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Biomedical subjects

A Madsen

Publications and source records attributed to A Madsen.

34 records · Page 2Linked to original sources
PubMed1978

A retrospective study of respiratory disease in a cohort of bacon pigs. I. Clinico-epidemiological analyses.

Previous studies of respiratory disease problems in pig herds have to a large extent relied on mortality data and slaughterhouse findings. The present report deals with simultaneously recorded clinical data and post mortem information for individual pigs from a large herd. Among other things, the results suggest that the commonly applied treatments of clinical cases have limited effect, that routine meat inspection is a fairly sensitive tool in monitoring the disease status, that productivity is affected relatively more by clinical episodes than by subclinical occurrence, and that respiratory disease and diarrhea are interrelated in more than one way.

Animals↗
PubMed1976

Experimental porcine nephropathy: changes of renal function and structure perorally induced by crystalline ochratoxin A.

Nine pigs were fed crystalline ochratoxin A in amounts corresponding to a feed level of 1 mg per kg for 3 months. The only observable lesion developed was a kidney damage, identical to the naturally occurring porcine nephropathy. The changes of renal function was characterized by impairment of proximal tubular function, indicated by a decrease of the ratio TmPAH/CIn, of the ability to concentrate urine, and by an increased urinary excretion of glucose. The decrease of the ratio TmPAH/CIn is correlated with time of exposure to ochratoxin A. The changes of renal structure were characterized by degeneration of the proximal tubules, leading to tubular atrophy accompanied by interstitial fibrosis. At the end of the experiment the kidney, liver, adipose and muscular tissue of the slaughtered pigs contained sizable amounts of ochratoxin A residues. As the pigs would have passed the meat inspection this represents a possible health problem. The changes observed in this study are identical to those observed by feeding to pigs grains naturally contaminated with ochratoxin A.

Adipose Tissue↗
PubMed1970

Stereotaxic amygdalotomy and basofrontal tractotomy in psychotics with aggressive behaviour.

Twelve patients with personality disorders or chronic schizophrenia in whom aggressive-destructive behaviour was a prominent feature were treated by bilateral stereotaxic electrocoagulation of the amygdala. In two of the patients a cingulectomy and in five of the patients a frontal lobotomy had been performed several years previously without effect. In 11 of the patients the amygdalotomy resulted in disappearance of, or marked reduction in, their aggressive episodes. In two patients with frequent self-mutilations and reactive psychotic episodes these symptoms disappeared after an additional basofrontal tractotomy by Knight's method.

Adult↗
PubMedDate not supplied

Time-dependent disappearance of ochratoxin A residues in tissues of bacon pigs.

Crystalline ochratoxin A was administered to bacon pigs for one month. After termination of toxin exposure the pigs were slaughtered at different intervals and analyses for ochratoxin A residues in four tissues were conducted. Kidneys contained the highest concentrations, and fat the lowest, at each interval. Ochratoxin A disappeared from muscles and fat after 2 weeks, from liver after 3 weeks, and from the kidneys after 4 weeks. The toxin disappeared from tissues exponentially. All the pigs would have passed the meat inspection because no pathologic lesions were developed although tissues contained mycotoxin residues. The results of this study indicate that contamination of meat by ochratoxin A may be avoided by feeding pigs ochratoxin-free feed during the last 4 weeks before slaughter.

Animals↗
PubMedDate not supplied

Characterization of LlaCI, a new restriction-modification system from Lactococcus lactis subsp. cremoris W15.

The genes encoding the restriction-modification (R/M) system LlaCI have been found on the naturally occurring 7.0 kb plasmid pAW153 in L. lactis subsp. cremoris W15. The R/M system was isolated on a chloramphenicol resistant derivative of the wild type plasmid (pAW153cat). Plasmid pAW153cat and a 2.4 kb HincII-SphI fragment cloned into a high- and a low-copy vector conferred decreased sensitivity in L. lactis LM2301 and L. lactis SMQ86 against small isometric-headed phages of the 936 or P335 species, respectively. Increased plasmid copy number enhanced the level of phage restriction. Sequencing the 2.4 kb HincII-SphI fragment revealed two open reading frames arranged convergently with a 94 bp separation. IlaCIM showed 66% identity to hindIIIM, and IlaCIR showed 45% identity to hindIIIR. The organization of the LlaCI operon differs from the HindIII operon, where the endonuclease and methylase genes overlap and are transcribed in the same direction. The LlaCI methylase is predicted to be 296 amino acids long, with 63% identity to the HindIII methylase, while the LlaCI endonuclease is predicted to consist of 324 or 332 amino acids, depending on the position of the start codon. It shows 24% identity to the HindIII endonuclease.

Amino Acid Sequence↗