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Biomedical subjects

A Majewski

Publications and source records attributed to A Majewski.

At least 55 records · Page 3Linked to original sources

[Cholescintigraphy for determining focal nodular hyperplasia of the liver?].

The preoperative diagnosis of a focal nodular hyperplasia (FNH) is of special interest as in case of non-malignancy of this tumor no extirpation has to be carried out. 86 patients - 19 of them suffered from FNH - have been examined by 3 phasecholescintigraphy. There were no false positive findings (specifity 100 per cent). 2 out of 23 examined FNH were not recognized as such (sensitivity 87 per cent) because the tumor had been changed regressive largely. Cholescintigraphy is an excellent method to prove FNH not bothering the patient too much. Cholescintigraphy should be the first measure of differential diagnostic clarification whenever a benign tumor is suspected.

Adolescent

Sonographic pattern of focal nodular hyperplasia of the liver.

Focal nodular hyperplasia of the liver (FNH) is a histologically defined benign hepatic tumour, possibly associated with the use of oral contraceptives. The present study deals with the question whether FNH can be distinguished from other lesions of the liver by ultrasonography alone or by a combination of real-time sonography and radiologic procedures. Therefore 18 cases of FNH, 16 females and 2 males, are presented. We retrospectively reviewed the diagnostic results of real-time sonography, hepatic scintigraphy, computed tomography with dynamic CT-densitometry, and angiography on these 18 patients. Ultrasonography enables the identification of the lesion in all of the 18 cases. FNH appears to show varying degrees of echogenicity (slight hypoechoic in 6 cases, isoechoic in 6 cases, and slight hyperechoic in 4 cases). In most of the patients the tumour had similar acoustic characteristics as the surrounding normal liver. By ultrasonography alone there is no possible differentiation of FNH from other hepatic tumours. Both the echo pattern of FNH and the results of the ultrasonically guided cytopuncture are unspecific.

Adolescent

[Computer tomographic densitometry of primary liver tumors].

The dynamic computed tomography (CT) densitometry is defined as the combination of rapid bolus injection of urographic contrast medium and timed sequential computed tomography scan permitting recognition of different patterns of enhancement. The results of this method on fifty patients with histologically proofed hepatic tumors (focal nodular hyperplasia n = 12, cavernous hemangioma n = 13, liver cell carcinoma in cirrhotic liver n = 10, primary liver cell carcinoma n = 6, bile duct carcinoma n = 4, others n = 5) are demonstrated. CT-densitometry offers valuable aid for the differential diagnosis of focal liver lesions, i.e. cavernous hemangioma, focal nodular hyperplasia of the liver.

Adenoma, Bile Duct

[Results of computed tomographic diagnosis of recurrences of colorectal cancer].

Postoperative CT was performed in 179 colo-rectal carcinoma patients who had undergone abdominoperineal extirpation (n = 71), resection and rectosigmoid anastomosis (n = 37), hemicolectomy (n = 32), resection of sigma (n = 31), and others (n = 8). Normal CT-findings were found in 25% only, in more than 75% of all cases pathological CT-findings were seen. CT detected local recurrence in 87 patients. Based on CT findings local recurrent colo-rectal carcinoma was classified as Stage 0, or intraluminal mass, in 2 patients (2%). Stage 1, or extraluminal mass without invasion of adjacent organs, was found in 38 (44%) patients; Stage 2 a, tumor mass with direct invasions of adjacent organs but not the pelvic side walls could be demonstrated in 13 (15%) of the cases; Stage 2 b, or extension of mass to pelvic side walls, and Stage 3, or distant metastatic disease, was found in 14 (16%) and 20 (23%) patients. CT was negative in 2 patients with local recurrence (beside Stage 0), an incorrect diagnosis of recurrence due postoperative scarring was found in 4 patients. CT detected exclusive also metastatic disease of the liver in 23 patients and intraabdominal lymph node involvement in 8 patients.

Adult

[Computer-tomographic evaluation of tumors of the pelvis (author's transl)].

Some cases selected from a group of 35 patients with bone tumors of the pelvis (16 primary, 15 secondary malignant neoplasia, 3 semimalignant tumors, and 1 benign tumor) serve to demonstrate the significant information gained by computed tomography. In bone tumors of the pelvis neither conventional radiography nor angiography render reliable information about the extent of the tumor. Computed tomography is helpful in showing the intra- and extraosseous extent of the lesion, in demonstrating the relationship of the tumor to the organs in the neighbourhood, in measuring of volume and density and discovering the recurrence of tumor.

Adolescent

[Focal nodular hyperplasia of the liver--is a radiologic diagnosis possible? (author's transl)].

Focal nodular hyperplasia of the liver (FNH) is a histologically defined benign tumor, which can be distinguished from other space-occupying diseases of the liver. The present paper deals with the question whether FNH can be distinguished from other lesions of the liver by a combination of radiologic procedures. Therefore 10 patients with FNH of the liver underwent sonography, hepatic scintigraphy, computed tomography with dynamic CT--densitometry, and angiography. The computed tomography with dynamic CT--densitometry using intravenous bolus injection of contrast medium seems to be the most accurate method for detection of FNH of the liver.

Adolescent

[Malignant fibrous histiocytoma of bone (MFH)--an new tumour? ].

Malignant fibrous histiocytoma of bone (MFH) is a histologically defined bone tumour, which can be distinguished from osteo- and fibrosarcomas. The present paper deals with the question whether MFH can be distinguished from these tumours on clinical grounds. One hundred and fifty-seven previously published, and four additional cases have been analysed with respect to their localisation and their biological, clinical and radiological behaviour and their prognosis. It was found that MFH can be distinguished from osteosarcomas on clinical grounds and that this is significant in relation to treatment; its distinction from fibro-sarcomas is clinically not justified.

Adolescent

[The influence of general operation risks on the indications for operations for gynaecological cancers (author's transl)].

The increase of high general operative risks in women presenting for gynaecological operations suggested the investigation of the influence of these risks on the choice of treatment of gynaecologic cancers appropriate for the stage. The primary treatment of 426 gynaecologic and breast cancers of the year 1977 is reviewed. There were 53 endometrial carcinomas, 29 ovarian carcinomas, 185 breast cancers, 142 carcinomas of the cervix and pre-invasive carcinoma of the cervix. There were 17 other carcinomas. 354 patients were selected for operative treatment. 72 patients were selected for primary radiotherapy. A considerable number of patients (40-60%) were selected for treatment appropriate for the stage of the cancer by a system of diagnosis of risks, classifications of risks, evaluation of risks and pre-operative treatment of operative risks. The choice of the cancer treatment appropriate to the stage is not influenced by single risks but by the sum of the general operative risks. Typical mistakes in evaluation of operative risks versus indications for the operations are described in case reports. The reports include avoidable and unavoided risks.

Breast Neoplasms

[Estrogen therapy in carcinoma of the breast (author's transl)].

The controvery about the increase of carcinoma of the endometrium following estrogen therapy led to an investigation of the correlation between estrogen and cancer of the breast because of the close link between carcinoma of the endometrium and carcinoma of the breast. In the statistical matched pair comparison 120 cases of carcinoma of the breast were compared with thoroughly selected controls. To each patient with carcinoma of the breast a control person with essentially the same risk factors was assigned. It was found that: 1) Estrogen therapy in general does not lead to an increased risk for carcinoma of the breast. 2) The separate evaluation of different estrogen preparations showed no increase of the risk. 3) The risk was not increased by prolonged treatment with estrogen. 4) The number of patients taking conjugated estrogens was higher in the control group than in the carcinoma group. 5) The coincidence of estrogen treatment with the other risk factors of nulligravity, hypertension and obesity did not result in an increased risk for carcinoma of the breast.

Adult

[Small pulmonary nodular opacities in inflammatory and granulomatous lung disease (author's transl)].

Small pulmonary nodular opacities are usually visible only due to the summation of several small foci. The size of a single focus and its number per area determine their radiographic appearance either that of small nodular lesions, or of a reticular pattern or of diffus opacification. The small nodular pattern is primarily observed in lung disease beginning in the interstitium rather than the alveoli. Pattern and course of small nodular lung lesions give important differential diagnostic clues.

Alveolitis, Extrinsic Allergic

[Breast biopsies which failed to show cancer (author's transl)].

A review is presented on 520 patients who had biopsies of the breast which did not show cancer between 1972-1974. These patients are compared to 304 patients whose biopsies definitely showed cancer of the breast and 520 patients who came to the hospital because of well defined gynaecological disease such as uterine fibroids or uterine prolapse. Comparison of these groups regarding age, past history, indications for the biopsy showed that patients with a biopsy without proof of cancer are difficult to follow for diagnosis. Follow-up on these patients is difficult, however, it is important since up to 4% of these patients with previous negative biopsies later have cancer of the breast. A decrease of biopsies in favor of non-surgical diagnosis of breast lesions can only be recommended under optimal conditions. Under other circumstances the risk of cancer of the breast is high enough to justify a liberal indication for breast biopsies.

Adult