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Biomedical subjects

A Maleeva

Publications and source records attributed to A Maleeva.

At least 19 recordsLinked to original sources
PubMed1993

[Serum E2 and progesterone levels in patients with atypical hyperplasia and endometrial carcinoma].

The authors study the serum levels of E2 and progesterone in 62 women with endometrial cancer and in 16 with atypical hyperplasia. Twenty women in a premenopausal phase have been used as a control group. In the patients with AH and EC normo or hypoestradiolaemia have been found. A marked hypoprogesteronaemia has been observed, which is expressed mainly in patients with AH. The low concentrations of progesterone in patients in pre- and postmenopausal phase are important markers for increased morbidity. The study of the progesterone level should become a routine method in the group with high risk of development of endometrial cancer.

Carcinoma↗
PubMed1993

[A trial of the inhibition of adrenal steroidogenesis in girls with hirsutism].

It was tested the influence of 1 tablet Parlodel on the concentration of hypophyseal-ovarian and hypophyseal-adrenal hormones. It was established, that 1 tablet Parlodel reduces the level of testosterone and cortisol of all tested persons at the second hour of the investigation. The influence of 1 tablet Parlodel is stronger with young girls showing higher initial levels of prolactin and testosterone.

Adolescent↗
PubMed1993

[Our clinical experience in treating endometriosis genitalis externa with the preparation Danoval].

By means of the serum level of estradiol and the vaginal smear indexes the antigonadotropic activity of the preparation Danoval (2-3-isoxasol-17-ethinyltestosterone) is indirectly evaluated on 15 infertility patients with laparoscopic proved endometriosis. After 5 month's course of treatment with 400 mg daily the level of estradiol decreased from 1.54 to 0.31 nmol/l, IA from 20.8 to 10.4 and IP from 32 to 17.3. The side effects are slight and descend from the pharmacological properties of the preparation. Two patients became pregnant in three months after the treatment.

Adnexal Diseases↗
PubMed1991

[The effect of electroacupuncture analgesia on the plasma levels of cortisol and aldosterone in orthopedic operations].

The effects of electroacupuncture on plasma cortisol and aldosterone levels in patients undergoing orthopedic operations were studied. Plasma cortisol and aldosterone levels were measured at three stages. Moderate activation of the hypothalamo-pituitary-adrenal system is considered an adjustment response of the organism to the operative trauma, with stable hemodynamic parameters. The total amount of analgetic drugs which the patients received during the postoperative period was three times lower than that in the control group given neuroleptanalgesia; during electroacupuncture analgesia (EAPA) opioids were not applied. It is considered that the use of EAPA lowers the degree of the stress reaction in surgical trauma, providing adequate analgesia and neurovegetative protection of patients during orthopedic operations and in the early postoperative period.

Aldosterone↗
PubMed1991

[Clinical significance of analysis of estrogen and progesterone receptors in human uterine tissues].

The action of steroid hormones in the target cell was found to be associated with the presence of specific receptors in the cytoplasm. Uterine, endometrial, and myometrial tissues obtained at hysterectomy for endometrial carcinomatosis and fibromyomas were used. In fibromyomas, the estrogen and progesterone receptors were found to be higher in the cytosol than in the normal myometrium. In endometrial carcinomatosis, the estrogen receptors were in varying quantities: normal, low, or nil in the cytosol, whereas the progesterone receptors were low or nil.

Binding Sites↗
PubMed1990

[The clinical importance of determining aldosterone in the ascitic fluid].

A method for determination of aldosterone in ascitic fluid is worked out. In 20 patients with advanced liver cirrhosis and ascites the aldosterone level in the blood plasma and in the ascitic fluid was higher than in the healthy controls. The finding of elevated aldosterone level is important for the selection of diuretic since the efficacy of the diuretic treatment in patients with liver cirrhosis depends to a great extent on the level of renin activity and aldosterone.

Aldosterone↗
PubMed1990

[Androstenedione, DHEA sulfate, cortisol, aldosterone and testosterone in bronchial asthma patients].

The basic level and the 24 h rhythm of secretion of cortisol, aldosterone, androstanedion, DHEA-sulfate and testosterone were determined in 26 men with bronchial asthma, 19 up to 50 years of age, in a free from attacks period. 20 of the patients had never been treated with corticosteroids and 6 patients had used corticosteroid drugs. In 26.32% of the patients who had not been treated with corticosteroids the basic cortisole level was either decreased or on the lower normal limit. At the same time in 55% of these patients a different degree increase of the basic DHEA-sulfate level was found and in 30% of the patients the androstanedione basic level was increased. The changes in the 24 h rhythm of androstanedione and DHEA-sulfate secretion were similar to those of cortisol. Normal rhythm of secretion of cortisol, aldosterone and testosterone was established mainly in patients with preserved basic hormonal secretion. In contrast to these, normal rhythm of androstanedione and DHEA-sulfate secretion was found more frequently in patients with increased basic secretion of these hormones.

Adrenal Cortex Hormones↗
PubMed1990

[The differential diagnosis of hairy virilism in polycystic ovaries from adrenal cortical hirsutism].

The hormones on the axis hypophysis-ovary and hypophysis-suprarenal gland were examined in 60 women with polycystic ovaries and hairy virilism, 53 women with hirsutism and 45 healthy women, all of the same age. The results show that in hairy virilism from ovarian origin the luteinizing hormone level (LH) is increased 100% and the follicle stimulating hormone level (FSH) is decreased 200%. The index LH/FSH is increased more than 3 times. The testosterone and androstanedione levels are increased, too. In patients with suprarenal-cortex hirsutism the levels of ACTH, androstanedione, dehydroepiandrosterone-sulfate, testosterone and cortisol are increased. A hirsutism from running with hyperprolactinemia is differentiated. The three hirsutism forms may appear as separate forms or in combination.

Adrenal Cortex Diseases↗
PubMed1988

[The serum testosterone level of patients with bronchial asthma treated with corticosteroids and untreated].

The testosterone basic level was followed up in 427 asthmatic male patients treated and not treated with corticosteroids. In 172 of them (40.68%) basic low blood testosterone was found, in 1/3 of the patients (32.32%) the morning testosterone level was below 200 ng% and in 37 patients (8.67%) it was below 100 ng%. Low blood testosterone was more frequent in the corticosteroid-treated patients than in the patients who had never been treated with corticosteroids (31.63%). Among the untreated patients low blood testosterone was more frequent in the patients with nonatopic (40.82%) than in the patients with atopic (24.67%) and mixed type (27.16%) of bronchial asthma. Low blood testosterone was found mainly in the patients with severe (37.76%) and moderate (40.00%) form of the disease and very rarely in patients with mild form of bronchial asthma (8.51%). The basic testosterone level changes are probably due to the stress, hypoxia and corticosteroid treatment. The possibility of a direct suppressive action of exo- and endoallergens on the testes are discussed.

Adrenal Cortex Hormones↗