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Biomedical subjects

A M Tokmakov

Publications and source records attributed to A M Tokmakov.

4 recordsLinked to original sources
PubMed1989

[Structural bases of the decrease in nonspecific antibacterial resistance of the body, related to the functioning of the neutrophil system].

Light optic and ultrastructural examinations of neutrophilic phagocytosis in patients with phlegmons in test system revealed morphological changes in the cells. The changes were proposed by the authors to be regarded as a criterion for assessing the antibacterial resistance of the body. Moreover, a unique approach was developed to the overall assessment of phagocytic indices, providing characterization of two neutrophilic performance types: balanced and extensive. When neutrophils begin to function extensively, this may be considered as a reflection of their relative functional inadequacy.

Cellulitis↗
PubMed1988

[Ultrastructural manifestations of the membrane activity of neutrophilic leukocytes].

Phagocytic function of neutrophils is associated with activation of cell membranes. Neutrophil membranous activity is considered for patients with inflammatory and purulent diseases. It appeared not uniform and served the basis for division the neutrophils into three groups. Group I neutrophils are inactive, being not involved in phagocytosis, but bearing bactericidal potential; their membranes are stable. Group II neutrophils show moderate activity, phagocytizing and inactivating bacteria; phagocytosis proceeds without cell destruction. Group III neutrophils cause membranes hyperactivation with resultant dysfunction of phagocytes, phagocytosis involves both bacteria and surrounding protein substrates, immature phagosomes and vacuoles are produced, membranes are unstable. With aggravation of the inflammation and suppuration, the number of blood hyperactivated neutrophils increases.

Blood Bactericidal Activity↗