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Biomedical subjects

A M Mendes

Publications and source records attributed to A M Mendes.

4 recordsLinked to original sources
PubMed1985

Effects of cortisol and progesterone on insulin binding and lipogenesis in adipocytes from normal and diabetic rats.

Cortisol implants in normal and diabetic rats reduced body weight, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in isolated adipocytes, whilst insulin sensitivity was unchanged. In normal but not diabetic rats these changes were accompanied by increased serum glucose and insulin concentrations. In contrast, progesterone implants in normal and diabetic rats increased body weight gain, adiposity, insulin receptor concentration and both basal and insulin-stimulated rates of lipogenesis in adipose tissue, again without affecting insulin sensitivity. Progesterone did not affect serum insulin concentrations in normal or diabetic rats but accelerated the decline in serum glucose concentrations which occurred during an overnight fast in diabetic rats. The results suggest that cortisol inhibits lipogenesis in adipose tissue without affecting insulin sensitivity, cortisol reduces insulin binding in adipose tissue without a requirement for hyperinsulinaemia, which might itself indirectly lead to down-regulation of the insulin receptor, and in diabetic rats progesterone stimulates lipogenesis in adipose tissue without any increase in food intake or serum insulin concentrations suggesting that progesterone may have a direct anabolic role in adipose tissue.

Adipose Tissue↗
PubMedDate not supplied

[Nurses dealing with emergency patients: a psychodynamic approach].

The purpose of this research is to investigate the existence of defensive strategies employed by intensive care unit nurses at a public hospital in Brasilia-DF, manage the suffering generated in the nurse-patient relationship, which arises a constant confrontation with life-death contents. This effort involved four collective interviews with eight professionals. The interviews theme were the difficulties, limitations and fulfillment with the patient care. The defensive behavior were analysed through the professionals' speeches. Four strategies were identified: impersonalness, emotional distance, avoidance of communication and high evaluation of technical procedures. The employment of these strategies facilitates a psychological balance to minimize the contact with suffering, although, these defensive strategies can affect quality of work or the nurse's life extra work.

Adult↗