of using a transvenous electrode without active fixation system.

Aged↗
PubMed1993

[Primary tricuspid valve insufficiency. Report of 2 clinical cases].

Two case reports of primary tricuspid regurgitation are presented which diagnoses were made in mean adult life after a long period of few symptoms. The clinical outcome of the two cases was uneven in the sense that only one of them could be corrected with single surgical procedures. Despite relatively rare, this pathology could probably be turned more frequent with a complete and systematic echocardiographic approach. In connection with the reported cases, a review is made of the main etiologies and of some published reports.

Humans↗
PubMed1991

[Myocardial infarct in a young man with normal coronary vessels: apropos of a clinical case treated with streptokinase].

The authors report a case of a 31 year old young man who suffered acute myocardial infarction and was subjected to early treatment with streptokinase. The immediate follow-up showed a complete recanalization of the infarct-related vessel, without any identifiable obstructive lesion on coronary arteriography. Related to this angiographic finding, common in myocardial infarction in the young adult, the authors debate the implicated mechanisms, focusing essentially in the relation endothelium-platelets-vasomotricity. The issue of cigarette smoking as a risk factor and its possible pathogenic implication, even in the absence of atherosclerotic plaque, is also approached.

Adult↗
PubMedDate not supplied

Personal computer software evaluation in interactive generation of pig liver three-dimensional anatomical images.

The efficiency of software for a personal computer in the interactive generation of three-dimensional (3D) images from computer tomography was studied in six pig livers after hepatic resection and catheterization of the hepatic and portal veins. After perfusion the livers were submitted to computed tomography angiography, volumetric measurement by water displacement, and production of an acrylic model of the veins by the injection and corrosion method, by which the lengths of the hepatic and portal veins were measured. From the angiogram, the software generated a 3D image that allowed measurement of the vein lengths. The identified branches of the hepatic and portal veins were correlated with the hepatic sectors and segments, respectively. The virtual measures from the 3D images were compared with the real measures. There were no significant differences between the topography and the vessel length. The mean difference between the volumes calculated from software and those measured by water displacement corresponded to 1.2%, and between the vessel lengths, 0.2%. In conclusion, the software for personal computer (named LIVER3D) is efficient, allowing interactive inspection of 3D images. All virtual measurements of liver vessel length and partial/total liver volume were similar to the actual ones.

Animals↗
PubMedDate not supplied

[Main left coronary artery disease. Aspects of its diagnosis and treatment].

The Left Main Disease (LMD) assumes a special particularity within the coronary pathology, because of its seriousness and of its urgent need of surgical treatment. The lesion is associated mainly with clinical situations of unstable angina, and who's diagnose by non-invasive methods is extremely difficult; among these methods the echocardiography and specially the stress test still remain of most value in this diagnosis. Coronary arteriography remains the standard exam and is indispensable for a positive confirmation of diagnosis. However, the risk involved here is significantly higher than in other coronary pathologies especially if the lesion of LMD is localized in the proximal region or is ostium level. Therefore, in this review, the need of special care is emphasized before, during and after catheterization, in patients with sunpect of LMD or in those in which the diagnosis was placed during the angiographic examination. Finally, it is very important to recognize the most dangerous situations in order to rightly identify those who need urgent surgical treatment.

Catheterization↗