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Biomedical subjects

A M Melikian

Publications and source records attributed to A M Melikian.

17 recordsLinked to original sources
PubMed2000

[Continuous ambulatory peritoneal dialysis in patients with diabetes mellitus].

AIM: To analyse the results of continuous ambulatory peritoneal dialysis (CAPD) in diabetes mellitus (DM) patients, to specify complications, to evaluate transport characteristics of peritoneal membrane. MATERIAL AND METHODS: The ability of peritoneal membrane to eliminate low-molecular substances (creatinine, urea), electrolytes and to evaluate treatment efficacy by residual renal function (peritoneal equilibration, total urine and creatinine clearance). RESULTS: DM patients on CAPD developed vascular complications typical for DM:gangrene (n = 2), diabetic foot (n = 4), acute disorder of cerebral circulation (n = 3), acute myocardial infarction (n = 3). Diabetics' residual renal function deteriorated faster than in patients with non-diabetic uremia, though transport characteristics of the peritoneum in diabetics and non-diabetics were the same. Peritonitis in diabetics was observed much less frequently than in non-diabetics. CONCLUSION: CAPD is an adequate replacement therapy in patients with uremia of different origin including diabetes. In the course of the treatment DM patients develop complications typical for basic disease but their frequency is unrelated to CAPD.

Biological Transport↗
PubMed1982

[Circulatory failure in chronic glomerulo- and pyelonephritis].

The frequency and degree of circulatory insufficiency depending on the stage of the disease are analyzed in 404 patients with chronic glomerulonephritis and 145 patients with chronic pyelonephritis aged 15 to 74 years. When the renal function is still preserved different degrees of circulatory insufficiency are diagnosed in 29.4% of patients. Circulatory insufficiency complicates more often chronic glomerulonephritis than pyelonephritis and is more common in the aged. Latent cardiac insufficiency is more common. In the period of chronic renal insufficiency cardiac decompensation is seen in 78.1% of cases, its frequency is practically the same in glomerulonephritis and pyelonephritis. The mechanisms of development of cardiac insufficiency and the principles of treatment depending on the functional state of the kidneys are discussed.

Adolescent↗
PubMed1978

[Possibility of using enriched glial and neuronal cell fractions to study transport of neurotransmitter amino acids in old age].

Calculated on a protein basis the yield of neuronal and glial cell-enriched fractions obtained from the brain of aged and adult rats was found to be equal. In aged animals the high affinity uptake of 14C-GABA by neuronal fractions is reduced by 27.34% while that of glial fractions by 11.87%. At 0 degrees both age groups studied the uptake of 14C-GABA is greatly inhibited--by 66% in neurones and 92% in glia. The conclusion is drawn that glial cells are changed much less with age than neurones and thus their role as modulators of neuronal function increases with age.

Aging↗
PubMedDate not supplied

[Mechanical properties of intercellular contacts of small intestinal epithelium].

It has been shown that when long-acting forces are applied, the intercellular contacts in the small intestine epithelium are destroyed at the values of these forces lower than the adhesion ones obtained at the application of short-term loads. Starting with some threshold value of the load viscose-elastic properties of intercellular contacts are shown up. Thus the threshold varies essentially for different cells of the population: 4 variations are observed. A removal of bivalent cations from the tissue significantly decreases the threshold value of the forces and decreases the viscosity while the excessive concentrations of bivalent cations increase the threshold value of forces, the membrane viscosity and contact components.

Animals↗