Vulvar melanosis and lentiginosis: a case report.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to A M Mroueh.
Explore the source record for details and available documents.
Transmural flux of alanine across the vaginal epithelium of the rabbit is a specialized mechanism. There is a net serosal to mucosal translocation of the amino acid in the absence of a concentration gradient. Changes in reproductive cycle do not influence this mechanism but, in castrated animals, it is abolished. Transport properties of vaginal epithelium is important because of increasing utilization of intravaginal contraceptives.
Of 28 patients presenting with amenorrhea-galactorrhea, pituitary tumors were confirmed in eight. Six patients had occult hypothyroidism and the rest had an endocrine profile suggestive of pituitary tumor or of an idiopathic etiology. Treatment with bromocryptine resulted in suppression of the inappropriate lactation and restoration of regular menstrual function. In five cases, however, the galactorrhea was only diminished and in four of these cases, normal ovarian function did not return. Of the 19 patients that were seeking fertility and continued the medication for at least 20 days, nine pregnancies resulted. A similar response to bromocryptine was observed regardless of the underlying cause of the amenorrhea-galactorrhea.
Explore the source record for details and available documents.
In ten patients with amenorrhea-galactorrhea who had hyperprolactinemia, ovulation could not be induced clomiphene citrate or exogenous gonadotropins. Treatment with bromocryptine in eight of these patients resulted in suppression of PRL in all, cessation of galactorrhea and ovulation in seven and conception in five.