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Biomedical subjects

A M Veltman

Publications and source records attributed to A M Veltman.

8 recordsLinked to original sources
PubMed1988

Particulate contamination in solutions of antibiotics packed as dry powders in vials.

The particulate contamination in 12 formulations of antibiotic solutions in vials packed as dry powders from five South African sources has been analysed quantitatively using a HIAC PC 320 light blockage particle analyser linked to a CMB 60 sensor. Results showed that the level of particulate contamination fell well within the limits set by the USP XXIst Edition for Small Volume Parenterals although four formulations contained some particles greater than or equal to 50 micron. There was no apparent difference between the quality of the same antibiotics from different sources or between vials of the same antibiotics packed in different strengths.

Anti-Bacterial Agents↗
PubMed1987

Bioavailability of amfepramone hydrochloride sustained release pellets formulation in healthy subjects.

The relative bioavailability and pharmacokinetic profile of two amfepramone (diethylpropion) hydrochloride oral preparations were evaluated in 12 normal volunteers using a newly developed gas-liquid chromatographic procedure to monitor the unchanged drug and its two major metabolites in urine, plasma and saliva. The sustained release pellets formulation (Regenon retard) provided excellent bioavailability and gave broad plateau levels extending over 6 to 8 h after administration, which were intermediate between the "peaks and troughs" shown by the same total dose of the free drug in three equal portions at 4-h intervals.

Adult↗
PubMed1986

Sugar-free liquid pharmaceuticals.

With the reported increased incidence of dental disease in chronically ill children receiving sugar-containing medicines, health care personnel should be made aware of the availability of sucrose-free paediatric preparations. The list of sugar-free liquid preparations for oral use presented will require updating as more products are reformulated to avoid inclusion of fermentable carbohydrates.

Child↗
PubMed1986

Simultaneous determination of amfepramon and its two major metabolites in biological fluids by gas liquid chromatography.

Sensitive and specific procedures based on gas liquid chromatography for the identification, separation and determination of amfepramon (diethylpropion) and its major metabolites ethylaminopropiophenone and diethylnorpseudoephedrine in human plasma, saliva and urine have been described. Acidification of the biological fluid samples has improved the stability of the compounds under conditions of storage.

Biotransformation↗
PubMed1985

Ethanol content of some pharmaceuticals available in the RSA.

The Medicines Control Council is concerned about the influence of the simultaneous ingestion of alcohol and medicines on certain psychomotor functions and the consequent inability of the consumer to perform tasks which require mental clarity. Health care personnel should be aware of the alcohol content of medications when counselling patients receiving drugs against alcoholism or patients who should avoid alcohol. A compilation, short-listed from over 300 ethanol-containing prescription and non-prescription drug products available in the RSA, is presented.

Ethanol↗
PubMed1985

Particulate contamination in ampoules.

The particulate contamination in 19 formulations of solutions in ampoules supplied by eight South African manufacturers, thirty-three batches in all, was analysed using a HIAC PC 320 light blockage particle analyser linked to a CMB 60 sensor. Results showed that the level of contamination was generally low and that, where comparisons could be made, manufacturers both of the ampoules and the solutions maintained similarly high standards. Problems in this field appeared to be related to the formulation or the quality of the raw material.

Drug Contamination↗
PubMed1975

Determination of polythiazide in pharmaceutical dosage forms by high-pressure liquid chromatography.

A method is presented for the quantitative analysis of polythiazide tablets by high-pressure liquid chromatography. The powdered tablets are extracted with methanol, containing quinoline as the internal standard, and assayed by comparison of peak heights after liquid chromatography. The chromatographic conditions employed may be adapted for the determination of many other thiazide and nonthiazide diuretics.

Chromatography↗