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A M Mejía-Domínguez

Publications and source records attributed to A M Mejía-Domínguez.

7 recordsLinked to original sources
PubMed1998

Epidemiology of lymphomas in children residing in Mexico City.

BACKGROUND: The aim of this paper is to present the epidemiological characteristics of time, subject and place of lymphomas in children residing in Mexico City, Mexico (MC). METHODS: The type of study was a retrospective hospital survey. All records of children with lymphomas registered between 1982 and 1991 at the main hospitals that treat children with cancer in MC were reviewed. Neoplasms were classified into Hodgkin's disease (HD) and non-Hodgkin's lymphomas (NonHL). Trend and incidence by sex, age and area of residence in MC were evaluated. Time of diagnosis, as well as parental occupation and educational level, were registered. RESULTS: A trend was only observed for HD in the total group (r:0.62; P = 0.05). In 1991, incidence for HD was 6.12 (rates x 10(6)) and 3.87 for NonHL. The highest average incidence was found in children 5-9 years of age (5.40) for HD, and in the age groups of 1-4 and 5-9 (3.10 and 3.33, respectively), for NonHL. Incidence was higher among boys for both lymphoma categories, but the male-to-female ratio was much higher in HD. Time of diagnosis, incidence in terms of place of residence, and parental educational level and occupation also differed from one lymphoma category to the other. CONCLUSION: The epidemiology of HD is different from that of NonHL, both showing a pattern similar to that of Latin American children.

Child↗
PubMed1990

[Chronic gastric ulcer in a child with Glanzmann thrombasthenia. Usefulness of prostaglandin E2].

Gastric ulcers in children are often seen as a result of an imbalance between nocive factors and the resistance of the mucosa. Glanzmann's thromboastenia is a defect in platelet aggregation and its nature may be associated to local factors which precipitate or perpetuate bleeding. Prostaglandins are hormones of local action which inhibit the secretion of acid and therefore protect the mucosa. We report a case of an 18 year old male youngster with Glanzmann's thromboastenia and a gastric ulcer previously unsuccessfully treated with cimetidine, aluminum hydroxide solution, ranitidine, sucralfate and later controlled with PGE2. In sum, the usefulness of the cytoprotecting effects of the prostaglandins are successfully evaluated in a young man with platelet aggregation abnormalities.

Adolescent↗
PubMed1989

[Long-term clinical course of patients with chronic autoimmune thrombocytopenic purpura].

We studied 296 patients with thrombocytopenic purpura in our hospital from 1974 to 1985; 179 acute and 117 chronic forms. We identificated inherence forms (9.5%), of the last 106, 73 accepted to participate in the long time study. We found 69 patients with autoimmune chronic thrombocytopenic purpura, with the following response to the treatment with prednisone: 1. Long total remission for 8 to 100 months in 27 patients. 2. Total remission with relapse in 35 patients. 3. Partial remission in 5 patients. 4. No remission in 2 patients. We realized splenectomy in 16 patients of second group, in four of third group and one of fourth group. Everybody are in total remission althrough we had two with temporal relapse. We analyzed the factors with the excellent evolution, 5 of 69 patients with autoimmune forms (7.2%), their evolution to disseminated eritematous lupus. Nobody of the cases evolutioned to malignance.

Adolescent↗
PubMedDate not supplied

Malnutrition in childhood lymphoblastic leukemia: a predictor of early mortality during the induction-to-remission phase of the treatment.

BACKGROUND: Previous reports have shown that undernourished children with acute lymphoblastic leukemia (ALL) have a poorer long-term survival as compared with children with normal nourishment status. It has been shown that both the relapse and mortality rates of undernourished children with ALL are higher during the continuation phase of the chemotherapy and are apparently related to a poor tolerance of ablative chemotherapy. No previous articles have analyzed the early mortality rate of these patients. METHODS: We carried out a case-control study, and have studied the effect of severe malnutrition on the mortality of 17 children with ALL during the initial induction-to-remission phase of the treatment. These 17 cases were compared with 76 controls who had survived at least the phases of induction and consolidation. RESULTS: It was found that the chance of dying during the initial phase of the treatment was 2.6 times higher (confidence interval 95%: 0.55-11.89) in undernourished children with ALL than in those children with normal nourishment status. The risk of death increased with the severity of undernourishment (p = 0.04). CONCLUSIONS: These data confirm the prognostic value of malnutrition in children with ALL and suggest that undernourishment may also influence early mortality during the induction-to-remission phase of the treatment.

Adolescent↗