Guard for prevention of finger-stick injuries caused by stylets.
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Finger Injuries↗
Biomedical subjects
A M Singer
Publications and source records attributed to A M Singer.
Congenital megaureter.
Megaureter is the descriptive term applied to the large, wide, dilated and often tortuous ureter, which is usually congenital. Megaureter may result from a number of causes and an accurate diagnostic classification, such as refluxing, obstructed or non-refluxing, non-obstructed, is essential for appropriate management. The 52 consecutive patients with the various forms of megaureter presented typify the various causes of the entity. Surgical intervention virtually is universal and factors bearing upon recoverability and prognosis have been analyzed.
Classification↗
The adynamic terminal ureteral segment.
Recently, we observed hydroureteronephrosis owing to an adynamic transmural distal ureteral segment associated with a thickened bladder, consequent to bladder outlet obstruction. Histological examination disclosed a loss of intrinsic musculature of the terminal ureteral segment with fibrosis. The importance of this entity is in the fact that upper tract dilatation and deterioration may progress, despite apparently successful correction of the bladder outlet uropathy.
Child↗
The suppressive effect of immunization on the proliferative responses of rat T cells in vitro. II. Abrogation of antigen-induced suppression by selective cytotoxic agents.
Rats given large i.v. doses of ovalbumin or sheep erythrocytes manifest suppressed spleen cell responses (3H-thymidine incorporation) to PHA within hours. Removal of glass wool-adherent cells totally restores responsiveness to that of normal nonadherent spleen cell cultures. Carrageenan, selectively toxic for macrophages, partially restores responses of antigen-suppressed spleen cells in culture, suggesting a supportive role for macrophages in the suppression phenomenon. Treatment of donors with low doses of cyclophosphamide (20 to 50 mg/kg) at the time of antigen injection abrogates the ability of their spleen cells to suppress the responses of normal cells to PHA. The low dose of cyclophosphamide required indicates a target other than the B cell or macrophage and suggests the possibility that cyclophosphamide eliminates the suppressor T cell component of the macrophage-T cell complex.
Animals↗
Measurement of the immune response to an allograft: amino acid incorporation by peripheral white blood cells in man.
The uptake in vitro of 3H-thymidine and of 3H-uridine by white blood cells freshly taken from the recipients of renal transplants has been followed at regular intervals during the period of the patients' hospitalization. In addition, groups of subjects without renal failure undergoing operation and of patients on chronic dialysis have been studied. Of 33 patients undergoing rejection of their kidney, 28 showed a marked rise in the incorporation of thymidine over the period of rejection. However, a similar rise appears to accompany episodes of inter-current infection.
Graft Rejection↗