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Biomedical subjects

A M Minford

Publications and source records attributed to A M Minford.

11 recordsLinked to original sources
PubMed1996

Treatment of homozygous protein C deficiency with subcutaneous protein C concentrate.

Subcutaneous protein C concentrate (Immuno, Vienna) was used to treat a child with homozygous protein C deficiency who was formerly treated with intravenous protein C concentrate. After 3000 units subcutaneous protein C concentrate (250 iu/kg), protective protein C levels were maintained for 48 h after infusion, with peak levels at 12 h. Subcutaneous protein C concentrate is given every third day and is well tolerated by the patient. No thrombotic events have occurred. We conclude that subcutaneous administration of protein C concentrate is a valuable therapeutic option in the long-term management of homozygous protein C deficiency and avoids the potential hazards of long-term central venous lines.

Female↗
PubMed1993

Campomelic dysplasia: evidence of autosomal dominant inheritance.

We present a mother and daughter with clinical and radiological findings consistent with the diagnosis of campomelic dysplasia. Milder tibial bowing and significant shortening of the phalangeal bones of both hands and feet may distinguish this from the classical autosomal recessive form of the disease.

Bone Diseases, Developmental↗
PubMed1992

Computed tomography findings in partial seizures.

The computed tomography findings in 82 children with partial seizures of unknown aetiology were reviewed. All had seizures with predominantly focal motor phenomena and none had abnormality on neurological examination. Findings on computed tomography were normal in 64 children (78%) and abnormal in 18 children (22%). Fourteen children had changes representing static pathology (mainly cerebral atrophy) which did not influence patient management but four had potentially correctable lesions (two tumours and two arteriovenous malformations). There were no correlations between seizure control, seizure duration, intellectual handicap, postictal weakness, electroencephalographic findings, and abnormality on the computed tomogram. In particular, none of these features were useful in predicting the presence of a tumour or arteriovenous malformation. It is concluded that a computed tomogram is indicated in every child with partial seizures.

Adolescent↗
PubMed1982

Food intolerance and food allergy in children: a review of 68 cases.

The clinical and laboratory features of 68 children with food intolerance or food allergy are reviewed. Young children were affected the most with 79% first experiencing symptoms before age 1 year. Forty-eight (70%) children presented with gastrointestinal symptoms (vomiting, diarrhoea, colic, abdominal pain, failure to thrive), 16 (24%) children with skin manifestations (eczema, urticaria, angioneurotic oedema, other rashes), and 4 (6%) children with wheeze. Twenty-one children had failed to thrive before diagnosis. A single food (most commonly cows' milk) was concerned in 28 (41%) cases. Forty (59%) children had multiple food intolerance or allergy; eggs, cows' milk, and wheat were the most common. Diagnosis was based on observing the effect of food withdrawal and of subsequent rechallenge. In many children food withdrawal will mean the use of an elimination diet which requires careful supervision by a dietician. Laboratory investigations were often unhelpful in suggesting or confirming the diagnosis.

Animals↗
PubMed1981

Engelmann's disease and the effect of corticosteroids. A case report.

A 13-year-old girl presented with a two-year history of pain in the right thigh and right forearm. Engelmann's disease was diagnosed on the basis of radiological appearances and histological examination of the bone. Her symptoms subsided after biopsy of the bone, but two weeks later she developed severe pain in the left tibia and was unable to walk. Radiological features of Engelmann's disease were found in the left tibia and other long bones although these bones had been radiologically normal one month previously. Treatment with prednisolone gave rapid relief of pain and allowed the patient to become mobile again. Four months later the radiological appearances showed significant improvement. The use of corticosteroids in this disorder is discussed.

Adolescent↗
PubMed1980

Prostaglandin synthetase inhibitor in an infant with congenital chloride diarrhoea.

Hyper-reninaemia, hypokaluria, and hypokalaemia in an infant with congenital chloride diarrhoea improved during treatment with a prostaglandin synthetase inhibitor, ketoprofen. There was evidence of increased activity of therenin-aldosterone system when ketoprofen was stopped. It is suggested that prostaglandins may be involved in stimulating the renin-aldosterone system in congenital chloride diarrhoea.

Chlorides↗
PubMed1979

Haemorrhage responsive to vitamin K in a 6-week-old infant.

A 6-week-old breast-fed infant presented with vomiting, jaundice, and irritability. Haemorrhage occurred after lumbar puncture, and a coagulation abnormality which responded to vitamin K was found. It would seem prudent to estimate the prothrombin time before invasive procedures in breast-fed infants of this age, or to give vitamin K to such infants when doubt exists about previous vitamin K administration.

Humans↗
PubMedDate not supplied

Asymmetry of gait in normal children demonstrated by polarized light goniometry.

Polarized light goniometry recordings were obtained from 46 neurologically normal children aged 4--15 years. Asymmetry in terms of thigh and knee angle differences between right and left legs was common in children aged less than 10 years but uncommon in children aged more than 10 years. This asymmetry was predominantly in the direction of more flexion on the right side. The tendency for goniometric asymmetry to mirror asymmetry on clinical examination was slight and did not reach statistical significance. It is suggested that angular asymmetry during gait which occurs in some children under 10 years of age may be related to unequal rates of maturation of the two hemispheres. Other minor neurological asymmetries, neuro-anatomical asymmetries nd postural asymmetries which may be found in normal children are discussed.

Adolescent↗