PubMed Health⌕ Search

Biomedical subjects

A Magli

Publications and source records attributed to A Magli.

33 records · Page 2Linked to original sources
PubMed1983

Morphological and physiological changes of the eye in patients with congenital heart disease undergoing extracorporeal circulation.

We studied 76 patients with congenital heart disease, whose ages ranged from 2 to 39 years. The following investigations were carried out pre-operatively and post-operatively in all patients: visual acuity, cycloplegic refraction, orthoptic examination, examination of the fundus. Where collaboration was sufficient the following were also studied: kinetic and static perimetry, adaptation perimetry, colour vision, electroretinography. There were no differences before and after operation of visual acuity, adaptation perimetry, refraction, electroretinography or of the fundus. Post-operative changes were only found in 4 of the 65 patients in whom perimetry was performed. By comparison, an identical study of patients with acquired heart disease showed the percentage of functional ocular changes to be higher in this group.

Adolescent↗
PubMed1982

Ocular manifestations in thalassemia minor.

The authors report the results of a study on 96 subjects affected with thalassemia minor. The study was made at the Center for the Study of Microcythemia of the OORR in Naples. Of extreme scientific interest is the finding of ocular involvement in 33.3% of the cases. Therefore, after formulating a pathogenetic hypothesis, the authors plan more involved studies and research on these patients.

Adult↗
PubMed1981

Stevens-Johnson syndrome: a clinical and histological study.

A description is given of a case of Stevens-Johnson syndrome clinically and histologically ascertained in a middle-aged male with typical localization and later chronicity of the ocular involvement. Besides, an outline is drawn of its clinical picture and of the etiopathogenetical hypothesis, dwelling upon the allergic hypothesis though not excluding the iatrogenic one.

Adult↗
PubMed1979

Genetic study and surgical correction of euryblepharon.

Euryblepharon is a rare congenital anomaly of the palpebral fissure which consists of an increase in its width. A case has been described in which this characteristic is very marked, and associated with ectropion, lagophthalmos, corneal ulcers; also congenital malformations as twisted feet, hypospadia and inguinal hernia. Apart from a limited increase of the palpebral fissure in the mother, the familiar anamnesis is negative, and likewise examination of the cariogram and research of eventual metabolic modifications. An estimation of the various surgical techniques proposed revealed insufficient strictness regarding the standards generally followed in palpebral plastic surgery. Consequently, a technical variation was set up that will satisfy the needs of correct anatomical-surgical practice.

Abnormalities, Multiple↗
PubMedDate not supplied

Measuring contrast sensitivity in aretinopathic patients with Insulin Dependent Diabetes Mellitus.

Contrast sensitivity measurements were obtained from 66 patients with Insulin Dependent Diabetes Mellitus (IDDM) and no visible diabetic retinopathy (Group A, n = 30 prepubescent and pubescent subjects; Group B, n = 36 postpubescent subjects). Contrast thresholds were determined for stationary and 6.87 Hz phase-alternating gratings at eight spatial frequencies from 0.18 to 15.7 c/deg. Data from each group of diabetic patients was compared with data from puberty-matched normal subjects. Mean value of the last four determinations of glycohemoglobin Alc (HbAlc) was used as a index of glycemic control. We found that patients with IDDM and no retinopathy had normal contrast sensitivity and that contrast thresholds were not significantly related to sexual maturity, duration of diabetes and glycemic control.

Adolescent↗
PubMedDate not supplied

Laryngeal long-term morbidity after supraglottic laryngectomy and postoperative radiation therapy.

PURPOSE: This study was performed to investigate factors associated with laryngeal morbidity when postoperative radiation therapy (RT) is added to supraglottic laryngectomy. MATERIALS AND METHODS: From 1980 to 1994, 56 patients affected with T1 to 4 N0 to 2c supraglottic squamous cell carcinoma selected for standard (59%) or extended (41%) supraglottic laryngectomy at 2 different institutions were retrospectively analyzed. Most of the patients (91%) also underwent neck dissection. Approximately 80% of the patients had stage T4 primary lesions or N2 neck disease. Postoperative RT was added for presumed microscopic disease at the primary site (13 patients), regional nodes (23 patients), or both (20 patients). Median delivered doses to the larynx and to the neck were 50 Gy (range, 40 to 64 Gy) and 46 Gy (range, 40 to 64 Gy), respectively. Median follow-up for living patients is 11 years (range, 2.8 to 16.9 years). Laryngeal complication was defined as the appearance of grade 2 or higher toxicity according to the European Organization for Research and Treatment of Cancer (EORTC) and the Radiation Therapy Oncology Group (RTOG) scoring systems. RESULTS: Two- and 5-year actuarial locoregional control rates were 85+/-5% and 83+/-5%, respectively. Thirty patients (54%) developed laryngeal complications. However, just one patient experienced grade 4 laryngeal oedema requiring permanent tracheostomy. Estimated actuarial survival without laryngeal complications were 50+/-7%, 43+/-7%, and 39+/-7% at 2, 5, and 10 years, respectively. At univariate analysis, treated volumes (P = .03) and total dose to the larynx (P = .03) were significantly associated with local toxicity. A trend was observed also for the maximum dose to the neck (P = .06) and dose per fraction (P = .09). A multivariate Cox proportional hazards model showed total dose to the larynx to be the only independent predictor of toxicity (P = .03). The hazard ratio of laryngeal toxicity was 2.2 (95% confidence interval: 1.1/4.6), for a total dose to the larynx greater than 50 Gy. CONCLUSION: After supraglottic laryngectomy, postoperative RT to the neck does not affect local morbidity, but careful RT treatment planning is necessary to avoid delivering a total dose to the larynx greater than 50 Gy.

Actuarial Analysis↗
PubMedDate not supplied

Spontaneous resolution of congenital bilateral Brown's syndrome.

We report a case of bilateral Brown's syndrome in a 4-year-old girl. Forced duction testing confirmed the clinical diagnosis. After 7 months we observed a spontaneous resolution in the right eye. The problem in her left eye did not show any significant change over 36 months of follow-up. Various spontaneous resolutions in bilateral cases are reviewed.

Child, Preschool↗
PubMedDate not supplied

Hydrocephalus combined with congenital cataract and microphthalmia.

We describe a case of bilateral microphthalmia with bilateral congenital cataracts associated with hydrocephalus in a 9-month-old girl with consanguineous parents. The differential diagnosis included: (1) congenital rubella syndrome; (2) congenital toxoplasmosis; (3) chromosome alterations; and (4) metabolic disease. However, negative clinical, laboratory, and instrumental investigations excluded all of these hypotheses. We stress the usefulness of echography in establishing whether or not infection has occurred during intrauterine life.

Cataract↗
PubMedDate not supplied

Retraction syndrome with posterior lenticonus.

A case of a 4-year-old child with retraction syndrome and an associated posterior lenticonus is presented. The lack of specific morphological chromosome abnormalities and of any disturbance of amino acid metabolism, in our case, suggests that the retraction syndrome, in nonhereditary types, is the result of dysgenesis during the middle of the third trimester of pregnancy.

Cataract↗