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Biomedical subjects

A M Weindling

Publications and source records attributed to A M Weindling.

At least 73 records · Page 4Linked to original sources
PubMed1988

ABO incompatibility.

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ABO Blood-Group System↗
PubMed1988

Does ABO incompatibility matter?

The incidence and severity (peak serum bilirubin concentration) of clinically detectable jaundice was determined retrospectively in 110 elution positive cases of ABO incompatibility. Neither the incidence nor the severity of jaundice in the study group differed significantly from a control group. In the individual case Coombs positivity and/or a strongly positive elution test may be a helpful predictor of jaundice occurring but not of its severity.

ABO Blood-Group System↗
PubMed1988

Phototherapy and the use of heat shields in very low birthweight infants.

The irradiance produced by phototherapy units in use on a neonatal unit was measured. The phototherapy tubes were found to decline at a variable rate. Heat shields used to decrease heat and evaporative losses in the very low birthweight infant reduce irradiance and may appreciably limit the effectiveness of phototherapy.

Critical Care↗
PubMed1987

Monitoring of end tidal CO2 in neonatal intensive care.

The use of monitoring end tidal carbon dioxide pressure (PetCO2) in neonatal intensive care was studied in 19 infants with respiratory disease. PetCO2 correlated poorly with arterial pCO2, the relation being principally determined by the severity of pulmonary disease. Monitoring end tidal CO2 cannot be recommended for neonates with pulmonary disease.

Carbon Dioxide↗
PubMed1985

Development of cerebral palsy after ultrasonographic detection of periventricular cysts in the newborn.

Cysts in the periventricular region of the brain were demonstrated by ultrasound in eight of 102 preterm infants (birthweight less than 1501g or less than 34 weeks gestation) during a 14-month period. All eight babies survived, but developed serious neurological problems: five had spastic quadriplegia and three had spastic diplegia. Six had impaired vision and six had delayed speech development, but there was no evidence of impaired hearing. The cysts probably represent the infarcted lesions of periventricular leukomalacia.

Cerebral Hemorrhage↗
PubMed1985

Perinatal events which precede periventricular haemorrhage and leukomalacia in the newborn.

Ultrasound brain scans were obtained daily for the first 5 days after birth, on day 7 and then weekly until discharge from hospital in 86 babies during a 12-month period. The babies weighed less than 1501 g or were less than 34 weeks gestational age. Fifty-one (59%) had normal scans, 34 (40%) developed periventricular haemorrhage, and seven (8%) developed periventricular cysts (associated with periventricular haemorrhage in six). Factors associated with periventricular haemorrhage were perinatal hypoxia, acidosis, hypercapnia and hypoxia after birth. Babies who developed periventricular cysts (periventricular leukomalacia) were more likely to have been hypoxic at birth and in four of the seven there had been a maternal antepartum haemorrhage. The association of perinatal hypoxia with periventricular haemorrhage and leukomalacia suggests that intrapartum events may predispose to the onset of these lesions which then develop postnatally. Prevention of perinatal hypoxia may play an important role in diminishing the disability caused by these conditions.

Brain Diseases↗
PubMed1983

Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: the effects of dichloroacetate (DCA).

Soon after birth a 36-week-gestational age, appropriate for dates, newborn infant developed hyperinsulinaemic hypoglycaemia which responded to diazoxide and glucose infusion. While normoglycaemic, he became increasingly ill with high lactate, pyruvate, and alanine levels. Provocation tests suggested a defect in lactate handling. Dichloroacetate (DCA) was given and resulted in the prompt normalisation of his metabolic profile with no recurrence after discontinuation of the drug. A second episode of hyperinsulinaemic hypoglycaemia followed and this was controlled satisfactorily by short term diazoxide treatment. Diazoxide treatment could be stopped at the age of 1 month. Although at the age of 1.5 years the infant is retarded developmentally, there has been no recurrence of lactic acidosis nor hyperinsulinaemic hypoglycaemia. The association of lactic acidosis and hyperinsulinism, and the use of DCA in this circumstance have not been reported previously.

Acetates↗
PubMed1983

Cerebral haemodynamics in newborn babies studied by electrical impedance. Preliminary results.

We report studies in which the amplitude of the cardiac-synchronous change in transcephalic impedance, delta Z, has been used in the investigation of cerebral haemodynamics in newborn babies. Three clinical situations, in which cerebral blood flow might be expected to change, have been studied. The impedance signal, delta Z, decreased in size during a tension pneumothorax, increased slightly with feeding, and, during an exchange transfusion of an asphyxiated baby, there was a consistent increase in the size of the signal during infusion of blood and a decrease in size as blood was withdrawn. This method may be useful for the continuous study of cerebral haemodynamics in the preterm baby over prolonged periods.

Cerebrovascular Circulation↗