PubMed Health⌕ Search

Biomedical subjects

A M Romanenko

Publications and source records attributed to A M Romanenko.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[The immunohistochemical determination of p53 and of proliferating cell nuclear antigen in the epithelial nuclei of benign prostatic hyperplasia following the accident at the Chernobyl Atomic Electric Power Station].

With the purpose of studying into the morphogenesis and proliferous activity of the prostatic epithelium under a long-term exposure to low doses of ionizing radiation there have been conducted comparative histological and immunohistochemical (expression of p53 and proliferous cellular nuclear antigen-PCNA) investigations designed to study benign prostatic hyperplasia in patients living in those Ukraine territories affected by radionuclide contamination (group III), residents of Kiev (group II), and patients having been operated on before the Chernobyl accident, having constituted the control group I. It has been found out that the incidence of prostatic intraepithelial neoplasia (PIN), the level of nuclear expression of proteins p53 (in the PIN epithelium) and PCNA (in the epithelium of both benign prostatic hyperplasia and PIN) of patients in groups II and III are by far higher as compared with those in group I. The stroma of benign prostatic hyperplasia in patients of groups II and III was clearly different from that in the control group in that the former was characterized by apparent phenomena of hyalinosis, sclerosis, fibrosis, and extensive inflammatory infiltration, which changes can be explained by a long-term systematic exposure of prostatic tissue to low doses of ionizing radiation.

Aged↗
PubMedDate not supplied

[Endoscopic removal of isolated gastrinoma of the duodenum after Billroth II gastric resection].

Duodenal carcinoma is a rare disease and is encountered in no more than 10% of cases of the Zollinger-Ellison syndrome. The article discusses a rare case in which an isolated duodenal gastrinoma was removed endoscopically with subsequent recovery from the Zollinger-Ellison syndrome. Study of the serum gastrin concentration with provocative tests allowed the Zollinger-Ellison syndrome to be diagnosed and the radicality of duodenal gastrinoma removal to be controlled. Retrograde duodenoscopy conducted after resection of the gastric stump by the Billroth II method localized the source of hypergastrinemia and made possible radical removal of the duodenal gastrinoma, which was confirmed by normalization of the blood serum gastrin concentration. The work includes a brief literature reference on the subject.

Duodenal Neoplasms↗
PubMedDate not supplied

[Effect of a new food product--cryl paste--on chemical carcinogenesis].

The influence of a new food product obtained from oceanic shrimp--the cryl on the development of tumours under the effect of chemical carcinogens was investigated. DAB (n-dimethylaminobenzene) induced tumours of the liver in 90.8% of the test rats against the background of a caseine-rich diet and in 21.7% of the animals receiving the cryl paste as a part of their alimentation. With the diethylnitrosamine (DENA) induced tumours the lowest percentage (43) and inhibited development were noted with the rats fed on the cryl paste, and the highest--when feeding the animals of beef (74), whereas in the case of a caseine-rich diet--tumours developed in 50% of the animals. Features specific for morphogenesis of tumours induced with DENA with the animals kept on a diet containing different types of protein and also histo- and biochemical changes in the liver in carcinogenesis were studied.

Adenoma↗
PubMedDate not supplied

[The clinico-morphological aspects of aspermia].

The clinico-morphologic, clinico-endocrinologic, and morpho-endocrinologic parallels were studied in 126 males with aspermia who underwent genitography and biopsy of the testes. On the basis of the findings, the structure of male sterility in aspermia was exactly identified and the differential diagnostic value of certain values was established; a correlation between the blood follitropine content and the degree of spermatogenesis inhibition in testicular aspermia was revealed in particular. Testosterone excreted in the urine and circulating in blood plasma is reduced by more than three times in this case, while the plasma estradiol level increases 1.5 times. Obturation aspermia accounts for 12.7% and testicular aspermia for 87.3% of all cases of aspermia. Further search for clinico-laboratory and laboratory differential diagnostic criteria in aspermia is necessary. The modern methods of treatment are ineffective.

Adult↗