Histopathological and enzyme histochemical changes in experimental Semliki Forest virus infection in mice and their relevance to scrapie.
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Acetylglucosaminidase↗
Biomedical subjects
A Mackenzie
Publications and source records attributed to A Mackenzie.
Partial isolation and translation in vitro of mRNA species coding for alpha- and beta-subunits of human placental N-acetyl-beta-D-hexosaminidase.
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Cell-Free System↗
Osteogenetic stimulation by externally applied dc current.
A new, simple, safe and noninvasive technique for the electrical stimulation of fracture healing is introduced. The safety and the simplicity of the technique makes it possible to apply it almost immediately to clinical experimentation. Electrodes were applied externally to the fractured site producing current across the limb. It was observed that the current density changes the volume of callus and affects the direction of the trabecular orientation. When the trabecular orientation is completely changed from longitudinal to transverse, the larger volume of callus does not compensate for the loss of strength as compared with the callus on the control bone.
Animals↗
Single dose cephazolin prophylaxis in biliary tract surgery.
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Aged↗
Determination of indole and 3-methylindole in plasma and rumen fluid from cattle with fog fever or after L-tryptophan administration.
A modified gas liquid chromatography method has been developed to analyse the concentrations of indole and 3-methylindole in samples of plasma and rumen fluid from four cows with fog fever together with four control animals and from two cattle given L-tryptophan orally. Satisfactory recoveries of the metabolites were obtained in test samples examined by the gas liquid chromatography procedure and increased levels were found in rumen fluid after tryptophan administration. Absence of abnormal concentrations of the toxic metabolite 3-methylindole in samples from field cases of fog fever was not considered to rule out the metabolite as a possible cause of the disease in view of the rapid restoration of 3-methylindole to normal levels by the second day after loading with L-tryptophan.
Animals↗
A form of hereditary persistence of fetal haemoglobin characterized by uneven cellular distribution of haemoglobin F and the production of haemoglobins A and A2 in homozygotes.
Thirteen members of a British family were found to have elevated levels of haemoglobin F (Hb F) which segregated into two groups with mean values of 19.8+/-0.52% and 8.9+/-3.1% respectively. Genetic data indicate that the individuals in the former group are probably homozygous, and those in the latter group heterozygous, for the gene causing persistent Hb-F production. There is a significant reduction in the level of Hb A2 in the homozygotes. The Hb F is heterogeneously distributed among the red cells of each of the affected family members. In each case the haematological findings are normal and biosynthetic studies indicate balanced globin-chain synthesis. Chemical studies indicate that the Hb F consists mainly of the Agamma type together with a small (c 10%) but significant amount of the Ggamma type in both homozygotes and heterozygotes. The other red-cell proteins and antigens are of the adult variety in all affected family members. The condition differs from previously described forms of hereditary persistence of fetal haemoglobin by virtue of the heterogeneous distribution of the Hb F and the presence of beta and delta-chain synthesis in homozygotes. Its possible basis as a controller-gene mutation is discussed.
Adult↗