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Biomedical subjects

A M Skorobogatyĭ

Publications and source records attributed to A M Skorobogatyĭ.

At least 19 recordsLinked to original sources
PubMed1991

[Biorhythms and the seasonality of myocardial infarct].

An analysis of 881 case histories of patients with acute myocardial infarction revealed circatrigentane rhythms of general acute myocardial infarction morbidity and its complications (disorders of rhythm and conduction, circulatory insufficiency) as well as a seasonal character of rise and decline depending on the sex, location and spread of myocardium necrosis. The authors determined the correlation of general acute myocardial infarction with fluctuations of the frequency of the main death causes indicating their close pathogenetic relationship. The obtained data may be of value in the chronotherapy and chronoprophylaxis of acute myocardial infarction and its complications.

Adult↗
PubMed1990

[Pathology of the cardiovascular system and early ventricular repolarization syndrome].

An attempt was made for the first time to determine the prevalence of the early ventricular repolarization syndrome (EVRS) in cardiovascular diseases in order to specify the clinico-electrocardiographic significance of the given electrophysiological phenomenon and its interrelationship with the rate of rhythm and heart conduction disorders. The changes discovered cast doubt on the generally accepted concept of the benign character of the EVRS and orient to the necessity of pharmacological correction in more frequent arrhythmogenic episodes in EVRS carriers suffering from cardiovascular pathology. Some diagnostic methods (electrocardiography, pharmacological tests) have been evaluated and suggested as optimal for diagnosing the EVRS.

Age Factors↗
PubMed1990

[Drug interactions in combination pharmacotherapy].

Data are summarized on the interaction of drugs when several of them are used simultaneously. A scheme is presented based on the principle of location of the drug in the body, correspondence of the preplanned effect and actual efficacy, pharmaceutic, pharmacokinetic, pharmacodynamic phases. These findings allow to objectivize and plan rational, effective and safe treatment. Evaluation of interaction of drugs used simultaneously permits to organize a qualitatively optimal and an economically advantageous variant of pharmacotherapy.

Biotransformation↗
PubMed1989

[The seasonality of disease exacerbation studied for the planning of chronoprophylaxis].

The author summarizes results of a biorhythmological analysis of the frequency of exacerbations of main diseases of the gastrointestinal tract and cardiovascular system. A seasonal character was established for some of these diseases--gastric and duodenal ulcer, chronic gastritis, ischemic heart disease, arterial hypertension, neurocirculatory dystonia of the hypertensive type. It is recommended to use these results for chronoprophylaxis of the mentioned pathological conditions.

Chronic Disease↗
PubMed1989

[The biorhythmologic approach to the planning of chronotherapy of diseases].

The author describes a new biorhythmological approach to optimization of pharmacotherapy of patients--chronotherapy which is based on achievements of chronobiology and is aimed at maximum treatment efficacy by means of prescribing drugs with consideration of the main human biological rhythms. This allows not only to reduce the doses of drugs but also the frequency of their side effects.

Drug Therapy↗
PubMed1987

[Methodological features of teaching clinical pharmacology].

The paper is concerned with experience in teaching clinical pharmacology in the Donetsk Medical Institute. The authors discuss the appropriateness of teaching clinical pharmacology (CP) to fourth-year students, lectures in CP to fourth-, fifth- and sixth-year students in accordance with the study of the main clinical specialties (therapy, surgery, pediatrics, etc.), and introduction of a cycle of lectures and practical studies on CP in the curriculum of clinicians' postgraduate education. In the authors' opinion, a clinician who has mastered CP fundamentals, should be employed on CP teaching.

Education, Medical, Graduate↗
PubMed1986

[Current concepts concerning the syndrome of early ventricular repolarization].

Electrocardiograms of 1000 patients examined in a polyclinic for various diseases and during prophylactic checkups, were analyzed. The syndrome of early ventricular repolarization (SEVR) was detected in 54 (5.4%) patients. According to the proposed classification scheme of SEVR one could determine its clinical value and the distribution of frequency of its variants and types. The authors put forward present-day ideas as to SEVR assumed genesis with an attempt to verify some of them. Differential-diagnostic pharmacological tests (procainamide, quinidine and propranolol) were recommended for SEVR recognition.

Adolescent↗