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Biomedical subjects

A M Rosenthal

Publications and source records attributed to A M Rosenthal.

13 recordsLinked to original sources
PubMed1986

Computed tomography--its principles and application to the diagnosis of facial fractures.

The introduction of microcomputers with their chips of integrated circuits and ability to rapidly perform thousands of complex mathematical instructions has enabled the clinician to readily use and manipulate tomographically acquired data from relatively narrow body slices. These data allow identification of complex injuries and disease states through the construction of detailed anatomic images and the differentiation of structures of low densities and those of subtle density differences.

Adolescent↗
PubMed1983

Revascularization surgery: impact on lower extremity amputations.

The effect of revascularization surgery on the amputee population of 2 hospitals (VA and private) was studied in 2 time periods a decade apart--1969-70 and 1979-80. In the VA hospital there was a trend toward below-knee surgery over time; however, for patients who had prior vascular reconstruction and who ultimately came to amputation there was no change in the proportion of below-knee to above-knee surgery at either hospital. At the private hospital the average age of patients who underwent amputation increased significantly and the proportion of patients requiring amputation to the total number of patients undergoing vascular reconstruction significantly decreased in the later time period.

Aged↗
PubMed1980

25-hydroxyvitamin D3 metabolism by isolated perfused rat kidney.

Kidneys of adult rats were removed and perfused with semisynthetic media with the object of elucidating the separate actions of factors implicated as modulators of renal metabolism of 25-hydroxyvitamin D3 (25(OH)D3). During a 3-h perfusion with 3[H]25(OH)D3, the kidney produced high yields of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) or 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) depending on whether the rat had previously been, respectively, normocalcemic, normophosphatemic, vitamin D-replete or hypocalcemic, hypophosphatemic, vitamin D-deplete. With longer perfusion (up to 12 h), kidneys from normocalcemic, normophosphatemic, vitamin D-replete rats mainly produced 24,25(OH)2D3 but also amounts of 1,25(OH)2D3. This pattern was unaltered by reducing Ca or Pi concentrations of perfusate or by adding parathyroid hormone. Kidneys of hypocalcemic, hypophosphatemic, vitamin D-deplete rats perfused with low Ca, low Pi medium for 12 h at first produced 1,25(OH)2D3 exclusively. However, 24,25(OH)2D3 appeared after 4 h and accumulated thereafter, whereas 1,25(OH)2D3 synthesis ceased after 7 h, a metabolic pattern unaffected by the concentration of substrate or end products in the perfusate or by addition of cyclic AMP. The model shows promise for studying regulation of 25(OH)D3 metabolism by the kidney.

Animals↗