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Biomedical subjects

A M Shilov

Publications and source records attributed to A M Shilov.

At least 19 recordsLinked to original sources
PubMed2006

[Nitrates in the practice of treatment of cardiovascular diseases].

Mechanisms of emergence of endothelial dysfunction underlying development of ischemic heart disease with peculiarities of its 24-hour cycles are considered in detail. Data on metabolism of organic nitrates, determining basis of "replacement" therapy with nitrates in deficit of nitric oxide (endothelium dependent factor of relaxation) are summarized. Results of multicenter controlled studies on comparative assessment of therapeutic efficacy of tri-, di-, and mononitrates are discussed. High antianginal efficacy of once daily administration of a drug with original pharmacokinetics--isosorbide-5-mononitrate in good tolerability and minimal side effects is shown.

Angina Pectoris↗
PubMed1986

[Relation between the extent of the myocardial lesion and the state of the coronary bed in acute myocardial infarction].

The probability of combined lesion of both ventricles in acute myocardial infarction (AMI) is discussed. In cases of proximal stenosis or occlusion of the right coronary artery, both inferior and right-ventricular (RV) AMI may develop. ECG recordings from the V3R-V6R, V3RIII, V4RIII leads were used for the diagnosis of RV AMI. Elevated ST segment plus the formation of Q waves and a negative T wave in the recordings from these leads indicate RV AMI in the presence of inferior AMI. The extent of myocardial lesion, estimated on the basis of maximum plasma MB CPK activity, is greater in cases of inferior AMI with electrocardiographic signs of RV AMI, as compared to inferior AMI free of such signs.

Clinical Enzyme Tests↗
PubMed1986

[Central hemodynamic characteristics of patients with acute myocardial infarct of the right ventricle].

A study of central hemodynamic parameters and clinical patterns of acute right-ventricular myocardial infarction (ARVMI) is reported. Thirty-nine patients with acute inferior left-ventricular myocardial infarction were divided into 2 groups: 28 patients with electrocardiographic signs of ARVMI (group 1) and 11 patients showing no such signs (group 2). All patients were subjected to catheterization of the heart's right compartments, and their minute blood volumes were measured by thermodilution. Three patterns of ARVMI were identified on the basis of the mean pulmonary arterial blood pressure: hypo-normo- and hypertensive ones. All the three were associated with the development of prevailing right-ventricular insufficiency in group 1.

Cardiac Catheterization↗
PubMed1984

[Clinical experience with the use of nitroglycerin in the acute period of myocardial infarct].

The authors summarize the results of treating 1284 patients with macrofocal acute myocardial infarction. In 1097 of these patients the treatment consisted of the intravenous administration of the alcohol solution of nitroglycerin. The control group was comprised of 184 patients whose treatment scheme included no nitroglycerin. The group of nitroglycerin-treated patients showed a decrease in the mortality rate as compared to control, 18.1% and 24.1%, respectively. The drug studied was also found to have an anti-arrhythmic effect. The most optimal timing of nitroglycerin use to limit the area of myocardial ischemia is the first six hours of infarction, later on in the presence of heart failure it is advisable to use this drug in combination with cardiac glycosides. There were practically no complications following the intravenous administration of nitroglycerin.

Adult↗
PubMed1982

[Pathophysiological aspects of heart failure complicating the course of myocardial infarct].

An analysis is presented of the central hemodynamics records obtained by catheterization of the cardiac chambers and echocardiography in 74 patients with acute myocardial infarction (AMI). Administration of vasodilators and anticalcium agents is recommended during first 6 hours of AMI; later, in the presence of clinical symptoms of heart failure, cardiac glycosides should be added. The authors claim that nitroglycerin is a vasodilator and cardiotonic agent whose inotropic effect is mediated through the diastolic phase by eliminating the myocardial contracture during the first hours of AMI.

Adult↗