Biomedical subjects
Publications and source records attributed to A M Spencer.
The functional and behavioral aspects of children require age-dependent orthotic therapy. For excessive pronation, these age groups have been discussed: 7 to 18 months, 18 months to 3 years, 3 to 6 years, 6 to 10 years, and over 10 years. Intoeing, out-toeing, pes cavus, peroneal spastic flatfoot, calcaneal apophysitis, and os vesalianum therapies with orthotics have also been outlined.
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The relationship between Na-K-ATPase activity and p-aminohippurate (PAH) transport was examined in renal cortical slices of mixed-breed rabbits by using ouabain to vary the level of Na-K-ATPase activity. Ouabain increased passive PAH uptake, measured in the presence of probenecid. Slice homogenate Na-K-ATPase activity was inhibited by 50% with about 2 X 10(-6) M ouabain. When the concentration was 10(-5) M or above, active PAH uptake was inhibited. Lower concentrations (10(-7) and 10(-6) M) of ouabain stimulated active PAH uptake. Acetate stimulated PAH uptake when medium ouabain was less than 10(-4) M. Ouabain, 10(-5) M and higher, caused intracellular K+ to fall and Na+ to rise. The changes in active PAH uptake observed with ouabain correlated much better with changes in intracellular K+ or Na+ levels (P less than 0.01) than with changes in slice homogenate Na-K-ATPase activity. Vmax for active PAH uptake decreased with 5 X 10(-5) M ouabain, and tended to increase with 10(-7) M ouabain. Ouabain did not alter Km for active PAH uptake. The data support the hypothesis that there is a functional link between active PAH transport and Na-K-ATPase activity. This linkage may be an indirect one mediated by changes in intracellular cation concentrations.
The effects of storage pH and temperature on pancreatic amylase, lipase and trypsin in duodenal fluid were studied. All the enzymes were most stable when stored at --20 degrees C, while the optimum storage pH was found to depend on the particular enzyme under investigation.
The results of 200 radioisotope pancreatic scans in a general hospital show that 32 scans were recorded as "false positives," though these included 13 patients with diabetes mellitus and nine who had had truncal vagotomy. There were no "false negatives." Scanning is a useful diagnostic tool and a distinct advance on other tests more usually available for testing pancreatic function.
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