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Biomedical subjects

A Mérad-Boudia

Publications and source records attributed to A Mérad-Boudia.

8 recordsLinked to original sources
PubMed1999

[Anthrax: an unusual escharotic lesion].

BACKGROUND: Anthrax is basically an animal disease rarely found in humans. We report a case occurring in a young boy who had minimal signs and a suggestive skin lesion. CASE REPORT: A 16-year-old boy living in the steppe pastures in western Algeria was hospitalized for unexplained long-duration fever. Physical examination and laboratory tests did not suggest any infectious disease among those common in our area: typhoid fever, brucellosis, meningitis. Anthrax was suggested by presence of an escarrotic black plaque measuring 2 to 3 cm localized on the left leg. The lesion was very adherent and surrounded by an inflammatory rim. The diagnosis was confirmed bacteriologically at direct examination and by culture. Pathology found epidermal necrosis without dermal inflammatory infiltration nor vascular thrombosis. Penicillin was effective in 10 days. DISCUSSION: Bacillus anthracis, the causal agent in anthrax, is a Gram positive rod. The disease is generally seen in herbivorous animals contaminated by plant or animal products. Human anthrax is very rare but should not go unrecognized. In humans, skin contamination is the rule, causing first a vesiculopustulous lesion which progresses to an escarrotic plaque with peripheral inflammation localized on exposed areas. In our case, the hidden localization retarded diagnosis.

Adolescent↗
PubMed1998

[Dermatophytic disease: exuberant hyperkeratosis with cutaneous horns].

BACKGROUND: Dermatophytic disease is a chronic dermatophytosis involving the skin and viscera and caused by benign dermatophytes which cross the skin barrier. We present a case presenting previously unreported giant cutaneous horns. CASE REPORT: A male Algerian patient aged 29 years consulted for chronic skin disease which had progressed for 2 years. Manifestations included warts, papulonodules, eczematiform lesions, lichenifications, alopecia, onyxis, multiple node enlargement and giant cutaneous horns on the plantar aspect of the feet making walking difficult. The patient's kinhood included 10 members and the patient's parents were first cousins; no other family member had a similar disease state. Laboratory findings included eosinophilia (11%, 550 cells/mm3), an inflammatory syndrome, and normal phosphorus and calcium levels despite demineralization of the hands and feet. The tuberculin interdermal reaction was positive but the trichophytine interdermal reaction was negative. Trichophyton violaceum was found in all mycological samples from skin and nails. The histology examination of skin biopsies revealed acanthosis, considerable hyperkeratosis, and myceleal filaments invading the horny layer, the sweat glands and hair follicles. Abscesses and granulomas were also seen in the superficial dermis. Oral griseofulvin 1 g per day and topical applications with ketoconazole gave clear improvement. DISCUSSION: Dermatophytic disease is a chronic dermatophytosis observed mainly in North Africa. The locally high rate of consanguinous marriages would suggest autosomal recessive inheritance of a genetic anomaly possibly associated with deficient cellular immunity. The lesions are polymorphous and develop progressively, probably due to diminished cellular immunity. This case with giant cutaneous horns would be a new variant. Antifungals can provide definitive cure. The pathogenesis of this severe dermatophytosis remains to be established.

Administration, Oral↗
PubMed1995

[Hepato-erythropoietic porphyria].

INTRODUCTION: Hepatoerythropoietic porphyria is a rare congenital form of porphyria with a biochemical pattern of porphyria cutanea tarda. The disease is caused by defect in uroporphyrinogen decarboxylase. CASE REPORT: A 3-year-old girl was born to healthy consanguineous parents. From birth she had bloody urine and developed photosensitivity with bullae at 1 year of age. Clinical examination revealed scars resulting from bullae, hypertrichosis of the face and members and abnormal pigmentation. Uroporphyrin and coproporphyrin levels in the urine and erythrocyte protoporphyrin level were elevated. Uroporphyrinogen decarboxylase activity was 37.5 p. 100 of the control, and was 82.5 p. 100 in the mother and normal in the father. DISCUSSION: This case of uroporphyrinogen decarboxylase deficiency in a child and her parents was not as severe as reported in other cases in the literature, confirming the heterogenous nature of hepatoerythropoietic porphyria. It is possible that in this case, the mutation was different than in previous cases.

Child, Preschool↗
PubMed1994

[Allergic vasculitis in brucellosis].

Brucellosis is an anthropozoonosis caused by a Gram negative bacillus of the Brucella gender. Skin manifestations have been reported in 1.5 to 11 p. 100 of the cases. Allergic vasculitis is rare. Recently a 24-year-old man was hospitalized for signs of infection. He had been treated with tetracycline. The clinical picture was suggestive of brucellosis and the Wright test was positive at 1/1,280. There were violet and purpuric papulae on the limbs, arthritis of the knee and ankle joints and renal involvement (haematuria, proteinuria). Histology revealed fibrinoid and leukocytoclastic vasculitis of the small veinules of the subpapillary plexus. Outcome was favourable with rifampicin, doxycycline and adjuvant dapsone, together with bed rest. Several types of skin manifestations have been reported in brucellosis although cases of allergic vasculitis are rare.

Adult↗
PubMed1994

[Chromomycosis: 2 cases].

We report two cases of chromomycosis due to Fonsecaea pedrosoi and Cladosporium herbarum, observed in two women from the Tlemcen region. Due to the wart-like or nodular lesions, these case were mistaken for other skin diseases with similar manifestations, particularly verrucous tuberculosis and cutaneous leishmaniasis. The histology revealed fumagoid bodies leading to the identification of the causative agents. Chromomycosis is rare in Algeria although 3 cases have been observed in our area since 1989. The physician should be aware of this diagnosis.

Aged↗
PubMed1990

[Antifungal agents in dermatophytic disease: failure of griseofulvin, ketoconazole and itraconazole].

The dermatophytic disease is a rare, severe affection caused by banal dermatophytes. A genetically predisposed basis could explain the frequent failure of antifungal therapeutics. We report here the case of a 28-year-old male. Despite 2 years of griseofulvin, 23 months of ketoconazole and 8 months of itraconazole, the therapeutic failure was evident: circinate herpes, papulo-nodules, vegetating plaques, ulceration, superficial and profound adenopathies, cerebral involvement, and deterioration of the general state. The correction of the immuno-deficient state combined with antifungals could be the best therapy.

Adult↗