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Biomedical subjects

A M Tucker

Publications and source records attributed to A M Tucker.

5 recordsLinked to original sources

Realizing the potential of practice pattern profiling.

In January 1992, the Physician Payment Review Commission held a conference to learn about the appropriateness of present uses of profiling of practice patterns, and to identify what will be required to realize the full potential of this technique in the future. The conference addressed the data needs of profiling, the development of valid and relevant profiles, the impact of profiles on medical practice, and controversies surrounding public access to profiling information and the uses to which profiling has been put. This paper, based in part on that conference, reviews the basic concepts that underlie profiling and describes the roles that profiling can play in quality improvement, assessment of provider performance, and utilization review. It uses case studies to illustrate the types of problems that have arisen in actual usage and discusses what will be required to resolve them. The final section describes the roles that profiling can play in achieving the goals of health care reform, and concludes with what is needed in data and infrastructure development to improve the quality and usefulness of profiling.

Data Collection

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

Transforming growth factor beta (TGF-beta) is angiogenic in vivo. In vitro, endothelial cell proliferation is inhibited by TGF-beta. We have correlated this inhibitory effect with an increase in cellular fibronectin synthesis and deposition in a two-dimensional culture system using specific matrix coatings. The inhibitory effect was mimicked by addition of soluble fibronectin to cultures. In contrast, TGF-beta was found to elicit the formation of tube-like structures (mimicking angiogenesis) when microvascular endothelial cells were grown in three-dimensional collagen gels. In this culture system TGF-beta elicited rapid extensive formation of complex, branching, tube-like structures, while cell proliferation was not inhibited. These data confirm and support the hypothesis that TGF-beta is angiogenic and may exert some of its effects through modulation of matrix synthesis and are consistent with the hypothesis that the organization of the extracellular environment influences cellular responses to this "panregulin."

Angiogenesis Inducing Agents

Self-assessment of hearing impairment: test of the expanded hearing ability scale questionnaire on hearing impaired adults in England.

The National Center for Health Statistics developed a questionnaire for self-assessment of hearing impairment which has been widely tested in the United States. The performance of this questionnaire was tested on a sample of 131 people in England, known to have hearing impairment and gave results very similar to those obtained in the United States. These results are compared with a randomly selected sample from the general population. Characteristics of the hearing ability scale derived from the questionnaire are discussed and some suggestions made for a modified version of the questionnaire. The relationship between the average pure tone threshold and the score derived from the hearing ability scale questionnaire is described and takes the form of a bounded relationship with scale score indicating the minimum threshold level.

Adolescent