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Biomedical subjects

A M Schellen

Publications and source records attributed to A M Schellen.

14 recordsLinked to original sources
PubMed1980

Preliminary experience with a 'sub-50' combined oral contraceptive, containing 35 micrograms ethinyl oestradiol and 1 mg norethisterone ('NeoCon').

The present trend in oral contraception is clearly in favour of the 'sub-50' pills, taking into consideration the recent publications on the association between cardiovascular affections and pill intake. 'NeoCon', a combination pill containing 1 mg norethisterone and 35 micrograms ethinyl oestradiol, has been investigated in the United States, Mexico, Germany, Belgium and the United Kingdom. From all these studies, it could be concluded that it is an effective and well-tolerated oral contraceptive. From the present series, totalling 104 patients with 1232 cycles, first clinical impressions confirm the evaluations of other investigators: no pregnancies, only mild cycle disturbances disappearing after a few adaptation cycles, few side-effects and excellent tolerance. Due to the low potency and the low contents of its components, it is suggested that 'NeoCon' is appropriate for all women in general and for the younger women in particular.

Adolescent↗
PubMed1976

Double-blind trial of prostaglandin F2alpha and oxytocin in the induction of labour.

In a random double-blind trial in 28 pregnant women at term, labour was induced with either prostaglandin F2alpha or oxytocin given by intravenous infusion. The results showed that prostaglandin F2alpha was as active as oxytocin and induction was successfully carried out in 24 patients; 3 patients had a caesarean section because of an obstructed labour and 1 patient on oxytocin did not have regular contractions after 10-hours' infusion although she delivered spontaneously 2 days later. No difference was found in the induction--delivery interval in the 8 patients in each group who had early amniotomy (first 90 minutes). No adverse effects were noted in either mother or the child. The authors recommend that to avoid side-effects the dosage of 20 mug prostaglandin F2alpha per minute should not be exceeded and that, although no cardiotocographic abnormalities were noted, this method of control should be used.

Adult↗