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Biomedical subjects

A M Skaria

Publications and source records attributed to A M Skaria.

17 recordsLinked to original sources

[Mohs micrographic surgery: concept, technic and indications].

Mohs Micrographic Surgery is a technic to treat severe cutaneous carcinoma. By performing a microscopic and topographic analysis of the whole tissue excised, both a reduction of the surgical margin and margins in normal tissue is obtained. The major indications of micrographic surgery are recurrent basalcell carcinoma after surgery or radiotherapy, not fully excised or localized on the nose and the mediofacial region, some spinouscell carcinoma and dermatofibrosarcoma protuberans.

Humans↗

[Autologous fat transplantation in dermatology].

The technique of autologous fat transplantation (lipofilling) allows to correct congenital or acquired abnormalities of the cutaneous relief. Autologous fat lobules aspired in one site are transplanted by injection in the zone to treat. This technique is performed ambulatory under local anesthesia and it is possible to perform long term correction of dermal or hypodermal atrophy of one to few centimetres.

Adipose Tissue↗

Rotation flap reconstruction for nasal tip defect after mohs surgery.

BACKGROUND: Skin cancer of the nasal tip is frequent, and reconstruction after Mohs surgery might be challenging. The rotation flap is a very commonly used flap for reconstructions on the vertex and the extremities but rarely on the nose. In textbooks rotation flaps in nose reconstruction are rarely mentioned. OBJECTIVE: We present a rotation flap from the caudal tip and the columella of the nose for defects of the lateral tip of the nose. METHODS: With graphics and photographs of case studies we explain the mechanism of placement and movement of the flap. RESULTS: The rotation flap is useful for reconstructions of medium-size defects of the distal lateral nose tip. CONCLUSION: The rotation flap can be used in the reconstruction of laterally placed nasal tip defects. As this flap is not mentioned in textbooks for nasal tip reconstruction, its value for this localization is probably underestimated.

Humans↗

Refinement of the island pedicle flap: parallel placed release incisions to increase translation movement.

BACKGROUND: The island pedicle flap is a widely used flap for reconstructions in the face and on the extremities. The movement of the flap is limited because of the traditionally inferiorly based pedicle that allowed only rotation or advancement. OBJECTIVE: The purpose was to enhance translation movement by modifying the pedicle. METHODS: The modification of the flap is demonstrated with graphics and documented with photographs. RESULTS: Parallel release incisions did not interfere with the viability of the island pedicle flap. CONCLUSION: Parallel incisions enhance largely the translation vector of the island pedicle flap and the myocutaneous island flap without interfering with the viability of the flap.

Cheek↗

Diagnostic and surgical accuracy and economic aspects of dermatological surgery - a pilot study.

BACKGROUND: Good skin care for oncological dermatological patients includes efficacious excision to achieve tumour control and economically reasonable costs. This field concerns dermatologists as much as other surgical specialities. METHODS: Of 944 excisions and biopsies, we studied 114 epidermal carcinomas excised by plastic surgeons and dermatologists. This allowed us to compare the accuracy concerning oncological surgical aspects as well as the extrapolated costs produced by these two specialities. RESULTS: Dermatologists are significantly more accurate concerning total excision of epidermal tumours compared to plastic surgeons. CONCLUSION: From an economic point of view, plastic surgeons are increasingly more expensive than dermatologists. Most expenses are due to the use of a hospital operating room.

Aged↗

The buried running dermal subcutaneous suture technique with a tacking knot.

BACKGROUND: The buried running dermal subcutaneous suture is an excellent suture technique. A basic problem of this suture is burying and unraveling of the final knot. OBJECTIVE: To describe a tacking knot which allows to bury the final knot into deep subcutaneous tissue and to secure the final knot. METHODS: With the use of photographs and detailed description the technique is demonstrated. RESULTS: The description of a new suture technique. CONCLUSION: This suture is more rapid for closing, shows good eversion of the wound edges, provides excellent strength, and relieves wound tension uniformly. The tacking knot prevents unraveling of the final knot and allows to bury the latter deep into subcutaneous tissue.

Dermatologic Surgical Procedures↗

Multiple hyperkeratotic spicules and myeloma.

We report the case of a 58-year-old patient with multiple myeloma with a monoclonal gammopathy of the IgG type, who developed a striking eruption characterized by multiple hyperkeratotic spicules of the face, nose and scalp. Light-microscopic studies revealed a follicular orthohyperkeratosis, while direct immunofluorescence microscopy remained negative. Hence, our patient presented features characteristic of a rare distinctive disorder associated with an underlying paraprotein or multiple myeloma, paraneoplastic hyperkeratotic spicules.

Humans↗

Takayasu arteritis and cutaneous necrotizing vasculitis.

Takayasu arteritis (TA) is an inflammatory arteriopathy involving predominantly the aorta and its main branches. The disease evolves in two phases: a first, nonspecific inflammatory stage and a late 'pulseless' stage, in which complications related to arterial stenosis and aneurysm formation predominate. In both phases, skin manifestations, such as inflammatory nodules, erythema-nodosum- and pyoderma-gangrenosum-like ulcers, have been described. We report 2 patients with TA, who had cutaneous necrotizing vasculitis as presenting manifestation of the disease. A review of the literature revealed 8 similar cases. TA does not only involve large arteries, but also small blood vessels. The observation that in TA the inflammatory process of the large arteries affects regions of the walls supplied by the vasa vasorum, the anatomy of which bears resemblance to the cutaneous vessel system, suggests that primary involvement of small vessels contributes to the development of the clinicopathological features of TA. Knowledge of the skin manifestations associated with TA remains important for its diagnosis and prompt instauration of life-saving treatment.

Adult↗

[Atrophic polychondritis with multiple arterial occlusions].

A 68-years old patient with relapsing polychondritis of the ear developed stenosis and occlusion of hercarotid and femoropopliteal arteries. Relapsing polychondritis is a rare systemic disorder which may take a fetal course. We also review this rare, systemic disorder.

Arterial Occlusive Diseases↗

Epiluminescence videomicroscopy: black dots and brown globules revisited by stripping the stratum corneum.

BACKGROUND: The pattern and distribution of several elementary structures, such as black dots and brown globules, observed by epiluminescence microscopy (ELM) are valuable to the diagnosis of pigmented lesions. Black dots are considered to be focal accumulations of melanin in the stratum corneum, and brown globules are thought to be clusters of nevocytes at the dermoepidermal junction. Because of their distinct locations within the layers of the skin, black dots might be removed by stripping of the stratum corneum whereas brown globules should not. OBJECTIVE: Our purpose was to evaluate the efficacy of ELM features to identify brown globules and black dots and to analyze the relation of these structures within the pigmented network. METHOD: The distribution and number of black dots and brown globules from 27 benign melanocytic lesions were analyzed by videomicroscopy before and after a stripping procedure. Several lesions were observed for months to see whether the pattern before stripping is reconstituted. RESULTS: Before stripping, 549 black dots and 214 brown globules were identified by means of three criteria: color, contour, and size. Ninety-eight percent of black dots were superimposed on the gridlines of the pigmented network. Stripping removed 56% of black dots and only 10% of brown globules. Eighty-two percent of the black dots that could be stripped were superimposed on the gridlines of the pigmented network. On follow-up, both black dots and brown globule-like structures previously removed by stripping were restored at their initial locations within a few months after stripping. CONCLUSION: The close association of black dots with the gridlines of pigmented network should be taken as one criterion to identify black dots. Half the structures identified as black dots by ELM are not localized in the stratum corneum but rather correspond to vertical stacking of pigment within the epidermis. Accumulation of melanosomes in the stratum corneum may take the appearance of brown globules.

Humans↗

[Arterial occlusion in cutis marmorata teleangiectatica congenita].

Cutis marmorata teleangiectatica congenita (CMTC) is a rare congenital vascular disorder of the venous system. In 50% of cases there are associated anomalies of other organ systems. Clinical improvement of the cutaneous manifestations is noted in most cases and usually occurs during the first year of life. We present a patient with CMTC with a band-like pattern following the L3 dermatome. At the age of 13 years, the skin manifestations worsened, with ulcerations and intermittent claudication. Angiographic imaging revealed stenosis of the deep femoral artery, and the circumflex femoral artery and the first perforating arteries were not visualized. To our knowledge, this is the first reported case of CMTC with anomalies of the large arteries.

Adolescent↗

[Metastatic aspergillus panniculitis in blast transformation of a myelodysplastic syndrome and agranulocytosis].

We present a 58-year-old patient with disseminated aspergillosis and metastatic panniculitis. He suffered from agranulocytosis and blastic transformation of a myelodysplastic syndrome. The skin lesion showed a single subcutaneous inflammatory nodule, which was clearly shown by histolog to be of embolic origin. This clinical presentation has not previously been described. Disseminated aspergillosis is found mainly in immunocompromised and neutropenic patients and the mortality is high. The present case demonstrates how histological examination together with skin biopsy culture can allow the diagnosis.

Agranulocytosis↗